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公开(公告)号：US20230210991A1
公开(公告)日：2023-07-06
申请号：US17926313
申请日：2021-05-28
发明人： Daisuke Kameoka , Masaya Yasutake , Masakazu Fukuda , Atsushi Watanabe , Tomoyuki Igawa , Chifumi Imai , Akira Hayasaka
CPC分类号： A61K39/39591 , A61K9/08 , A61K9/19 , A61K47/10 , A61K47/22 , A61K47/183 , C07K16/2866 , A61K2039/54 , C07K2317/565
摘要： In one non-limiting embodiment, the present disclosure is an antibody-containing formulation comprising an anti-IL-6 receptor antibody as an active ingredient, and contains histidine-aspartate buffer or histidine-glutamate buffer, Poloxamer 188, and arginine, and has a pH of 5.5 to 6.6. In one non-limiting embodiment, the present disclosure is a method of stabilizing an antibody-containing solution, a method of suppressing antibody association (e.g., dimerization), and a method of suppressing the generation of insoluble particles, wherein L-aspartic acid or L-glutamic acid, and optionally, Poloxamer 188 are added.
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公开(公告)号：US11059881B2
公开(公告)日：2021-07-13
申请号：US16742053
申请日：2020-01-14
IPC分类号： G01N33/68 , G01N11/00 , G01N23/201 , C07K16/00 , C07K16/18 , C07K16/28 , C07K16/30 , C07K16/36
摘要： The inventors discovered that viscosity of a protein solution can be estimated by measuring the apparent particle size or apparent molecular weight by a small angle X-ray scattering (SAXS) method or X-ray solution scattering method, which enables measurement of small amounts of samples, and then correlating those measurement results with viscosity of the protein solution.
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公开(公告)号：US20170362304A1
公开(公告)日：2017-12-21
申请号：US15503441
申请日：2015-08-20
CPC分类号： C07K16/00 , C07K16/18 , C07K16/2866 , C07K16/303 , C07K16/36 , C07K2317/24 , C07K2317/31 , C07K2317/90 , C07K2317/94 , G01N11/00 , G01N23/201
摘要： The inventors discovered that viscosity of a protein solution can be estimated by measuring the apparent particle size or apparent molecular weight by a small angle X-ray scattering (SAXS) method or X-ray solution scattering method, which enables measurement of small amounts of samples, and then correlating those measurement results with viscosity of the protein solution.
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公开(公告)号：US20200283544A1
公开(公告)日：2020-09-10
申请号：US16758128
申请日：2018-10-31
发明人： Kensaku Hosoguchi , Maki Kuwayama , Chifumi Seida , Yosuke Watanabe , Nobuyuki Tanaka , Satoshi Saitoh , Masakazu Fukuda
摘要： As antibody variants and isoforms having reduced FVIII mimetic activity than Emicizumab, the antibody variants having some specific amino acid residues in the variable region cleaved out and missing (Q-CDR-Clipped Variants) and the antibody isoforms having inter-heavy chain disulfide bonds less susceptible to reduction under mild reducing conditions (Protected Disulfide Isoforms) are provided.
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