公开(公告)号：US10822321B2

公开(公告)日：2020-11-03

申请号：US15970067

申请日：2018-05-03

Applicant: CHIROGATE INTERNATIONAL INC.

Inventor： Shih-Yi Wei ,  Yu-Chih Yeh ,  Min-Kuan Hsu ,  Li-Ta Kao

IPC: C07D313/00 ,  C07D309/12 ,  C07C51/347 ,  C07F7/18 ,  C07D407/12 ,  C07C405/00 ,  C07C59/72 ,  C07C67/10 ,  C07C231/02 ,  C07D407/14 ,  C07C69/608 ,  C07C69/618

Abstract: Novel processes for the preparation of a compound of Formula I-2 substantially free of the 5,6-trans isomer: wherein R2, R3 and R4 are as defined in the specification are provided. Novel intermediates for the preparations of isomer free Prostaglandins and derivatives thereof are also provided.

公开(公告)号：US09828356B2

公开(公告)日：2017-11-28

申请号：US14802026

申请日：2015-07-17

Applicant: CHIROGATE INTERNATIONAL INC.

Inventor： Shih-Yi Wei ,  Yu-Chih Yeh ,  Min-Kuan Hsu ,  Li-Ta Kao

IPC: C07D313/00 ,  C07C69/618 ,  C07C69/608 ,  C07F7/18 ,  C07D309/12 ,  C07C51/347 ,  C07D407/12 ,  C07D405/00 ,  C07C67/10 ,  C07C59/72 ,  C07C405/00 ,  C07C231/02 ,  C07D407/14

CPC classification number: C07D313/00 ,  C07C51/347 ,  C07C59/72 ,  C07C67/10 ,  C07C69/608 ,  C07C69/618 ,  C07C231/02 ,  C07C405/00 ,  C07C405/0016 ,  C07C405/0041 ,  C07C2601/08 ,  C07D309/12 ,  C07D407/12 ,  C07D407/14 ,  C07F7/1804 ,  C07F7/1864

Abstract: Novel processes for the preparation of a compound of Formula I-2 substantially free of the 5,6-trans isomer: wherein R2, R3 and R4 are as defined in the specification are provided. Novel intermediates for the preparations of isomer free Prostaglandins and derivatives thereof are also provided.

公开(公告)号：US20170073323A1

公开(公告)日：2017-03-16

申请号：US15360247

申请日：2016-11-23

Applicant: CHIROGATE INTERNATIONAL INC.

Inventor： Shih-Yi Wei ,  Yu-Chih Yeh ,  Min-Kuan Hsu ,  Li-Ta Kao

IPC: C07D313/00

CPC classification number: C07D313/00 ,  C07C51/347 ,  C07C59/72 ,  C07C67/10 ,  C07C69/608 ,  C07C69/618 ,  C07C231/02 ,  C07C405/00 ,  C07C405/0016 ,  C07C405/0041 ,  C07C2601/08 ,  C07D309/12 ,  C07D407/12 ,  C07D407/14 ,  C07F7/1804

Abstract: Novel processes for the preparation of a compound of Formula I-2 substantially free of the 5,6-trans isomer: wherein R2, R3 and R4 are as defined in the specification are provided. Novel intermediates for the preparations of isomer free Prostaglandins and derivatives thereof are also provided.

Abstract translation: R2，R3和R4如说明书中所定义。 还提供了用于制备不含异构体的前列腺素及其衍生物的新型中间体。

公开(公告)号：US20160016883A1

公开(公告)日：2016-01-21

申请号：US14802072

申请日：2015-07-17

Applicant: CHIROGATE INTERNATIONAL INC.

Inventor： Shih-Yi Wei ,  Yu-Chih Yeh ,  Min-Kuan Hsu ,  Li-Ta Kao

IPC: C07C69/618 ,  C07C59/72 ,  C07D313/00 ,  C07D407/12 ,  C07C69/608

CPC classification number: C07D313/00 ,  C07C51/347 ,  C07C59/72 ,  C07C67/10 ,  C07C69/608 ,  C07C69/618 ,  C07C231/02 ,  C07C405/00 ,  C07C405/0016 ,  C07C405/0041 ,  C07C2601/08 ,  C07D309/12 ,  C07D407/12 ,  C07D407/14 ,  C07F7/1804 ,  C07F7/1864

Abstract: Novel processes for the preparation of a compound of Formula I-2 substantially free of the 5,6-trans isomer: wherein R2, R3 and R4 are as defined in the specification are provided. Novel intermediates for the preparations of isomer free Prostaglandins and derivatives thereof are also provided.

公开(公告)号：US20150336923A1

公开(公告)日：2015-11-26

申请号：US14801999

申请日：2015-07-17

Applicant: CHIROGATE INTERNATIONAL INC.

Inventor： Shih-Yi Wei ,  Yu-Chih Yeh ,  Min-Kuan Hsu ,  Li-Ta Kao

IPC: C07D313/00

CPC classification number: C07D313/00 ,  C07C51/347 ,  C07C59/72 ,  C07C67/10 ,  C07C69/608 ,  C07C69/618 ,  C07C231/02 ,  C07C405/00 ,  C07C405/0016 ,  C07C405/0041 ,  C07C2601/08 ,  C07D309/12 ,  C07D407/12 ,  C07D407/14 ,  C07F7/1804 ,  C07F7/1864

Abstract: Novel processes for the preparation of a compound of Formula I-2 substantially free of the 5,6-trans isomer: wherein R2, R3 and R4 are as defined in the specification are provided. Novel intermediates for the preparations of isomer free Prostaglandins and derivatives thereof are also provided.

公开(公告)号：US09115109B2

公开(公告)日：2015-08-25

申请号：US13967473

申请日：2013-08-15

Applicant: CHIROGATE INTERNATIONAL INC.

Inventor： Shih-Yi Wei ,  Yu-Chih Yeh ,  Min-Kuan Hsu ,  Li-Ta Kao

IPC: C07D313/00 ,  C07C405/00 ,  C07C59/72 ,  C07C67/10 ,  C07C231/02 ,  C07D407/14

CPC classification number: C07D313/00 ,  C07C51/347 ,  C07C59/72 ,  C07C67/10 ,  C07C69/608 ,  C07C69/618 ,  C07C231/02 ,  C07C405/00 ,  C07C405/0016 ,  C07C405/0041 ,  C07C2601/08 ,  C07D309/12 ,  C07D407/12 ,  C07D407/14 ,  C07F7/1804 ,  C07F7/1864

Abstract: Novel processes for the preparation of a compound of Formula I-2 substantially free of the 5,6-trans isomer: wherein R2, R3 and R4 are as defined in the specification are provided. Novel intermediates for the preparations of isomer free Prostaglandins and derivatives thereof are also provided.

Abstract translation: 提供了基本上不含5,6-反式异构体的式I-2化合物的制备方法：其中R2，R3和R4如说明书中所定义。 还提供了用于制备不含异构体的前列腺素及其衍生物的新型中间体。

公开(公告)号：US20180251442A1

公开(公告)日：2018-09-06

申请号：US15970067

申请日：2018-05-03

Applicant: CHIROGATE INTERNATIONAL INC.

Inventor： Shih-Yi Wei ,  Yu-Chih Yeh ,  Min-Kuan Hsu ,  Li-Ta Kao

IPC: C07D313/00 ,  C07C69/618 ,  C07C69/608 ,  C07C405/00 ,  C07D407/12 ,  C07D309/12 ,  C07D407/14 ,  C07C59/72 ,  C07F7/18 ,  C07C51/347

Abstract: Novel processes for the preparation of a compound of Formula I-2 substantially free of the 5,6-trans isomer: wherein R2, R3 and R4 are as defined in the specification are provided. Novel intermediates for the preparations of isomer free Prostaglandins and derivatives thereof are also provided.

公开(公告)号：US09540311B2

公开(公告)日：2017-01-10

申请号：US14801999

申请日：2015-07-17

Applicant: CHIROGATE INTERNATIONAL INC.

Inventor： Shih-Yi Wei ,  Yu-Chih Yeh ,  Min-Kuan Hsu ,  Li-Ta Kao

IPC: C07D313/00 ,  C07C69/618 ,  C07D309/12 ,  C07C51/347 ,  C07F7/18 ,  C07C405/00 ,  C07C59/72 ,  C07C67/10 ,  C07C231/02 ,  C07D407/14 ,  C07D407/12 ,  C07C69/608

CPC classification number: C07D313/00 ,  C07C51/347 ,  C07C59/72 ,  C07C67/10 ,  C07C69/608 ,  C07C69/618 ,  C07C231/02 ,  C07C405/00 ,  C07C405/0016 ,  C07C405/0041 ,  C07C2601/08 ,  C07D309/12 ,  C07D407/12 ,  C07D407/14 ,  C07F7/1804 ,  C07F7/1864

Abstract: Novel processes for the preparation of a compound of Formula I-2 substantially free of the 5,6-trans isomer: wherein R2, R3 and R4 are as defined in the specification are provided. Novel intermediates for the preparations of isomer free Prostaglandins and derivatives thereof are also provided.

Abstract translation: 提供了基本上不含5,6-反式异构体的式I-2化合物的制备方法：其中R 2，R 3和R 4如说明书中所定义。 还提供了用于制备不含异构体的前列腺素及其衍生物的新型中间体。

公开(公告)号：US09464028B2

公开(公告)日：2016-10-11

申请号：US14801966

申请日：2015-07-17

Applicant: CHIROGATE INTERNATIONAL INC.

Inventor： Shih-Yi Wei ,  Yu-Chih Yeh ,  Min-Kuan Hsu ,  Li-Ta Kao

IPC: C07D313/00 ,  C07C69/618 ,  C07D309/12 ,  C07C51/347 ,  C07F7/18 ,  C07C405/00 ,  C07C59/72 ,  C07C67/10 ,  C07C231/02 ,  C07D407/14 ,  C07D407/12 ,  C07C69/608

CPC classification number: C07D313/00 ,  C07C51/347 ,  C07C59/72 ,  C07C67/10 ,  C07C69/608 ,  C07C69/618 ,  C07C231/02 ,  C07C405/00 ,  C07C405/0016 ,  C07C405/0041 ,  C07C2601/08 ,  C07D309/12 ,  C07D407/12 ,  C07D407/14 ,  C07F7/1804 ,  C07F7/1864

Abstract: Novel processes for the preparation of a compound of Formula I-2 substantially free of the 5,6-trans isomer: wherein R2, R3 and R4 are as defined in the specification are provided. Novel intermediates for the preparations of isomer free Prostaglandins and derivatives thereof are also provided.

Abstract translation: 提供了基本上不含5,6-反式异构体的式I-2化合物的制备方法：其中R 2，R 3和R 4如说明书中所定义。 还提供了用于制备不含异构体的前列腺素及其衍生物的新型中间体。

公开(公告)号：US09994543B2

公开(公告)日：2018-06-12

申请号：US14802072

申请日：2015-07-17

Applicant: CHIROGATE INTERNATIONAL INC.

Inventor： Shih-Yi Wei ,  Yu-Chih Yeh ,  Min-Kuan Hsu ,  Li-Ta Kao

IPC: C07D313/00 ,  C07D309/12 ,  C07C51/347 ,  C07F7/18 ,  C07C59/72 ,  C07D407/14 ,  C07D407/12 ,  C07C405/00 ,  C07C69/608 ,  C07C69/618

CPC classification number: C07D313/00 ,  C07C51/347 ,  C07C59/72 ,  C07C67/10 ,  C07C69/608 ,  C07C69/618 ,  C07C231/02 ,  C07C405/00 ,  C07C405/0016 ,  C07C405/0041 ,  C07C2601/08 ,  C07D309/12 ,  C07D407/12 ,  C07D407/14 ,  C07F7/1804 ,  C07F7/1864

Abstract: Novel processes for the preparation of a compound of Formula I-2 substantially free of the 5,6-trans isomer: wherein R2, R3 and R4 are as defined in the specification are provided. Novel intermediates for the preparations of isomer free Prostaglandins and derivatives thereof are also provided.