公开(公告)号：US20180185447A1

公开(公告)日：2018-07-05

申请号：US15854613

申请日：2017-12-26

申请人： COMPREHENSIVE AND INTEGRATIVE MEDICINE INSTITUTE

发明人： Chang Hyeong LEE ,  Sang Gyung KIM ,  Im Hee SHIN ,  Seung Mo KIM ,  Joon Seok BYUN ,  Ki Cheul SOHN ,  Sae Kwang KU

IPC分类号： A61K38/19 ,  A61K36/07 ,  A61K36/65 ,  A61K36/484 ,  A61K36/284 ,  A61K36/258 ,  A61K36/234 ,  A61K36/232 ,  A61K36/076 ,  A61K36/804 ,  C12N5/0789 ,  A61K36/64

CPC分类号： A61K38/193 ,  A61K36/07 ,  A61K36/076 ,  A61K36/232 ,  A61K36/234 ,  A61K36/258 ,  A61K36/284 ,  A61K36/484 ,  A61K36/64 ,  A61K36/65 ,  A61K36/804 ,  C12N5/0647 ,  C12N2500/76 ,  A61K2300/00

摘要： The present invention relates to a composition for promoting the proliferation of stem cells derived from bone marrow using a palmultang extract, and specifically, to a composition for promoting the proliferation of stem cells derived from bone marrow by administering a granulocyte colony-stimulating factor to a subject and then administering the palmultang extract to the subject. The composition of the present invention remarkably reduces side effects, such as enlargement of the spleen, which are caused by the administration of G-CSF alone for proliferation and differentiation of the stem cells, through administration in combination with the palmultang extract, thereby further promoting the proliferation and differentiation of stem cells.

公开(公告)号：US20180243358A1

公开(公告)日：2018-08-30

申请号：US15969762

申请日：2018-05-02

申请人： COMPREHENSIVE AND INTEGRATIVE MEDICINE INSTITUTE

发明人： Chang Hyeong LEE ,  Sang Gyung KIM ,  Im Hee SHIN ,  Seung Mo KIM ,  Joon Seok BYUN ,  Ki Cheul SOHN ,  Sae Kwang KU

IPC分类号： A61K36/232 ,  A61K38/19

CPC分类号： A61K36/232 ,  A61K38/193 ,  A61K2300/00

摘要： The present invention relates to a composition for promoting proliferation of bone marrow derived stem cells using an angelicae gigantis radix extract, and more particularly, to a composition which administers a granulocyte colony-stimulating factor into an object, and administers the angelicae gigantis radix extract to the object to promote the proliferation of the bone marrow derived stem cells. The composition of the present invention solves side effects such as splenomegaly which were caused by a method of administering only the G-CSF for proliferation and differentiation of the stem cells, thereby significantly mitigating the side effects through co-administration of the angelicae gigantis radix extract, and further promoting the proliferation and the differentiation of the stem cells.

公开(公告)号：US20160101156A1

公开(公告)日：2016-04-14

申请号：US14888636

申请日：2014-05-01

申请人： COMPREHENSIVE AND INTEGRATIVE MEDICINE INSTITUTE

发明人： Chang Hyeong LEE ,  Sang Gyung KIM ,  Im Hee SHIN ,  Seung Mo KIM ,  Joon Seok BYUN ,  Ki Cheul SOHN ,  Sae Kwang KU

IPC分类号： A61K38/19 ,  A61K36/284 ,  A61K36/484 ,  A61K36/232 ,  A61K36/64 ,  A61K36/65 ,  A61K36/234 ,  A61K36/258 ,  A61K36/07

CPC分类号： A61K38/193 ,  A61K36/07 ,  A61K36/076 ,  A61K36/232 ,  A61K36/234 ,  A61K36/258 ,  A61K36/284 ,  A61K36/484 ,  A61K36/64 ,  A61K36/65 ,  A61K36/804 ,  C12N5/0647 ,  C12N2500/76 ,  A61K2300/00

摘要： The present invention relates to a composition for promoting the proliferation of stem cells derived from bone marrow using a palmultang extract, and more specifically, to a composition for promoting the proliferation of stern cells derived from bone marrow by administering a granulocyte colony-stimulating factor to a subject and then administering the palmultang extract to the subject. The composition of the present invention remarkably reduces side effects, such as enlargement of the spleen, which are caused by the administration of G-CSF alone for proliferation and differentiation of the stern cells, through administration in combination with the palmultang extract, thereby further promoting the proliferation and differentiation of stem cells.

摘要翻译： 本发明涉及一种使用棕榈ang提取物促进骨髓源性干细胞增殖的组合物，更具体地说，涉及通过对粒细胞集落刺激因子施用粒细胞集落刺激因子促进骨髓细胞增殖的组合物 一个主题，然后将棕榈ang提取物施用于受试者。 本发明的组合物通过与棕榈丹提取物组合施用，显着降低了通过单独施用G-CSF而引起的副作用，例如通过给予尾状细胞的增殖和分化而进一步促进 干细胞的增殖和分化。

公开(公告)号：US20160058810A1

公开(公告)日：2016-03-03

申请号：US14888682

申请日：2014-05-01

申请人： COMPREHENSIVE AND INTEGRATIVE MEDICINE INSTITUTE

发明人： Chang Hyeong LEE ,  Sang Gyung KIM ,  Im Hee SHIN ,  Seung Mo KIM ,  Joon Seok BYUN ,  Ki Cheul SOHN ,  Sae Kwang KU

IPC分类号： A61K36/232 ,  A61K38/19

CPC分类号： A61K36/232 ,  A61K38/193 ,  A61K2300/00

摘要： The present invention relates to a composition for promoting proliferation of bone marrow derived stem cells using an angelicae gigantis radix extract, and more particularly, to a composition which administers a granulocyte colony-stimulating factor into an object, and administers the angelicae gigantis radix extract to the object to promote the proliferation of the bone marrow derived stem cells. The composition of the present invention solves side effects such as splenomegaly which were caused by a method of administering only the G-CSF for proliferation and differentiation of the stem cells, thereby significantly mitigating the side effects through co-administration of the angelicae gigantis radix extract, and further promoting the proliferation and the differentiation of the stem cells.

摘要翻译： 本发明涉及一种使用当归七重提取物促进骨髓来源的干细胞增殖的组合物，更具体地，涉及将粒细胞集落刺激因子施用于对象的组合物，并将当归栀子提取物 促进骨髓源性干细胞增殖的对象。 本发明的组合物解决了通过仅施用G-CSF用于增殖和分化干细胞的方法引起的脾肿大等副作用，从而通过共同给予当归栀子提取物而显着减轻副作用 ，进一步促进干细胞的增殖和分化。