公开(公告)号：US10342750B2

公开(公告)日：2019-07-09

申请号：US15106280

申请日：2014-12-19

Applicant: Colgate-Palmolive Company

Inventor： Michael Prencipe ,  Yun Xu ,  Xiao Yi Huang ,  Steven Fisher ,  Betty Won ,  Lyndsay Schaeffer-Korbylo

IPC: A61K8/27 ,  A61K31/32 ,  A61K8/24 ,  A61Q11/00

Abstract: Described herein are oral care compositions comprising a combination of zinc oxide and zinc citrate, and methods of preparing and using the same.

公开(公告)号：US10561590B2

公开(公告)日：2020-02-18

申请号：US16142738

申请日：2018-09-26

Applicant: Colgate-Palmolive Company

Inventor： Gregory Szewczyk ,  Lisa Manus ,  Lyndsay Schaeffer-Korbylo

IPC: A61K8/24 ,  A61K8/21 ,  A61K8/27 ,  A61K8/44 ,  A61K8/46 ,  A61Q11/00 ,  A61K8/25

Abstract: Disclosed herein are dentifrices comprising a zinc amino acid complex together with soluble phosphate salts. Methods of making and using the dentifrices are also provided.

公开(公告)号：US09913784B2

公开(公告)日：2018-03-13

申请号：US15385054

申请日：2016-12-20

Applicant: COLGATE-PALMOLIVE COMPANY

Inventor： Gregory Szewczyk ,  Lisa Manus ,  Lyndsay Schaeffer-Korbylo ,  Andrei Potanin ,  Ravi Subramanyam

IPC: A61K8/21 ,  A61K8/27 ,  A61K8/44 ,  A61K8/81 ,  A61K8/24 ,  A61Q11/00 ,  A61Q11/02

CPC classification number: A61K8/27 ,  A61K8/21 ,  A61K8/24 ,  A61K8/44 ,  A61K8/8176 ,  A61K8/8182 ,  A61K2800/58 ,  A61Q11/00 ,  A61Q11/02

Abstract: Disclosed herein are oral care compositions comprising a zinc amino acid halide complex, and linear polyvinylpyrrolidone and/or sodium tripolyphosphate, which compositions have improved rheological stability. Methods of making and using the compositions are also provided.

公开(公告)号：US09889077B2

公开(公告)日：2018-02-13

申请号：US14527829

申请日：2014-10-30

Applicant: COLGATE-PALMOLIVE COMPANY

Inventor： Lyndsay Schaeffer-Korbylo ,  Andre Michelle Morgan ,  Davide Miksa ,  Laurence Du-Thumm ,  Michael Prencipe ,  Evangelia Arvanitidou ,  Gregory Szewczyk

IPC: A61Q11/00 ,  A61K8/97 ,  A61K8/27 ,  A61K8/34 ,  A01N49/00 ,  A61K8/35 ,  A61K8/33 ,  A61K8/49 ,  A61K8/365 ,  A61K8/19 ,  A61K8/21

CPC classification number: A61K8/34 ,  A01N49/00 ,  A61K8/19 ,  A61K8/21 ,  A61K8/33 ,  A61K8/342 ,  A61K8/347 ,  A61K8/35 ,  A61K8/365 ,  A61K8/4926 ,  A61K8/97 ,  A61K2800/92 ,  A61Q11/00 ,  A01N31/08 ,  A01N31/16 ,  A01N43/40 ,  A01N59/16 ,  A01N65/00 ,  A01N2300/00 ,  A01N65/08

Abstract: Disclosed are oral care compositions and the use of such oral care compositions for treating conditions caused by biofilm formation. Also disclosed are methods for inhibiting biofilm formation and/or degrading biofilm. The oral care composition includes a sesquiterpenoid and an antimicrobial agent, in which the sesquiterpenoid and the antimicrobial agent are present in an amount effective to inhibit and/or degrade a biofilm in the oral cavity.

公开(公告)号：US11471394B2

公开(公告)日：2022-10-18

申请号：US16884958

申请日：2020-05-27

Applicant: Colgate-Palmolive Company ,  The Forsyth Institute

Inventor： Lyndsay Schaeffer-Korbylo ,  Jorge Frias-Lopez

IPC: A61K8/60 ,  A61Q11/00 ,  A61K8/69 ,  C07H5/06 ,  C07H5/02 ,  C07H3/08

Abstract: Described herein are oral care compositions comprising a deoxy sugar antimetabolite and methods of inhibiting microbial biofilm formation and/or degrading a microbial biofilm in a subject.

公开(公告)号：US10563243B2

公开(公告)日：2020-02-18

申请号：US15509901

申请日：2014-09-24

Applicant: Colgate-Palmolive Company

Inventor： Lyndsay Schaeffer-Korbylo ,  Betty Won ,  Venda Porter Maloney ,  Gregory Szewczyk

IPC: C12Q1/18

Abstract: Provided herein is a method for determining the bioavailability of a metal ion in a composition comprising a source of the metal ion, wherein the metal ion has antimicrobial activity, and wherein the method comprises: a) incubating a sample of the composition with bacterial cells, and b) determining the viability of the bacterial cells after incubation. The method is useful for determining the effect of agents on the bioavailability of metal ions in a composition.

公开(公告)号：US20170157013A1

公开(公告)日：2017-06-08

申请号：US14960960

申请日：2015-12-07

Applicant: Colgate-Palmolive Company

Inventor： Lyndsay Schaeffer-Korbylo ,  Lisa Manus

IPC: A61K8/58 ,  A61Q11/00

Abstract: Disclosed herein are methods of promoting the aggregation and/or immune clearance of oral bacteria using oral care compositions comprising metal-amino acid complexes.

公开(公告)号：US09625449B2

公开(公告)日：2017-04-18

申请号：US14580485

申请日：2014-12-23

Applicant: Colgate-Palmolive Company

Inventor： Stanislav Jaracz ,  Harsh M. Trivedi ,  Lyndsay Schaeffer-Korbylo ,  Lynette Zaidel

IPC: G01N21/78 ,  G01N33/84 ,  G01N33/50

CPC classification number: G01N33/5082 ,  G01N21/78 ,  G01N33/84

Abstract: An in vitro method for determining the bioavailability of zinc (II) ions from an oral care composition comprises: providing a sample comprising, the oral care composition; contacting the sample with a biorelevant substrate, separating the biorelevant substrate from the sample, contacting the biorelevant substrate with an indicator under conditions selected such that the indicator is capable of reacting with zinc (II) ions, and determining a light absorbance of the indicator. The indicator is zincon or a salt thereof. The method is useful for estimating the ability of an oral care composition to deliver therapeutically-active zinc (II) ions to the oral cavity. Also provided is the use of zincon and a biorelevant substrate in vitro to determine the bioavailability of zinc (II) ions from an oral care composition comprising, a zinc source.

公开(公告)号：US11278477B2

公开(公告)日：2022-03-22

申请号：US16414847

申请日：2019-05-17

Applicant: Colgate-Palmolive Company

Inventor： Michael Prencipe ,  Yun Xu ,  Xiao Yi Huang ,  Steven Fisher ,  Betty Won ,  Lyndsay Schaeffer-Korbylo

IPC: A61K8/27 ,  A61Q11/00

Abstract: Described herein are oral care compositions comprising a combination of zinc oxide and zinc citrate, and methods of preparing and using the same.

公开(公告)号：US20160178617A1

公开(公告)日：2016-06-23

申请号：US14580485

申请日：2014-12-23

Applicant: Colgate-Palmolive Company

Inventor： Stanislav Jaracz ,  Harsh M. Trivedi ,  Lyndsay Schaeffer-Korbylo ,  Lynette Zaidel

IPC: G01N33/50 ,  G01N21/78

CPC classification number: G01N33/5082 ,  G01N21/78 ,  G01N33/84

Abstract: An in vitro method for determining the bioavailability of zinc (II) ions from an oral care composition comprises: providing a sample comprising, the oral care composition; contacting the sample with a biorelevant substrate, separating the biorelevant substrate from the sample., contacting the biorelevant substrate with an indicator under conditions selected such that the indicator is capable of reacting with zinc (II) ions, and determining a light absorbance of the indicator. The indicator is zincon or a salt thereof. The method is useful for estimating the ability of an oral care composition to deliver therapeutically-active zinc (II) ions to the oral cavity. Also provided is the use of zincon and a biorelevant substrate in vitro to determine the bioavailability of zinc (II) ions from an oral care composition comprising, a zinc source.

Abstract translation: 用于测定来自口腔护理组合物的锌（II）离子的生物利用度的体外方法包括：提供包含口腔护理组合物的样品; 将样品与生物相关底物接触，将生物相关底物与样品分离;在选择的条件下使生物相关底物与指示剂接触，使得指示剂能够与锌（II）离子反应，并确定指示剂的吸光度 。 指示剂是钦康或其盐。 该方法可用于估计口腔护理组合物将治疗活性的锌（II）离子递送至口腔的能力。 还提供了在体外使用锌康和生物相关底物来确定来自包含锌源的口腔护理组合物的锌（II）离子的生物利用度。