公开(公告)号：US10041098B2

公开(公告)日：2018-08-07

申请号：US14890423

申请日：2014-05-09

Applicant: CJ CHEILJEDANG CORPORATION

Inventor： Hye Won Kim ,  Sol Kim ,  Jin Sook Chang ,  In Hwa Yoo

IPC: C12P13/12 ,  C12P13/06 ,  C07K14/245

Abstract: The present invention relates to a novel isolated polypeptide having the ability to export O-phosphoserine (OPS) that is a precursor of L-cysteine, a vector comprising the polynucleotide, an OPS-producing microorganism having enhanced activity of the polypeptide, a method of producing OPS using the microorganism, and a method for preparing cysteine or its derivatives, which comprises reacting OPS, produced by the above method, with a sulfide in the presence of O-phosphoserine sulfhydrylase (OPSS) or a microorganism that expresses OPSS.

公开(公告)号：US20190284247A1

公开(公告)日：2019-09-19

申请号：US16423986

申请日：2019-05-28

Applicant: CJ CHEILJEDANG CORPORATION

Inventor： Sol Kim ,  Hye Won Kim ,  Jin Sook Chang ,  In Hwa Yoo

IPC: C07K14/245 ,  C12P13/00 ,  C12P13/06 ,  C12N15/63 ,  C12N9/04 ,  C12N15/52 ,  C12N9/16 ,  C12N9/10 ,  C12P13/12

Abstract: The present invention relates to an RhtB (homoserine/homoserine lactone export transporter) protein variant having an enhanced ability to export O-phosphoserine (OPS) that is a precursor of L-cysteine, a polynucleotide encoding the protein, a vector comprising the polynucleotide, an OPS-producing microorganism comprising the protein variant, a method of producing O-phosphoserine using the microorganism, and a method for preparing cysteine or its derivatives, which comprises reacting O-phosphoserine, produced by the method above, with a sulfide in the presence of O-phosphoserine sulfhydrylase (OPSS) or a microorganism that expresses OPSS.

公开(公告)号：US20190233859A1

公开(公告)日：2019-08-01

申请号：US15758248

申请日：2016-09-09

Applicant: CJ CHEILJEDANG CORPORATION

Inventor： Sol Kim ,  Min Gyeong Kang ,  In Hwa Yoo ,  Jong Hyun Kim ,  Hye Won Kim

IPC: C12P13/12 ,  C07K14/245 ,  C12N9/10 ,  C12N9/16 ,  C12N15/70

CPC classification number: C12P13/12 ,  C07K14/245 ,  C12N9/10 ,  C12N9/16 ,  C12N15/70

Abstract: The present disclosure relates to a novel polypeptide having O-phosphoserine (OPS) exporting activity, a polynucleotide encoding the polypeptide, a microorganism expressing the polypeptide, a method for producing OPS using the microorganism, and a method for producing cysteine or a derivative thereof comprising reacting the O-phosphoserine produced by the same with a sulfide, in the presence of O-phosphoserine sulfhydrylase (OPSS) or a microorganism expressing the same.

公开(公告)号：US20210230610A1

公开(公告)日：2021-07-29

申请号：US16971209

申请日：2019-02-22

Applicant: CJ CHEILJEDANG CORPORATION

Inventor： Sol Kim ,  Jong-cheol Seok ,  Kyusung Lee ,  Jae Woo Jang

IPC: C12N15/81 ,  C12N15/70 ,  C12N15/77 ,  C12N9/10 ,  C12N9/12

Abstract: The present disclosure relates to a microorganism producing a mycosporine-like amino acid and a method for producing a mycosporine-like amino acid using the microorganism.
Since the microorganism of the present disclosure has an increased mycosporine-like amino acid-producing ability, it can be effectively used in producing mycosporine-like amino acids.

公开(公告)号：US10947495B2

公开(公告)日：2021-03-16

申请号：US16474291

申请日：2017-12-28

Applicant: CJ Cheiljedang Corporation

Inventor： Se Hoon Sim ,  Seo-Yun Kim ,  Sol Kim ,  Hye Won Kim ,  Inhwa Yoo

IPC: C12N1/20 ,  C12P13/06 ,  C12P13/12 ,  C12R1/19

Abstract: The present application relates to a microorganism producing O-phosphoserine and a method for producing O-phosphoserine, cysteine or a cysteine derivative using same.

公开(公告)号：US20200283810A1

公开(公告)日：2020-09-10

申请号：US16639200

申请日：2018-08-13

Applicant: CJ CheilJedang Corporation

Inventor： Sol Kim ,  Kyusung Lee ,  Joo Hee Lee ,  Jong-cheol Seok ,  Jae Woo Jang

IPC: C12P13/00 ,  C12N15/77 ,  C12N15/70 ,  C12N15/81

Abstract: The present disclosure relates to a microorganism for producing a mycosporine-like amino acid, and a method for producing a mycosporine-like amino acid using the microorganism.The microorganism of the present disclosure shows an improved ability for producing a mycosporine-like amino acid and thus can be effectively used in the production of a mycosporine-like amino acid.

公开(公告)号：US10696990B2

公开(公告)日：2020-06-30

申请号：US15758248

申请日：2016-09-09

Applicant: CJ CHEILJEDANG CORPORATION

Inventor： Sol Kim ,  Min Gyeong Kang ,  In Hwa Yoo ,  Jong Hyun Kim ,  Hye Won Kim

IPC: C12P13/12 ,  C12N15/00 ,  C12N1/20 ,  C07H21/02 ,  C07K1/00 ,  C07K14/245 ,  C12N9/10 ,  C12N9/16 ,  C12N15/70

Abstract: The present disclosure relates to a novel polypeptide having O-phosphoserine (OPS) exporting activity, a polynucleotide encoding the polypeptide, a microorganism expressing the polypeptide, a method for producing OPS using the microorganism, and a method for producing cysteine or a derivative thereof comprising reacting the O-phosphoserine produced by the same with a sulfide, in the presence of O-phosphoserine sulfhydrylase (OPSS) or a microorganism expressing the same.

公开(公告)号：US10344059B2

公开(公告)日：2019-07-09

申请号：US15679671

申请日：2017-08-17

Applicant: CJ CHEILJEDANG CORPORATION

Inventor： Sol Kim ,  Hye Won Kim ,  Jin Sook Chang ,  In Hwa Yoo

IPC: C12N15/63 ,  C12N15/52 ,  C12N9/16 ,  C12N9/00 ,  C07K14/245 ,  C12P13/12 ,  C12P13/06 ,  C12N9/04 ,  C12N9/10 ,  C12P13/00

Abstract: The present invention relates to an RhtB (homoserine/homoserine lactone export transporter) protein variant having an enhanced ability to export O-phosphoserine (OPS) that is a precursor of L-cysteine, a polynucleotide encoding the protein, a vector comprising the polynucleotide, an OPS-producing microorganism comprising the protein variant, a method of producing O-phosphoserine using the microorganism, and a method for preparing cysteine or its derivatives, which comprises reacting O-phosphoserine, produced by the method above, with a sulfide in the presence of O-phosphoserine sulfhydrylase (OPSS) or a microorganism that expresses OPSS.

公开(公告)号：US10752659B2

公开(公告)日：2020-08-25

申请号：US16423986

申请日：2019-05-28

Applicant: CJ CHEILJEDANG CORPORATION

Inventor： Sol Kim ,  Hye Won Kim ,  Jin Sook Chang ,  In Hwa Yoo

IPC: C12N15/63 ,  C12N15/52 ,  C12N9/16 ,  C12N9/00 ,  C07K14/245 ,  C12P13/12 ,  C12P13/06 ,  C12N9/04 ,  C12N9/10 ,  C12P13/00

Abstract: The present invention relates to an RhtB (homoserine/homoserine lactone export transporter) protein variant having an enhanced ability to export O-phosphoserine (OPS) that is a precursor of L-cysteine, a polynucleotide encoding the protein, a vector comprising the polynucleotide, an OPS-producing microorganism comprising the protein variant, a method of producing O-phosphoserine using the microorganism, and a method for preparing cysteine or its derivatives, which comprises reacting O-phosphoserine, produced by the method above, with a sulfide in the presence of O-phosphoserine sulfhydrylase (OPSS) or a microorganism that expresses OPSS.

公开(公告)号：US10125179B2

公开(公告)日：2018-11-13

申请号：US15679679

申请日：2017-08-17

Applicant: CJ CHEILJEDANG CORPORATION

Inventor： Sol Kim ,  Hye Won Kim ,  Jin Sook Chang ,  In Hwa Yoo

IPC: C12N15/63 ,  C12N15/52 ,  C12N9/16 ,  C12N9/00 ,  C07K14/245 ,  C12P13/12 ,  C12P13/06 ,  C12N9/04 ,  C12N9/10 ,  C12P13/00

Abstract: The present invention relates to an RhtB (homoserine/homoserine lactone export transporter) protein variant having an enhanced ability to export O-phosphoserine (OPS) that is a precursor of L-cysteine, a polynucleotide encoding the protein, a vector comprising the polynucleotide, an OPS-producing microorganism comprising the protein variant, a method of producing O-phosphoserine using the microorganism, and a method for preparing cysteine or its derivatives, which comprises reacting O-phosphoserine, produced by the method above, with a sulfide in the presence of O-phosphoserine sulfhydrylase (OPSS) or a microorganism that expresses OPSS.