公开(公告)号：US20240110913A1

公开(公告)日：2024-04-04

申请号：US18285920

申请日：2022-04-07

Applicant: CORNELL UNIVERSITY

Inventor： Cassandra GUARINO ,  Bettina WAGNER ,  Craig ALTIER

IPC: G01N33/569 ,  G01N33/58

CPC classification number: G01N33/56911 ,  G01N33/585

Abstract: A multiplex assay with an improved sensitivity and specificity for the diagnosis of Brucella canis infection in mammals using two specific antigens (BP26 and Omp31pep) is disclosed. Also disclosed are kits for detecting immune responses to a Brucella canis infection, methods of detection, methods for monitoring progression and methods for treating a Brucella canis infection.

公开(公告)号：US20160263211A1

公开(公告)日：2016-09-15

申请号：US15036257

申请日：2014-11-12

Applicant: CORNELL UNIVERSITY

Inventor： Bettina WAGNER ,  Gillian PERKINS

IPC: A61K39/245 ,  A61K39/42 ,  C12N7/00 ,  C07K14/54 ,  C07K14/005

CPC classification number: A61K39/245 ,  A61K39/12 ,  A61K39/42 ,  A61K2039/505 ,  A61K2039/54 ,  A61K2039/542 ,  A61K2039/545 ,  A61K2039/55 ,  A61K2039/552 ,  A61K2039/55527 ,  A61K2039/575 ,  C07K14/005 ,  C07K14/5406 ,  C07K2319/00 ,  C12N7/00 ,  C12N2710/16034 ,  C12N2710/16734

Abstract: The present invention provides methods for inducing an immune response to a pathogen in neonatal mammals. In particular, the present invention provides methods for inducing an immune response to a pathogen in a neonatal mammal comprising administering to the neonatal mammal a composition comprising a fusion protein between interleukin-4 (IL-4) and a first antigen of the pathogen.

Abstract translation: 本发明提供了在新生儿哺乳动物中诱导对病原体的免疫应答的方法。 特别地，本发明提供了在新生儿哺乳动物中诱导对病原体的免疫应答的方法，包括向新生儿哺乳动物施用包含白细胞介素-4（IL-4）和病原体的第一抗原之间的融合蛋白的组合物。

公开(公告)号：US20240402173A1

公开(公告)日：2024-12-05

申请号：US18699663

申请日：2022-10-14

Applicant: CORNELL UNIVERSITY

Inventor： Bettina WAGNER ,  Elisabeth SIMONIN ,  Susanna BABASYAN

IPC: G01N33/569 ,  G01N33/577 ,  G01N33/68

Abstract: Methods of detecting IgE+ plasmablasts in a mammal are described herein. Also described herein are methods of predicting clinical allergy in a mammal. Additionally, methods of monitoring progression of an allergy along with methods of monitoring efficacy of treatment of an allergy are described.

公开(公告)号：US20170067896A1

公开(公告)日：2017-03-09

申请号：US15261212

申请日：2016-09-09

Applicant: Cornell University

Inventor： Bettina WAGNER

IPC: G01N33/569

CPC classification number: G01N33/569 ,  G01N33/54306 ,  G01N2469/20

Abstract: A serological assay with an improved linear range of detection is disclosed using a fusion protein system, such as an anti-cytokine/cytokine fusion protein (ACYF) system, for evaluating immune responses. Also disclosed are related compositions, fusion proteins, expression vectors, monoclonal antibodies, and kits for practicing the assay method of the present invention.

Abstract translation: 使用融合蛋白系统（例如抗细胞因子/细胞因子融合蛋白（ACYF）系统）公开了具有改善的线性检测范围的血清学检测用于评估免疫应答。 还公开了用于实施本发明的测定方法的相关组合物，融合蛋白，表达载体，单克隆抗体和试剂盒。