公开(公告)号：US20240182922A1

公开(公告)日：2024-06-06

申请号：US18283929

申请日：2022-03-25

Applicant: CORNELL UNIVERSITY ,  UNIVERSITY OF WASHINGTON

Inventor： Shaoyi JIANG ,  Zhefan YUAN ,  Sijin LUOZHONG ,  Wenchao GU ,  Ruoxin LI ,  Bowen LI

IPC: C12N15/86 ,  A61K47/69 ,  A61K48/00

CPC classification number: C12N15/86 ,  A61K47/6901 ,  A61K48/0041 ,  A61K48/0083 ,  C12N2750/14143 ,  C12N2750/14145

Abstract: Compositions and methods for modified viral vectors which mitigate the immunogenicity of viral vectors, enabling multiple administrations of viral-based gene delivery viral vectors are described herein. The viral vectors advantageously possess low immunogenicity and comprise at least one immunosuppressive moiety. Also described herein are methods for introducing genetic material into a cell. Additionally, described herein are methods for preparing a modified viral vector. Lastly, described herein are methods for treating a subject, the method comprising administering to a subject a modified viral vector composition as described above.

公开(公告)号：US20240307309A1

公开(公告)日：2024-09-19

申请号：US18268472

申请日：2021-12-21

Applicant: CORNELL UNIVERSITY

Inventor： Sijin LUOZHONG ,  Zhefan YUAN ,  Shaoyi JIANG ,  Xiaoran HU ,  Sean BAILEY

IPC: A61K9/14 ,  A61K31/7105

CPC classification number: A61K9/145 ,  A61K31/7105

Abstract: A lipid nanoparticle composition comprising: (i) at least one zwitterionic polymer-containing lipid in which a lipid moiety is covalently attached to a zwitterionic polymer; (ii) at least one non-cationic lipid selected from charged and uncharged lipids, but not attached to a polymer; (iii) at least one cationic or ionizable lipid; and (iv) at least one therapeutic substance, and optionally (v) cholesterol or derivative thereof. Also described herein are methods of delivering a therapeutic substance to a subject, the method comprising administering to the subject a lipid nanoparticle composition described above.

公开(公告)号：US20250064741A1

公开(公告)日：2025-02-27

申请号：US18722792

申请日：2022-12-20

Applicant: CORNELL UNIVERSITY

Inventor： Zhefan YUAN ,  Sijin LUOZHONG ,  Shaoyi JIANG

IPC: A61K9/127 ,  A61K9/51 ,  A61K31/663 ,  A61K31/675 ,  A61K31/7105 ,  C07K16/28

Abstract: A method for delivery of a nucleic acid. comprising administering a lipid nanoparticle composition loaded with the nucleic acid to a subject in which monocytes and/or macrophages have been depleted. thereby delivering the nucleic acid into the subject, the method may more particularly be practiced according to the following steps: a) depleting monocytes and/or macrophages in a subject: and b) administering a lipid nanoparticle composition loaded with the nucleic acid to the subject, thereby delivering the nucleic acid into the subject.

公开(公告)号：US20240218398A1

公开(公告)日：2024-07-04

申请号：US18289191

申请日：2022-05-04

Applicant: CORNELL UNIVERSITY

Inventor： Shaoyi JIANG ,  Wenchao GU ,  Sijin LUOZHONG ,  Zhefan YUAN

IPC: C12N15/88 ,  C12N9/22 ,  C12N15/11 ,  C12N15/67

CPC classification number: C12N15/88 ,  C12N9/22 ,  C12N15/11 ,  C12N15/67 ,  C12N2310/20 ,  C12N2510/00

Abstract: Compositions of engineered extracellular vesicles for delivery of cargo to targeted tissues and cells are described herein. Also described herein are methods for making and using the extracellular vesicles described herein. Lastly, described herein are methods for treating a subject, the method comprising administering to a subject an extracellular vesicle as described herein.