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公开(公告)号：US10563243B2
公开(公告)日：2020-02-18
申请号：US15509901
申请日：2014-09-24
IPC分类号： C12Q1/18
摘要： Provided herein is a method for determining the bioavailability of a metal ion in a composition comprising a source of the metal ion, wherein the metal ion has antimicrobial activity, and wherein the method comprises: a) incubating a sample of the composition with bacterial cells, and b) determining the viability of the bacterial cells after incubation. The method is useful for determining the effect of agents on the bioavailability of metal ions in a composition.
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公开(公告)号：US20160331669A1
公开(公告)日：2016-11-17
申请号：US15106507
申请日：2013-12-20
发明人： Michael Prencipe , Suzanne Jogun , Betty Won
CPC分类号： A61K8/8152 , A61K8/19 , A61K8/20 , A61K8/347 , A61K8/43 , A61K8/4926 , A61K8/58 , A61K2800/28 , A61K2800/43 , A61K2800/48 , A61K2800/524 , A61K2800/5424 , A61K2800/5922 , A61Q11/00 , C09D143/02
摘要： Provided is an oral care composition comprising a phosphate/acrylate co-polymer, a tin salt, and an orally acceptable carrier, and methods of using the same.
摘要翻译： 本发明提供包含磷酸酯/丙烯酸酯共聚物，锡盐和口服可接受的载体的口腔护理组合物及其使用方法。
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公开(公告)号：US11819561B2
公开(公告)日：2023-11-21
申请号：US17359026
申请日：2021-06-25
发明人： Ningwei Li , Hongwei Shen , Saide Tang , Betty Won , Viktor Dubovoy , Long Pan
CPC分类号： A61K8/43 , A61K8/24 , A61Q11/00 , A61K2800/28 , A61K2800/48 , A61K2800/524 , A61K2800/5422 , A61K2800/5426 , A61K2800/5428 , A61K2800/74
摘要： This application provides, among other things, novel aqueous oral care compositions useful for combining and delivering poorly compatible ingredients, in particular, chlorhexidine and polyphosphate salts, by formulating the composition with a surfactant.
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公开(公告)号：US11278477B2
公开(公告)日：2022-03-22
申请号：US16414847
申请日：2019-05-17
发明人： Michael Prencipe , Yun Xu , Xiao Yi Huang , Steven Fisher , Betty Won , Lyndsay Schaeffer-Korbylo
摘要： Described herein are oral care compositions comprising a combination of zinc oxide and zinc citrate, and methods of preparing and using the same.
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公开(公告)号：US11234915B2
公开(公告)日：2022-02-01
申请号：US16815106
申请日：2020-03-11
发明人： Michael Prencipe , Amy Russo , Hansruedi Stettler , Betty Won , Lisa Manus , Michael Stranick , Peng Yan , Chengkang Tan , Vyoma Patel , André Morgan , Andrei Potanin , Xiao Yi Huang
IPC分类号： A61Q11/00 , A61K8/27 , A61K8/21 , A61K8/25 , A61K33/30 , A61K33/16 , A61K6/00 , A61K31/198 , A61K8/44 , A61K8/24 , A61K8/73 , A61K8/04 , A61K8/37 , A61K8/34 , A61K8/365
摘要： This invention relates to oral care compositions comprising arginine or lysine, zinc citrate and zinc oxide, fluoride source, and a silica abrasive which exhibits an acid pH when measured as an aqueous slurry as well as to methods of using and of making these compositions.
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公开(公告)号：US11207254B2
公开(公告)日：2021-12-28
申请号：US16777936
申请日：2020-01-31
发明人： Marcella Mourao , Wilbens Josias , Betty Won , Lisa Manus , Michael A. Stranick , Xiaoyi Huang , Michael Prencipe , Amy Russo , Hansruedi Stettler , Peng Yan , Chengkang Tan , Vyoma Patel , André Michelle Morgan , Andrei Potanin
IPC分类号： A61K8/44 , A61K8/24 , A61K8/27 , A61Q11/00 , A61K8/73 , A61K8/21 , A61K8/04 , A61K8/37 , A61K8/25 , A61K8/34 , A61K8/365
摘要： Described herein are oral care compositions comprising a basic amino acid; a combination of zinc ion sources; and from about 0.75 wt. % to about 2 wt. % of a chelating system; along with methods of making and using same.
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公开(公告)号：US10342750B2
公开(公告)日：2019-07-09
申请号：US15106280
申请日：2014-12-19
发明人： Michael Prencipe , Yun Xu , Xiao Yi Huang , Steven Fisher , Betty Won , Lyndsay Schaeffer-Korbylo
摘要： Described herein are oral care compositions comprising a combination of zinc oxide and zinc citrate, and methods of preparing and using the same.
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公开(公告)号：US20240315941A1
公开(公告)日：2024-09-26
申请号：US18594760
申请日：2024-03-04
发明人： Xiao Yi Huang , Michael Prencipe , Amy Russo , Hansruedi Stettler , Vyoma Patel , Betty Won , Peng Yan , André Morgan
CPC分类号： A61K8/44 , A61K8/21 , A61K8/25 , A61K8/27 , A61K8/345 , A61K8/362 , A61K8/365 , A61Q11/00 , A61K2800/28 , A61K2800/92
摘要： This invention relates to oral care compositions comprising arginine or lysine, zinc citrate and zinc oxide, a fluoride source, and glycerin, as well as to methods of using and of making these compositions.
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公开(公告)号：US10588840B2
公开(公告)日：2020-03-17
申请号：US15749537
申请日：2017-06-23
发明人： Marcella Mourao , Wilbens Josias , Betty Won , Lisa Manus , Michael Stranick , Xiaoyi Huang , Michael Prencipe , Amy Russo , Hansruedi Stettler , Peng Yan , Chengkang Tan , Vyoma Patel , Andre Michelle Morgan , Andrei Potanin
IPC分类号： A61K8/44 , A61K8/24 , A61K8/21 , A61K8/27 , A61Q11/00 , A61K8/73 , A61K8/04 , A61K8/37 , A61K8/25 , A61K8/34 , A61K8/365
摘要： Described herein are oral care compositions comprising a basic amino acid; a combination of zinc ion sources; and from about 0.75 wt. % to about 2 wt. % of a chelating system; along with methods of making and using same.
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公开(公告)号：US09789048B2
公开(公告)日：2017-10-17
申请号：US15106507
申请日：2013-12-20
发明人： Michael Prencipe , Suzanne Jogun , Betty Won
IPC分类号： A61K8/81 , A61Q11/00 , A61K8/19 , C09D143/02 , A61K8/20 , A61K8/34 , A61K8/43 , A61K8/49 , A61K8/58
CPC分类号： A61K8/8152 , A61K8/19 , A61K8/20 , A61K8/347 , A61K8/43 , A61K8/4926 , A61K8/58 , A61K2800/28 , A61K2800/43 , A61K2800/48 , A61K2800/524 , A61K2800/5424 , A61K2800/5922 , A61Q11/00 , C09D143/02
摘要： Provided is an oral care composition comprising a phosphate/acrylate co-polymer, a tin salt, and an orally acceptable carrier, and methods of using the same.
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