公开(公告)号：US11654212B2

公开(公告)日：2023-05-23

申请号：US15558787

申请日：2016-03-17

申请人： UNIVERSITE PIERRE ET MARIE CURIE (PARIS 6) ,  CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE

发明人： Nadine Nassif ,  Francisco Miguel Moreira Martins Fernandes ,  Cedric Boissiere ,  Clement Sanchez ,  Marie-Madeleine Giraud-Guille

IPC分类号： A61L27/24 ,  A61L27/50 ,  A61L27/54 ,  A61L27/52 ,  A61K8/02 ,  A61K8/14 ,  A61K38/39 ,  A61K8/65 ,  A61Q19/08 ,  A61K8/60 ,  C08J3/12

CPC分类号： A61L27/24 ,  A61K8/022 ,  A61K8/025 ,  A61K8/14 ,  A61K8/606 ,  A61K8/65 ,  A61K38/39 ,  A61L27/50 ,  A61L27/52 ,  A61L27/54 ,  A61Q19/08 ,  C08J3/122 ,  A61K2800/412 ,  A61K2800/654 ,  A61K2800/91 ,  A61L2300/232 ,  A61L2300/236 ,  A61L2300/252 ,  A61L2300/402 ,  A61L2300/428 ,  A61L2400/06 ,  A61L2430/06 ,  A61L2430/34 ,  A61L2430/38 ,  C08J2389/00

摘要： Disclosed is the preparation of injectable collagen suspensions, to the method for preparing the suspensions, and to the uses thereof, particularly for forming dense collagen matrices.

公开(公告)号：US11335019B2

公开(公告)日：2022-05-17

申请号：US15556596

申请日：2016-03-15

申请人： UNIVERSITE PIERRE ET MARIE CURIE (PARIS 6) ,  CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE—CNRS ,  INSERM (INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE)

发明人： Ieng Sio-Hoi ,  Benosman Ryad ,  Shi Bertram

IPC分类号： G06T7/593 ,  H04N13/257 ,  H04N13/296 ,  H04N13/239 ,  H04N13/00

摘要： The present invention concerns a method for the 3D reconstruction of a scene comprising the matching (610) of a first event from among the first asynchronous successive events of a first sensor with a second event from among the second asynchronous successive events of a second sensor depending on a minimisation (609) of a cost function (E). The cost function comprises at least one component from: —a luminance component (Ei) that depends at least on a first luminance signal (Iu) convoluted with a convolution core (gσ(t)), the luminance of said pixel depending on a difference between maximums (te−,u,te+,u) of said first signal; and a second luminance signal (Iv) convoluted with said convolution core, the luminance of said pixel depending on a difference between maximums (te−,v,te+,v) of said second signal; —a movement component (EM) depending on at least time values relative to the occurrence of events located at a distance from a pixel of the first sensor and time values relative to the occurrence of events located at a distance from a pixel of the second sensor.

公开(公告)号：US11069445B2

公开(公告)日：2021-07-20

申请号：US15742908

申请日：2016-07-01

申请人： UNIVERSITE PIERRE ET MARIE CURIE (PARIS 6) ,  CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE ,  ASSISTANCE PUBLIQUE—HOPITAUX DE PARIS

发明人： Ferdinand Dhombres ,  Jean-Marie Jouannic ,  Eric Jauniaux ,  Pascal Malengrez ,  Paul Maurice

IPC分类号： G16H50/20 ,  A61B8/08 ,  G16H15/00 ,  A61B5/00

摘要： Disclosed is a method for assistance with the establishment of a diagnosis of a patient, starting from at least one identified sign, and based on a computerized knowledge database including a medical ontology. The medical ontology includes: a list of signs forming a “sign” class; a list of pathological states forming a “pathological state” class; and a first set of logical relationships between the signs and the pathological states, each logical relationship establishing a correlative link between a sign and a pathological state. The method includes: a step of searching for potential pathological states, linked to at least one of the identified signs by the first set of logical relationships; and a step of identifying potential signs in which, for each potential pathological state, all of the signs linked by a correlative link to the potential pathological state are identified by the first set of logical relationships.

公开(公告)号：US10981021B2

公开(公告)日：2021-04-20

申请号：US15067334

申请日：2016-03-11

申请人： Carthera ,  Assistance Publique Hopitaux de Paris ,  Universite Pierre et Marie Curie (Paris 6)

发明人： Alexandre Carpentier ,  Michael Canney ,  Alexandre Vignot

IPC分类号： A61N7/00 ,  A61K41/00 ,  A61K31/555 ,  A61K31/495

摘要： The present invention relates to a method for transiently disrupting a region of the blood-brain barrier (BBB) of a human using ultrasounds in the presence of an ultrasound contrast agent, and uses thereof. The method comprises the application of at least one ultrasound (US) beam with a pressure level higher than 1 MPa and a resonance frequency ranging from 0.5 to 1.5 MHz.

公开(公告)号：US10752668B2

公开(公告)日：2020-08-25

申请号：US15327517

申请日：2015-07-24

申请人： THERAVECTYS ,  INSTITUT CURIE ,  CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE ,  UNIVERSITE PIERRE ET MARIE CURIE ,  INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE (INSERM)

发明人： Sophie Agaugue ,  Lorenzo Tibaldi ,  Klervi Even-Desrumaux ,  Dmitry Trubetskoy ,  Franck Perez ,  Sebastian Amigorena ,  Cécile Bauche

IPC分类号： C07K16/30 ,  G01N33/574 ,  C07K16/28 ,  C07K14/705 ,  C12N5/0783 ,  A61K35/17 ,  C07K16/00 ,  A61K38/00

摘要： The invention relates to the regulated expression of a chimeric antigen receptor (CAR) within a lentiviral vector. The CAR comprises a hook-binding domain that interacts with a hook, preferably encoded by the same lentiviral vector, which prevents proper processing and release of the CAR to the cell membrane. The invention encompasses vectors, methods of making the vectors, and methods of using them, including medicinal uses. The vectors can be used for administration to humans to induce immune responses and to treat cancers and tumors.

公开(公告)号：US20200255912A1

公开(公告)日：2020-08-13

申请号：US16843507

申请日：2020-04-08

申请人： INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE (INSERM) ,  INSTITUT GUSTAVE-ROUSSY ,  Assistance Publique - Hopitaux de Paris ,  Centre Henri Becquerel ,  Universite Paris Descartes ,  Universite Pierre et Marie Curie ,  Universite Paris - SUD

发明人： Franck VIGUIE ,  Olivier BERNARD ,  Michaela FONTENAY ,  Christian BASTARD ,  Francois DELHOMMEAU ,  William VAINCHENKER

IPC分类号： C12Q1/6886 ,  G01N33/574 ,  A61K31/7068

摘要： The present invention concerns an in vitro method for diagnosing a myeloid tumour or a lymphoid tumour in a subject, which comprises the step of analyzing a biological sample from said subject by (i) detecting the presence of a mutation in the Ten Eleven Translocation protein family member 2 gene (TET2) coding for the polypeptide having the sequence SEQ ID NO: 2, and/or (ii) analyzing the expression of the TET2 gene; wherein the detection of such a TET2 mutation, of the absence of expression of TET2 or of the expression of a truncated TET2 is indicative of a subject developing or predisposed to develop a myeloid tumour or a lymphoid tumour.

公开(公告)号：US10736927B2

公开(公告)日：2020-08-11

申请号：US15753475

申请日：2016-08-22

申请人： INSERM (INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE) ,  UNIVERSITE PIERRE ET MARIE CURIE (PARIS 6) ,  INSTITUT NATIONAL DE LA RECHERCHE AGRONOMIQUE (INRA) ,  CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS) ,  ASSISTANCE PUBLIQUE-HOPITAUX DE PARIS (APHP)

发明人： Harry Sokol ,  Mathias Lavie-Richard ,  Marie-Laure Michel ,  Bruno Michel Lamas ,  Philippe Langella

IPC分类号： A61K35/747 ,  C12R1/225 ,  A61P1/00 ,  G01N33/50

摘要： The present invention relates to methods and pharmaceutical compositions for preventing or treating inflammatory bowel diseases.

公开(公告)号：US20200155658A1

公开(公告)日：2020-05-21

申请号：US16681910

申请日：2019-11-13

申请人： INSERM (INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE) ,  UNIVERSITE PARIS DESCARTES ,  UNIVERSITE PIERRE ET MARIE CURIE (PARIS 6) ,  UNIVERSITE PARIS DIDEROT - PARIS 7

发明人： Roberto MALLONE ,  Slobodan CULINA ,  Nimesh GUPTA ,  Sebastien LACROIX-DESMAZES

IPC分类号： A61K39/00 ,  A61P37/06

摘要： The present invention relates to methods and pharmaceutical compositions of inducing immune tolerance by mucosal vaccination with Fc-coupled antigens. In particular, the present invention relates to a method for inducing tolerance to one antigen of interest in a subject in need thereof, comprising the mucosal administration to the subject of a therapeutically effective amount of a recombinant chimeric construct comprising a FcRn targeting moiety and an antigen-containing moiety.

公开(公告)号：US10582977B2

公开(公告)日：2020-03-10

申请号：US15548705

申请日：2016-02-05

申请人： Universite Pierre et Marie Curie (Paris 6) ,  Centre National de la Recherche Scientifique (CNRS) ,  Endocontrol

发明人： Guillaume Morel ,  Lin Dong ,  Florian Richer ,  Nicolas Perrin ,  Clément Vidal ,  Bérengère Bardou

IPC分类号： A61B34/00 ,  A61B34/37 ,  B25J18/00 ,  A61B34/30 ,  A61B90/00

摘要： The invention relates to a device and a method to assist with the operation of an instrument by means of said device, the device and the method using leverage effects in order to calculate the data relative to any point of an instrument axis, instead of using low-accuracy sensors. Other improvements are also described that allow higher-quality usage performance for the operator, which reduces the risk of errors and simplifies the operations.

公开(公告)号：US20200049127A1

公开(公告)日：2020-02-13

申请号：US16486009

申请日：2018-02-14

申请人： Universite Paris Diderot Paris 7 ,  Ecole Superieure De Physique Et De Chimie Industrielles De La Ville De Paris ,  Centre National de la Recherche Scientifique (CNRS) ,  Universite Pierre Et Marie Curie (Paris 6)

发明人： Vincent Cognet ,  Sylvain Courrech Du Pont ,  Benjamin Thiria

IPC分类号： F03D1/06 ,  F01D5/14

摘要： The invention relates to a method for designing a flexible blade or an articulated rigid blade with one or more torsion springs, for a wind turbine or a water turbine, the flexible blade being designed to passively control the pitch angle of the wind turbine or of the water turbine during operation, the method comprising the following steps: a) receiving the known geometric profile; b) determining a change in the optimal pitch angle, 0o opt rigid, as a function of the specific speed λ; c) determining the local behaviour of the flexible blade or of the articulated blade and local ratios relating to the aerodynamic loading and to the centrifugal force being exerted on the blade; d) determining local values of the bending modulus B of the flexible blade/the stiffness of the torsion spring and of the mass density p of the blade; and e) providing information relating to the selection of the material.