公开(公告)号：US20170313988A1

公开(公告)日：2017-11-02

申请号：US15520227

申请日：2015-10-19

Applicant: CONSIGLIO NAZIONALE DELLE RICERCHE

Inventor： Ileana ZUCCHI ,  Valeria TRIA ,  Rolland Alvons REINBOLD

IPC: C12N5/074 ,  A61K35/12 ,  C07K14/47

CPC classification number: C12N5/0696 ,  A61K35/12 ,  C07K14/47 ,  C12N2501/998

Abstract: The present invention relates to a new transcript referred to here as INT6-5a, which is an isoform of the human transcript, known in the literature, INT6 full length (INT6-FL) encoded by the gene EIF3E (gene ID 3646, mRNA NM_001568.2), the use thereof in cellular reprogramming methods for the production of induced pluripotent stem cells or somatic stem cells, the cells obtained from such methods, and use thereof.

公开(公告)号：US20200247882A1

公开(公告)日：2020-08-06

申请号：US16482455

申请日：2018-02-05

Applicant: CONSIGLIO NAZIONALE DELLE RICERCHE

Inventor： Ileana ZUCCHI ,  Rolland Alvons REINBOLD

IPC: C07K16/28 ,  C12N15/113 ,  G01N33/574

Abstract: The present invention relates to agents that modulate/regulate the activity of the protein TMEM230 for use in the therapeutic treatment of pathologies in which therapeutic regulation of angiogenesis is advisable or necessary.