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公开(公告)号：US20170037350A1
公开(公告)日：2017-02-09
申请号：US15304313
申请日：2015-04-09
Applicant: CORNING INCORPORATED
Inventor： David Alan Kenney , Nikolaos Pantelis Kladias , Shang-Pin Kwei , Aravind Raghavan Rammohan , Joseph Christopher Wall , Kathy Marie Youngbear
CPC classification number: C12M23/08 , B01F9/0021 , B01F15/00876 , B01F2009/0092 , C12M27/20
Abstract: A 5-liter bioreactor vessel enables a substantial increase in the volume of biological media that can be cultivated in the vessel compared to conventional designs. Moreover, when agitated at 1.5× the shaking frequency of a conventional 3-liter bioreactor (i.e., 90 rpm versus 60 rpm), the 5-liter vessel achieves a 19% increase in cell aeration without exceeding the maximum shear stress limit for cell viability. The 5-liter vessel optionally includes a plurality of internal baffles configured to disrupt the liquid vortex and reduce the maximum shear stress transferred to biomedia contained within the vessel.
Abstract translation: 与常规设计相比，5升生物反应器容器能够显着增加在容器中培养的生物培养基的体积。 此外，当以常规3升生物反应器（即90rpm至60rpm）的振荡频率为1.5倍搅拌时，5升容器在不超过细胞活力的最大剪切应力极限的情况下实现细胞曝气增加19％ 。 5升容器可选地包括多个内部挡板，其构造成破坏液体涡流并减少转移到容器内所含生物媒体的最大剪切应力。
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公开(公告)号：US20180221863A1
公开(公告)日：2018-08-09
申请号：US15504553
申请日：2015-08-20
Applicant: CORNING INCORPORATED
Inventor： John Claude Cadotte, JR. , Michael Patrick Keenan , David Alan Kenney , Aravind Raghavan Rammohan , Joseph Christopher Wall , Jin Wang
IPC: B01L3/02
CPC classification number: B01L3/0275 , B01L2200/12 , B01L2300/0832 , B01L2300/0848 , B01L2300/12 , B29C45/27 , B29K2023/12 , B29K2995/0097 , B29L2023/22
Abstract: A pipette tip includes a proximal end having an aperture and a proximal body region having a first internal cavity that receives a pipette member, and a distal end having an aperture and a distal body region having a second internal cavity that in operation receives and discharges a liquid aspirated by the pipette member, where the ratio of the proximal half weight of the pipette tip to the distal half weight of the pipette tip normalized to the total weight of the pipette tip has a value, defined as a thinning constant, wherein the pipette tip has a wall thickness of less than 0.022 inches over the distal region.
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公开(公告)号：US11578296B2
公开(公告)日：2023-02-14
申请号：US16463910
申请日：2017-11-29
Applicant: CORNING INCORPORATED
Inventor： James M. Philippe , Aravind Raghavan Rammohan , Paul Kevin Seeto , Neng Wang
Abstract: A closure assembly is provided. The closure assembly includes a cap portion, a tubular neck extending from a top surface of the cap portion, and at least one reinforcing member extending between the top surface of the cap portion and an exterior surface of the tubular neck, wherein the cap portion, the tubular neck and the at least one reinforcing member are a unitary integral piece. The closure assembly design provides stability to the tubular neck and the cap portion when a force is applied to either one or both of the tubular neck and the cap portion.
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公开(公告)号：US11136542B2
公开(公告)日：2021-10-05
申请号：US16077573
申请日：2017-02-13
Applicant: Corning Incorporated
Inventor： Sumitava De , Yulong Hong , Nikolaos Pantelis Kladias , Shawn Michael O'Malley , Aravind Raghavan Rammohan , Po Ki Yuen
Abstract: A perfusion bioreactor and a method for using the perfusion bioreactor for performing a continuous cell culture are disclosed. The perfusion bioreactor includes an outer vessel having a housing with a gas permeable membrane, an opening and a cavity; an inner vessel within the cavity; and a lid to cover the opening. A porous membrane within the cavity divides the cavity into inner and outer compartments. A fresh media port extends through the outer vessel or the at least one lid to receive a fresh media tube that has an end located in the inner compartment. A spent media port extends through the outer vessel or the at least one lid to receive a spent media tube that has an end located in the outer compartment. A mixer is within the inner compartment, and the porous membrane is attached to an opening within the inner vessel.
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