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公开(公告)号：US09828356B2
公开(公告)日：2017-11-28
申请号：US14802026
申请日：2015-07-17
Applicant: CHIROGATE INTERNATIONAL INC.
Inventor： Shih-Yi Wei , Yu-Chih Yeh , Min-Kuan Hsu , Li-Ta Kao
IPC: C07D313/00 , C07C69/618 , C07C69/608 , C07F7/18 , C07D309/12 , C07C51/347 , C07D407/12 , C07D405/00 , C07C67/10 , C07C59/72 , C07C405/00 , C07C231/02 , C07D407/14
CPC classification number: C07D313/00 , C07C51/347 , C07C59/72 , C07C67/10 , C07C69/608 , C07C69/618 , C07C231/02 , C07C405/00 , C07C405/0016 , C07C405/0041 , C07C2601/08 , C07D309/12 , C07D407/12 , C07D407/14 , C07F7/1804 , C07F7/1864
Abstract: Novel processes for the preparation of a compound of Formula I-2 substantially free of the 5,6-trans isomer: wherein R2, R3 and R4 are as defined in the specification are provided. Novel intermediates for the preparations of isomer free Prostaglandins and derivatives thereof are also provided.
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公开(公告)号：US11339110B2
公开(公告)日：2022-05-24
申请号：US16720711
申请日：2019-12-19
Applicant: CHIROGATE INTERNATIONAL INC.
Inventor： Shih-Yi Wei , Jian-Bang Jheng , Ming-Kun Hsu , Min-Kuan Hsu , Tzyh-Mann Wei
Abstract: There is provided a crystalline Form I of anhydrous Treprostinil and processes for the preparation thereof. The crystalline Form I of anhydrous Treprostnil is a stable crystalline form, which can provide steady physicochemical properties for pharmaceutical formulations, and is advantageous widely and safety used in storage, shipment, and handling for commercially considerations.
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公开(公告)号：US10822321B2
公开(公告)日：2020-11-03
申请号：US15970067
申请日：2018-05-03
Applicant: CHIROGATE INTERNATIONAL INC.
Inventor： Shih-Yi Wei , Yu-Chih Yeh , Min-Kuan Hsu , Li-Ta Kao
IPC: C07D313/00 , C07D309/12 , C07C51/347 , C07F7/18 , C07D407/12 , C07C405/00 , C07C59/72 , C07C67/10 , C07C231/02 , C07D407/14 , C07C69/608 , C07C69/618
Abstract: Novel processes for the preparation of a compound of Formula I-2 substantially free of the 5,6-trans isomer: wherein R2, R3 and R4 are as defined in the specification are provided. Novel intermediates for the preparations of isomer free Prostaglandins and derivatives thereof are also provided.
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公开(公告)号：US10457623B1
公开(公告)日：2019-10-29
申请号：US16034598
申请日：2018-07-13
Applicant: CHIROGATE INTERNATIONAL INC.
Inventor： Shih-Yi Wei , Min-Kuan Hsu
IPC: C07C51/373 , C07F7/08 , C07C31/40 , C07D307/06
Abstract: The present invention relates to a novel process for preparing Lubiprostone and novel intermediates prepared from the process. The process of the present invention does not generate hydrogenated by-products that are difficult to be removed, and thus enables the production of Lubiprostone in an efficient and economical way.
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公开(公告)号：US20180251442A1
公开(公告)日：2018-09-06
申请号：US15970067
申请日：2018-05-03
Applicant: CHIROGATE INTERNATIONAL INC.
Inventor： Shih-Yi Wei , Yu-Chih Yeh , Min-Kuan Hsu , Li-Ta Kao
IPC: C07D313/00 , C07C69/618 , C07C69/608 , C07C405/00 , C07D407/12 , C07D309/12 , C07D407/14 , C07C59/72 , C07F7/18 , C07C51/347
Abstract: Novel processes for the preparation of a compound of Formula I-2 substantially free of the 5,6-trans isomer: wherein R2, R3 and R4 are as defined in the specification are provided. Novel intermediates for the preparations of isomer free Prostaglandins and derivatives thereof are also provided.
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Patent Agency Ranking
6.发明授权Processes and intermediates for the preparations of isomer free prostaglandins 有权用于制备不含异构体的前列腺素的方法和中间体公开(公告)号：US09540311B2
公开(公告)日：2017-01-10
申请号：US14801999
申请日：2015-07-17
Applicant: CHIROGATE INTERNATIONAL INC.
Inventor： Shih-Yi Wei , Yu-Chih Yeh , Min-Kuan Hsu , Li-Ta Kao
IPC: C07D313/00 , C07C69/618 , C07D309/12 , C07C51/347 , C07F7/18 , C07C405/00 , C07C59/72 , C07C67/10 , C07C231/02 , C07D407/14 , C07D407/12 , C07C69/608
CPC classification number: C07D313/00 , C07C51/347 , C07C59/72 , C07C67/10 , C07C69/608 , C07C69/618 , C07C231/02 , C07C405/00 , C07C405/0016 , C07C405/0041 , C07C2601/08 , C07D309/12 , C07D407/12 , C07D407/14 , C07F7/1804 , C07F7/1864
Abstract: Novel processes for the preparation of a compound of Formula I-2 substantially free of the 5,6-trans isomer: wherein R2, R3 and R4 are as defined in the specification are provided. Novel intermediates for the preparations of isomer free Prostaglandins and derivatives thereof are also provided.
Abstract translation: 提供了基本上不含5,6-反式异构体的式I-2化合物的制备方法：其中R 2，R 3和R 4如说明书中所定义。 还提供了用于制备不含异构体的前列腺素及其衍生物的新型中间体。
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7.发明授权Processes and intermediates for the preparations of isomer free prostaglandins 有权用于制备不含异构体的前列腺素的方法和中间体公开(公告)号：US09464028B2
公开(公告)日：2016-10-11
申请号：US14801966
申请日：2015-07-17
Applicant: CHIROGATE INTERNATIONAL INC.
Inventor： Shih-Yi Wei , Yu-Chih Yeh , Min-Kuan Hsu , Li-Ta Kao
IPC: C07D313/00 , C07C69/618 , C07D309/12 , C07C51/347 , C07F7/18 , C07C405/00 , C07C59/72 , C07C67/10 , C07C231/02 , C07D407/14 , C07D407/12 , C07C69/608
CPC classification number: C07D313/00 , C07C51/347 , C07C59/72 , C07C67/10 , C07C69/608 , C07C69/618 , C07C231/02 , C07C405/00 , C07C405/0016 , C07C405/0041 , C07C2601/08 , C07D309/12 , C07D407/12 , C07D407/14 , C07F7/1804 , C07F7/1864
Abstract: Novel processes for the preparation of a compound of Formula I-2 substantially free of the 5,6-trans isomer: wherein R2, R3 and R4 are as defined in the specification are provided. Novel intermediates for the preparations of isomer free Prostaglandins and derivatives thereof are also provided.
Abstract translation: 提供了基本上不含5,6-反式异构体的式I-2化合物的制备方法：其中R 2，R 3和R 4如说明书中所定义。 还提供了用于制备不含异构体的前列腺素及其衍生物的新型中间体。
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公开(公告)号：US09994543B2
公开(公告)日：2018-06-12
申请号：US14802072
申请日：2015-07-17
Applicant: CHIROGATE INTERNATIONAL INC.
Inventor： Shih-Yi Wei , Yu-Chih Yeh , Min-Kuan Hsu , Li-Ta Kao
IPC: C07D313/00 , C07D309/12 , C07C51/347 , C07F7/18 , C07C59/72 , C07D407/14 , C07D407/12 , C07C405/00 , C07C69/608 , C07C69/618
CPC classification number: C07D313/00 , C07C51/347 , C07C59/72 , C07C67/10 , C07C69/608 , C07C69/618 , C07C231/02 , C07C405/00 , C07C405/0016 , C07C405/0041 , C07C2601/08 , C07D309/12 , C07D407/12 , C07D407/14 , C07F7/1804 , C07F7/1864
Abstract: Novel processes for the preparation of a compound of Formula I-2 substantially free of the 5,6-trans isomer: wherein R2, R3 and R4 are as defined in the specification are provided. Novel intermediates for the preparations of isomer free Prostaglandins and derivatives thereof are also provided.
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公开(公告)号：US20180050999A1
公开(公告)日：2018-02-22
申请号：US15796324
申请日：2017-10-27
Applicant: CHIROGATE INTERNATIONAL INC.
Inventor： Shih-Yi Wei , Yu-Chih Yeh , Min-Kuan Hsu , Li-Ta Kao
IPC: C07D313/00 , C07F7/18 , C07D407/14 , C07D407/12 , C07D309/12 , C07C405/00 , C07C69/618 , C07C69/608 , C07C59/72 , C07C51/347
CPC classification number: C07D313/00 , C07C51/347 , C07C59/72 , C07C67/10 , C07C69/608 , C07C69/618 , C07C231/02 , C07C405/00 , C07C405/0016 , C07C405/0041 , C07C2601/08 , C07D309/12 , C07D407/12 , C07D407/14 , C07F7/1804 , C07F7/1864
Abstract: Novel processes for the preparation of a compound of Formula I-2 substantially free of the 5,6-trans isomer: wherein R2, R3 and R4 are as defined in the specification are provided. Novel intermediates for the preparations of isomer free Prostaglandins and derivatives thereof are also provided.
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公开(公告)号：US09890135B1
公开(公告)日：2018-02-13
申请号：US15796324
申请日：2017-10-27
Applicant: CHIROGATE INTERNATIONAL INC.
Inventor： Shih-Yi Wei , Yu-Chih Yeh , Min-Kuan Hsu , Li-Ta Kao
IPC: C07D313/00 , C07D309/12 , C07F7/18 , C07C59/72 , C07D407/14 , C07C51/347 , C07D407/12 , C07C405/00 , C07C69/608 , C07C69/618
CPC classification number: C07D313/00 , C07C51/347 , C07C59/72 , C07C67/10 , C07C69/608 , C07C69/618 , C07C231/02 , C07C405/00 , C07C405/0016 , C07C405/0041 , C07C2601/08 , C07D309/12 , C07D407/12 , C07D407/14 , C07F7/1804 , C07F7/1864
Abstract: Novel processes for the preparation of a compound of Formula I-2 substantially free of the 5,6-trans isomer: wherein R2, R3 and R4 are as defined in the specification are provided. Novel intermediates for the preparations of isomer free Prostaglandins and derivatives thereof are also provided.
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