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公开(公告)号：US10576033B2
公开(公告)日：2020-03-03
申请号：US15756362
申请日：2017-12-13
发明人： Gregory Szewczyk , Lauren Evans
IPC分类号： A61K8/58 , A61K8/21 , A61K8/24 , A61K8/46 , A61K8/73 , A61K8/81 , A61K8/25 , A61K8/86 , A61K8/44 , A61Q11/00 , A61K8/19 , A61K8/27
摘要： Disclosed herein are dentifrices comprising a zinc-amino acid complex together with a thickening system comprising a non-ionic thickening agent, which have a pH greater than 8.0. Methods of using the dentifrices are also provided.
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公开(公告)号：US10350151B2
公开(公告)日：2019-07-16
申请号：US15539275
申请日：2014-12-26
发明人： Baohua Qiao , Long Pan , Gregory Szewczyk , Ravi Subramanyam , Shiri Nawrocki , Viktor Dubovoy
摘要： A soluble zinc polyphosphate complex made by combining ingredients which include an organic zinc salt and a plurality of long chain polyphosphates having 6 or more phosphate polymer units, the organic zinc salt and long chain polyphosphates being mixed in amounts that provide a phosphorus to zinc mole ratio of 15:1 to about 55:1. Further provided is a method of making this soluble zinc polyphosphate.
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公开(公告)号：US10563243B2
公开(公告)日：2020-02-18
申请号：US15509901
申请日：2014-09-24
IPC分类号： C12Q1/18
摘要： Provided herein is a method for determining the bioavailability of a metal ion in a composition comprising a source of the metal ion, wherein the metal ion has antimicrobial activity, and wherein the method comprises: a) incubating a sample of the composition with bacterial cells, and b) determining the viability of the bacterial cells after incubation. The method is useful for determining the effect of agents on the bioavailability of metal ions in a composition.
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公开(公告)号：US10045927B2
公开(公告)日：2018-08-14
申请号：US15107562
申请日：2014-12-10
IPC分类号： A61Q11/00 , A61K47/38 , A61K9/70 , A61K8/73 , A61K8/34 , A61K8/46 , A61K8/49 , A61K8/02 , A61K8/21
摘要： Surface staining can be minimized or eliminated by providing an oral care composition comprising a first film comprising a pigment; and optionally a second film; wherein the first film has a dissolution rate in aqueous media that is inversely proportional to its thickness, wherein the first film is in the form of a particle.
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公开(公告)号：US20240325440A1
公开(公告)日：2024-10-03
申请号：US18738288
申请日：2024-06-10
发明人： Baohua Qiao , Long Pan , Gregory Szewczyk , Ravi Subramanyam
IPC分类号： A61K33/42 , A61K6/20 , A61K6/74 , A61K8/24 , A61K8/27 , A61K9/00 , A61K33/30 , A61Q11/00 , A61Q15/00 , C01B25/37
CPC分类号： A61K33/42 , A61K6/20 , A61K6/74 , A61K8/24 , A61K8/27 , A61K9/0063 , A61K33/30 , A61Q11/00 , A61Q15/00 , C01B25/37 , A61K2800/262 , A61K2800/58
摘要： A soluble zinc polyphosphate complex made by combining ingredients which include an inorganic zinc salt and a plurality of long chain polyphosphates having 6 or more phosphate polymer units, the relative amount of inorganic zinc salt and long chain polyphosphates providing a phosphorus to zinc mole ratio of at least 6:1. Further provided is a method of making this soluble zinc polyphosphate.
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公开(公告)号：US12005076B2
公开(公告)日：2024-06-11
申请号：US15538330
申请日：2014-12-26
发明人： Baohua Qiao , Long Pan , Gregory Szewczyk , Ravi Subramanyam
IPC分类号： A61K33/42 , A61K6/20 , A61K6/74 , A61K8/24 , A61K8/27 , A61K9/00 , A61K33/30 , A61Q11/00 , A61Q15/00 , C01B25/37
CPC分类号： A61K33/42 , A61K6/20 , A61K6/74 , A61K8/24 , A61K8/27 , A61K9/0063 , A61K33/30 , A61Q11/00 , A61Q15/00 , C01B25/37 , A61K2800/262 , A61K2800/58 , A61K33/42 , A61K2300/00 , A61K33/30 , A61K2300/00
摘要： A soluble zinc polyphosphate complex made by combining ingredients which include an inorganic zinc salt and a plurality of long chain polyphosphates having 6 or more phosphate polymer units, the relative amount of inorganic zinc salt and long chain polyphosphates providing a phosphorus to zinc mole ratio of at least 6:1. Further provided is a method of making this soluble zinc polyphosphate.
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公开(公告)号：US11344486B2
公开(公告)日：2022-05-31
申请号：US16425122
申请日：2019-05-29
发明人： Baohua Qiao , Long Pan , Gregory Szewczyk , Ravi Subramanyam , Shiri Nawrocki , Viktor Dubovoy
摘要： A soluble zinc polyphosphate complex made by combining ingredients which include an organic zinc salt and a plurality of long chain polyphosphates having 6 or more phosphate polymer units, the organic zinc salt and long chain polyphosphates being mixed in amounts that provide a phosphorus to zinc mole ratio of 15:1 to about 55:1. Further provided is a method of making this soluble zinc polyphosphate.
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公开(公告)号：US10561590B2
公开(公告)日：2020-02-18
申请号：US16142738
申请日：2018-09-26
摘要： Disclosed herein are dentifrices comprising a zinc amino acid complex together with soluble phosphate salts. Methods of making and using the dentifrices are also provided.
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公开(公告)号：US10426720B2
公开(公告)日：2019-10-01
申请号：US15107590
申请日：2013-12-23
发明人： Gregory Szewczyk , Nihal Dogu , Suzanne Jogun
IPC分类号： A61K8/25 , A61K8/11 , A61K9/70 , A61Q11/00 , A61K8/73 , A61K9/00 , A61K8/02 , A61K8/34 , A61K8/44
摘要： Described herein are oral compositions comprising a film, wherein the film comprises a dye entrapped in a silica sol-gel.
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公开(公告)号：US09913784B2
公开(公告)日：2018-03-13
申请号：US15385054
申请日：2016-12-20
CPC分类号： A61K8/27 , A61K8/21 , A61K8/24 , A61K8/44 , A61K8/8176 , A61K8/8182 , A61K2800/58 , A61Q11/00 , A61Q11/02
摘要： Disclosed herein are oral care compositions comprising a zinc amino acid halide complex, and linear polyvinylpyrrolidone and/or sodium tripolyphosphate, which compositions have improved rheological stability. Methods of making and using the compositions are also provided.
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