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公开(公告)号：US09597434B2
公开(公告)日：2017-03-21
申请号：US14783895
申请日：2014-04-14
申请人： COLORADO STATE UNIVERSITY RESEARCH FOUNDATION , Matthew Kipper , Ketul Popat , Melissa Reynolds , Victoria Leszczak , Raimundo Romero
CPC分类号： A61L31/10 , A61L31/022 , A61L31/16 , A61L2300/114 , A61L2300/236 , A61L2300/252 , A61L2300/414 , A61L2300/45 , A61L2300/606 , A61L2300/61 , A61L2400/12 , A61L2400/18 , A61L2420/02 , A61L2420/08 , B05D7/58 , C25D11/26 , C08L5/10 , C08L5/08
摘要： Surface modified medical devices with nanotubes and polyelectrolyte multilayers, methods of promoting endothelialization, and methods of modifying a medical device surface are disclosed. Nanotubes may be formed on the surface of the medical device and may further be coated with polyelectrolyte multilayers of a polycation and a polyanion. The surface modification is characterized by a nanopattern on the surface of the medical device, with biomimetic properties.
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公开(公告)号：US20160067388A1
公开(公告)日：2016-03-10
申请号：US14783895
申请日：2014-04-14
申请人： Matthew KIPPER , Ketul POPAT , Melissa REYNOLDS , Victoria LESZCZAK , Raimundo ROMERO , COLORADO STATE UNIVERSITY RESEARCH FOUNDATION
CPC分类号： A61L31/10 , A61L31/022 , A61L31/16 , A61L2300/114 , A61L2300/236 , A61L2300/252 , A61L2300/414 , A61L2300/45 , A61L2300/606 , A61L2300/61 , A61L2400/12 , A61L2400/18 , A61L2420/02 , A61L2420/08 , B05D7/58 , C25D11/26 , C08L5/10 , C08L5/08
摘要： Surface modified medical devices with nanotubes and polyelectrolyte multilayers, methods of promoting endothelialization, and methods of modifying a medical device surface are disclosed. Nanotubes may be formed on the surface of the medical device and may further be coated with polyelectrolyte multilayers of a polycation and a polyanion. The surface modification is characterized by a nanopattern on the surface of the medical device, with biomimetic properties.
摘要翻译： 公开了具有纳米管和聚电解质多层的表面改性医疗装置，促进内皮化的方法和修饰医疗器械表面的方法。 可以在医疗装置的表面上形成纳米管，并且可以进一步涂覆聚阳离子和聚阴离子的聚电解质多层。 表面改性的特征在于医疗装置表面上的纳米图案，具有仿生性质。
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公开(公告)号：US11484630B2
公开(公告)日：2022-11-01
申请号：US15954943
申请日：2018-04-17
摘要： In this work, we investigated the blood platelet adhesion and activation of truly superhemophobic surfaces and compared them with that of hemophobic surfaces and hemophilic surfaces. Our analysis indicates that only those superhemophobic surfaces with a robust Cassie-Baxter state display significantly lower platelet adhesion and activation. The understanding gained through this work will lead to the fabrication of improved hemocompatible, superhemophobic medical implants.
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