公开(公告)号：US09155747B2

公开(公告)日：2015-10-13

申请号：US13964298

申请日：2013-08-12

Applicant: Chiesi farmaceutici S.p.A.

Inventor： Eleonora Ghidini

IPC: A61K31/58 ,  A61M11/00 ,  A61M15/00 ,  A61K45/06 ,  C07J71/00

CPC classification number: C07J71/0068 ,  A61K31/58 ,  A61K45/06 ,  A61M11/00 ,  A61M15/0028

Abstract: Glucocorticosteroids that are derivatives of isoxazolidine are useful as anti-inflammatory and antiallergic compounds of the glucocorticosteroid series.

Abstract translation: 作为异恶唑烷衍生物的糖皮质激素可用作糖皮质激素系列的抗炎和抗过敏化合物。

公开(公告)号：US09845337B2

公开(公告)日：2017-12-19

申请号：US14537184

申请日：2014-11-10

Applicant: CHIESI FARMACEUTICI S.p.A.

Inventor： Eleonora Ghidini ,  Andrea Rizzi

IPC: A61K31/58 ,  C07J71/00 ,  A61K45/06

CPC classification number: C07J71/0068 ,  A61K31/58 ,  A61K45/06

Abstract: Anti-inflammatory and antiallergic compounds of the glucocorticosteroid series, according to formula (I) according to formula (I) defined herein are useful for treating diseases of the respiratory tract characterized by airway obstruction.

公开(公告)号：US09469669B2

公开(公告)日：2016-10-18

申请号：US14844156

申请日：2015-09-03

Applicant: Chiesi Farmaceutici S.p.A.

Inventor： Eleonora Ghidini

IPC: A61K31/58 ,  A61M11/00 ,  A61M15/00 ,  A61K45/06 ,  C07J71/00

CPC classification number: C07J71/0068 ,  A61K31/58 ,  A61K45/06 ,  A61M11/00 ,  A61M15/0028

Abstract: Glucocorticosteroids that are derivatives of isoxazolidine are useful as anti-inflammatory and antiallergic compounds of the glucocorticosteroid series.

公开(公告)号：US10280193B2

公开(公告)日：2019-05-07

申请号：US15807066

申请日：2017-11-08

Applicant: CHIESI FARMACEUTICI S.p.A.

Inventor： Eleonora Ghidini ,  Andrea Rizzi

IPC: A61K31/58 ,  A61K45/06 ,  C07J71/00

Abstract: Anti-inflammatory and antiallergic compounds of the glucocorticosteroid series, according to formula (I) according to formula (I) defined herein are useful for treating diseases of the respiratory tract characterized by airway obstruction.

公开(公告)号：US09133185B2

公开(公告)日：2015-09-15

申请号：US14560140

申请日：2014-12-04

Applicant: CHIESI FARMACEUTICI S.P.A.

Inventor： Gabriele Amari ,  Elisabetta Armani ,  Eleonora Ghidini ,  Charles Baker-Glenn ,  Hervé Van De Poël ,  Ben Whittaker

IPC: C07D453/02 ,  C07D409/14 ,  A61K31/444 ,  A61K31/4439 ,  A61K31/4545 ,  A61K31/4436 ,  A61K31/44 ,  A61M16/14 ,  A61M15/00

CPC classification number: C07D453/02 ,  A61K31/44 ,  A61K31/4436 ,  A61K31/4439 ,  A61K31/444 ,  A61K31/4545 ,  A61M15/0065 ,  A61M16/14 ,  A61M2202/064 ,  C07D401/14 ,  C07D405/14 ,  C07D409/14 ,  C07D413/14 ,  C07D417/14

Abstract: Compounds of formula (I) described herein are both phosphodiesterase 4 (PDE4) enzyme inhibitors and muscarinic M3 receptor antagonists and are useful for the prevention and/or treatment of diseases of the respiratory tract characterized by airway obstruction.

Abstract translation: 本文所述的式（I）化合物既是磷酸二酯酶4（PDE4）酶抑制剂和毒蕈碱M3受体拮抗剂，并且可用于预防和/或治疗以气道阻塞为特征的呼吸道疾病。