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1.发明申请公开(公告)号：US20180243358A1
公开(公告)日：2018-08-30
申请号：US15969762
申请日：2018-05-02
发明人： Chang Hyeong LEE , Sang Gyung KIM , Im Hee SHIN , Seung Mo KIM , Joon Seok BYUN , Ki Cheul SOHN , Sae Kwang KU
IPC分类号： A61K36/232 , A61K38/19
CPC分类号： A61K36/232 , A61K38/193 , A61K2300/00
摘要： The present invention relates to a composition for promoting proliferation of bone marrow derived stem cells using an angelicae gigantis radix extract, and more particularly, to a composition which administers a granulocyte colony-stimulating factor into an object, and administers the angelicae gigantis radix extract to the object to promote the proliferation of the bone marrow derived stem cells. The composition of the present invention solves side effects such as splenomegaly which were caused by a method of administering only the G-CSF for proliferation and differentiation of the stem cells, thereby significantly mitigating the side effects through co-administration of the angelicae gigantis radix extract, and further promoting the proliferation and the differentiation of the stem cells.
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2.发明申请COMPOSITION CONTAINING PALMULTANG EXTRACT FOR PROMOTING PROLIFERATION OF STEM CELLS DERIVED FROM BONE MARROW 审中-公开包含PALMULTANG提取物的组合物，用于促进从骨髓衍生的干细胞的增殖公开(公告)号：US20160101156A1
公开(公告)日：2016-04-14
申请号：US14888636
申请日：2014-05-01
发明人： Chang Hyeong LEE , Sang Gyung KIM , Im Hee SHIN , Seung Mo KIM , Joon Seok BYUN , Ki Cheul SOHN , Sae Kwang KU
IPC分类号： A61K38/19 , A61K36/284 , A61K36/484 , A61K36/232 , A61K36/64 , A61K36/65 , A61K36/234 , A61K36/258 , A61K36/07
CPC分类号： A61K38/193 , A61K36/07 , A61K36/076 , A61K36/232 , A61K36/234 , A61K36/258 , A61K36/284 , A61K36/484 , A61K36/64 , A61K36/65 , A61K36/804 , C12N5/0647 , C12N2500/76 , A61K2300/00
摘要： The present invention relates to a composition for promoting the proliferation of stem cells derived from bone marrow using a palmultang extract, and more specifically, to a composition for promoting the proliferation of stern cells derived from bone marrow by administering a granulocyte colony-stimulating factor to a subject and then administering the palmultang extract to the subject. The composition of the present invention remarkably reduces side effects, such as enlargement of the spleen, which are caused by the administration of G-CSF alone for proliferation and differentiation of the stern cells, through administration in combination with the palmultang extract, thereby further promoting the proliferation and differentiation of stem cells.
摘要翻译： 本发明涉及一种使用棕榈ang提取物促进骨髓源性干细胞增殖的组合物，更具体地说，涉及通过对粒细胞集落刺激因子施用粒细胞集落刺激因子促进骨髓细胞增殖的组合物 一个主题，然后将棕榈ang提取物施用于受试者。 本发明的组合物通过与棕榈丹提取物组合施用，显着降低了通过单独施用G-CSF而引起的副作用，例如通过给予尾状细胞的增殖和分化而进一步促进 干细胞的增殖和分化。
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3.发明申请公开(公告)号：US20180185447A1
公开(公告)日：2018-07-05
申请号：US15854613
申请日：2017-12-26
发明人： Chang Hyeong LEE , Sang Gyung KIM , Im Hee SHIN , Seung Mo KIM , Joon Seok BYUN , Ki Cheul SOHN , Sae Kwang KU
IPC分类号： A61K38/19 , A61K36/07 , A61K36/65 , A61K36/484 , A61K36/284 , A61K36/258 , A61K36/234 , A61K36/232 , A61K36/076 , A61K36/804 , C12N5/0789 , A61K36/64
CPC分类号： A61K38/193 , A61K36/07 , A61K36/076 , A61K36/232 , A61K36/234 , A61K36/258 , A61K36/284 , A61K36/484 , A61K36/64 , A61K36/65 , A61K36/804 , C12N5/0647 , C12N2500/76 , A61K2300/00
摘要： The present invention relates to a composition for promoting the proliferation of stem cells derived from bone marrow using a palmultang extract, and specifically, to a composition for promoting the proliferation of stem cells derived from bone marrow by administering a granulocyte colony-stimulating factor to a subject and then administering the palmultang extract to the subject. The composition of the present invention remarkably reduces side effects, such as enlargement of the spleen, which are caused by the administration of G-CSF alone for proliferation and differentiation of the stem cells, through administration in combination with the palmultang extract, thereby further promoting the proliferation and differentiation of stem cells.
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公开(公告)号：US20160184382A1
公开(公告)日：2016-06-30
申请号：US14891284
申请日：2014-05-15
发明人： Joon Seok BYUN , Sae Kwang KU , Ki Cheul SOHN , Seung Mo KIM , Chang Hyeong LEE , Dae Sung HYUN , Jong Dae Kim , Sung Hwan PARK , Min A. KWAK
IPC分类号： A61K36/9068 , A61K31/5377 , A61K31/4412 , A61K36/484 , A61K36/232 , A61K36/756 , A61K36/28 , A61K36/65 , A61K36/88 , A61K36/53 , A61K36/752 , A61K31/138 , A61K36/725
CPC分类号： A61K36/9068 , A61K31/138 , A61K31/44 , A61K31/4412 , A61K31/5377 , A61K36/00 , A61K36/232 , A61K36/28 , A61K36/484 , A61K36/53 , A61K36/65 , A61K36/725 , A61K36/752 , A61K36/756 , A61K36/88 , A61K2300/00
摘要： Provided is a composition for enhancing effects of an anticancer agent using an oriental medicine, jaeumganghwa-tang, bojungikgi-tang, or yukmijihwang-tang. More particularly, provided is a composition for treating a neoplastic disease by administering an anticancer agent into an individual, and administering an oriental medicine into the individual within 30 minutes. The composition remarkably reduces side effects occurring when the anticancer agent is administered alone by co-administration of the oriental medicine, reduces cytotoxicity, and has higher anticancer activity than that when the anticancer agent is administered alone.
摘要翻译： 提供了一种用于增强使用东方药，jaeumganghwa-tang，bojungikgi-tang或yukmijihwang-tang的抗癌剂的效果的组合物。 更具体地，提供了通过向个体施用抗癌剂来治疗肿瘤疾病的组合物，并且在30分钟内向个体施用东方药物。 当通过东方药物的共同施用单独施用抗癌剂时，通过单独施用抗癌剂，降低细胞毒性，抗癌活性更高，抗菌活性显着降低。
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5.发明申请COMPOSITION CONTAINING ANGELICA EXTRACT FOR PROMOTING PROLIFERATION OF STEM CELLS DERIVED FROM BONE MARROW 审中-公开含有ANGELICA萃取物的组合物，用于促进从骨髓衍生的干细胞的增殖公开(公告)号：US20160058810A1
公开(公告)日：2016-03-03
申请号：US14888682
申请日：2014-05-01
发明人： Chang Hyeong LEE , Sang Gyung KIM , Im Hee SHIN , Seung Mo KIM , Joon Seok BYUN , Ki Cheul SOHN , Sae Kwang KU
IPC分类号： A61K36/232 , A61K38/19
CPC分类号： A61K36/232 , A61K38/193 , A61K2300/00
摘要： The present invention relates to a composition for promoting proliferation of bone marrow derived stem cells using an angelicae gigantis radix extract, and more particularly, to a composition which administers a granulocyte colony-stimulating factor into an object, and administers the angelicae gigantis radix extract to the object to promote the proliferation of the bone marrow derived stem cells. The composition of the present invention solves side effects such as splenomegaly which were caused by a method of administering only the G-CSF for proliferation and differentiation of the stem cells, thereby significantly mitigating the side effects through co-administration of the angelicae gigantis radix extract, and further promoting the proliferation and the differentiation of the stem cells.
摘要翻译： 本发明涉及一种使用当归七重提取物促进骨髓来源的干细胞增殖的组合物，更具体地，涉及将粒细胞集落刺激因子施用于对象的组合物，并将当归栀子提取物 促进骨髓源性干细胞增殖的对象。 本发明的组合物解决了通过仅施用G-CSF用于增殖和分化干细胞的方法引起的脾肿大等副作用，从而通过共同给予当归栀子提取物而显着减轻副作用 ，进一步促进干细胞的增殖和分化。
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