公开(公告)号：US11524920B2

公开(公告)日：2022-12-13

申请号：US17112192

申请日：2020-12-04

申请人： Corning Incorporated

发明人： Sumitava De ,  Robert Clark Moore ,  Douglas Gregg Neilson ,  Pushkar Tandon

IPC分类号： C03C25/12 ,  C03C25/105 ,  C03C25/18

摘要： An optical fiber coating apparatus that provides increased gyre stability and reduced gyre strength, thereby providing a more reliable coating application process during fiber drawing includes a cone-only coating die having a conical entrance portion with a tapered wall angled at a half angle α, wherein 2°≤α≤25°, and a cone height L1 less than 2.2 mm, and a cylindrical portion having an inner diameter of d2, wherein 0.1 mm≤d2≤0.5 mm and a cylindrical height of L2, wherein 0.05 mm≤L2≤1.25 mm; a guide die having an optical fiber exit, the guide die disposed adjacent the cone-only coating die such that a wetted length (L5) between the optical fiber exit of the guide die and the entrance of the cone-only coating die is from 1 mm to 5 mm; and a holder for holding the cone-only coating die and the guide die in a fixed relationship defining a coating chamber between the guide die and the cone-only coating die, the coating chamber having an inner radius L6 from the optical fiber axis to an inner wall of the holder that is from 3 mm to 10 mm.

公开(公告)号：US20230348834A1

公开(公告)日：2023-11-02

申请号：US17779044

申请日：2020-10-30

申请人： CORNING INCORPORATED

发明人： Sumitava De ,  Abhijit Rao ,  Ryann Loren Russell ,  Yujian Sun

IPC分类号： C12M1/12 ,  C12M1/08

CPC分类号： C12M25/18 ,  C12M27/24

摘要： A packed-bed bioreactor is provided that includes: a vessel having an interior cavity defined by an outer wall; and a center column disposed within the interior cavity. The center column includes a columnar sidewall defining an inner region within the center column, the columnar sidewall separating the inner region from an outer region within the interior cavity. The bioreactor further includes a cell culture substrate disposed in the outer region of the cavity, the cell culture substrate surrounding the center column; at least one port extending through the vessel for at least one supply and removal of media to or from the interior cavity; and a fountain head element disposed above the center column.

公开(公告)号：US11440839B2

公开(公告)日：2022-09-13

申请号：US17112166

申请日：2020-12-04

申请人： Corning Incorporated

发明人： Sumitava De ,  Robert Clark Moore ,  Douglas Gregg Neilson ,  Pushkar Tandon

IPC分类号： C03C25/18 ,  C03C25/105

摘要： An optical fiber coating apparatus that provides increased gyre stability and reduced gyre strength, thereby providing a more reliable coating application process during fiber drawing includes a cone-only coating die having a conical entrance portion with a tapered wall angled at a half angle α, wherein 2°≤α≤25°, and a cone height L1 less than 2.2 mm, and a cylindrical portion having an inner diameter of d2, wherein 0.1 mm≤d2≤0.5 mm and a cylindrical height of L2, wherein 0.05 mm≤L2≤1.25 mm; a guide die having an optical fiber exit, the guide die disposed adjacent the cone-only coating die such that a wetted length (L5) between the optical fiber exit of the guide die and the entrance of the cone-only coating die is from 1 mm to 5 mm; and a holder for holding the cone-only coating die and the guide die in a fixed relationship defining a coating chamber between the guide die and the cone-only coating die, the coating chamber having an inner radius L6 from the optical fiber axis to an inner wall of the holder that is from 3 mm to 10 mm.

公开(公告)号：US11136542B2

公开(公告)日：2021-10-05

申请号：US16077573

申请日：2017-02-13

申请人： Corning Incorporated

发明人： Sumitava De ,  Yulong Hong ,  Nikolaos Pantelis Kladias ,  Shawn Michael O'Malley ,  Aravind Raghavan Rammohan ,  Po Ki Yuen

IPC分类号： C12N1/00 ,  C12M1/04 ,  C12M1/00 ,  C12M1/06 ,  C12M1/12

摘要： A perfusion bioreactor and a method for using the perfusion bioreactor for performing a continuous cell culture are disclosed. The perfusion bioreactor includes an outer vessel having a housing with a gas permeable membrane, an opening and a cavity; an inner vessel within the cavity; and a lid to cover the opening. A porous membrane within the cavity divides the cavity into inner and outer compartments. A fresh media port extends through the outer vessel or the at least one lid to receive a fresh media tube that has an end located in the inner compartment. A spent media port extends through the outer vessel or the at least one lid to receive a spent media tube that has an end located in the outer compartment. A mixer is within the inner compartment, and the porous membrane is attached to an opening within the inner vessel.

公开(公告)号：US10882782B2

公开(公告)日：2021-01-05

申请号：US15868029

申请日：2018-01-11

申请人： Corning Incorporated

发明人： Sumitava De ,  Robert Clark Moore ,  Douglas Gregg Neilson ,  Pushkar Tandon

IPC分类号： C03B25/12 ,  C03C25/105 ,  C03C25/18

摘要： An optical fiber coating apparatus that provides increased gyre stability and reduced gyre strength, thereby providing a more reliable coating application process during fiber drawing includes a cone-only coating die having a conical entrance portion with a tapered wall angled at a half angle α, wherein 2°≤α≤25°, and a cone height L1 less than 2.2 mm, and a cylindrical portion having an inner diameter of d2, wherein 0.1 mm≤d2≤0.5 mm and a cylindrical height of L2, wherein 0.05 mm≤L2≤1.25 mm; a guide die having an optical fiber exit, the guide die disposed adjacent the cone-only coating die such that a wetted length (L5) between the optical fiber exit of the guide die and the entrance of the cone-only coating die is from 1 mm to 5 mm; and a holder for holding the cone-only coating die and the guide die in a fixed relationship defining a coating chamber between the guide die and the cone-only coating die, the coating chamber having an inner radius L6 from the optical fiber axis to an inner wall of the holder that is from 3 mm to 10 mm.

公开(公告)号：US20230124478A1

公开(公告)日：2023-04-20

申请号：US17915665

申请日：2021-03-26

申请人： CORNING INCORPORATED

发明人： Sumitava De ,  Cameron Wayne Tanner

IPC分类号： H01M4/36 ,  H01M4/58 ,  H01M10/0563 ,  H01M4/04

摘要： A sintered electrode for a battery, the sintered electrode having a first surface positioned to face a current collector and a second surface positioned to face an electrolyte layer, such that the sintered electrode includes: a first phase and a second phase, such that: the first phase has a lithium compound, and the second phase has at least one of a porous structure or solid-state Li-ion conductors, and such that: a thickness of the sintered electrode between the first surface and the second surface ranges between 10 μm and 200 μm.

公开(公告)号：US20210087108A1

公开(公告)日：2021-03-25

申请号：US17112192

申请日：2020-12-04

申请人： Corning Incorporated

发明人： Sumitava De ,  Robert Clark Moore ,  Douglas Gregg Neilson ,  Pushkar Tandon

IPC分类号： C03C25/105 ,  C03C25/18

摘要： An optical fiber coating apparatus that provides increased gyre stability and reduced gyre strength, thereby providing a more reliable coating application process during fiber drawing includes a cone-only coating die having a conical entrance portion with a tapered wall angled at a half angle α, wherein 2°≤α≤25°, and a cone height L1 less than 2.2 mm, and a cylindrical portion having an inner diameter of d2, wherein 0.1 mm≤d2≤0.5 mm and a cylindrical height of L2, wherein 0.05 mm≤L2≤1.25 mm; a guide die having an optical fiber exit, the guide die disposed adjacent the cone-only coating die such that a wetted length (L5) between the optical fiber exit of the guide die and the entrance of the cone-only coating die is from 1 mm to 5 mm; and a holder for holding the cone-only coating die and the guide die in a fixed relationship defining a coating chamber between the guide die and the cone-only coating die, the coating chamber having an inner radius L6 from the optical fiber axis to an inner wall of the holder that is from 3 mm to 10 mm.

公开(公告)号：US20210087107A1

公开(公告)日：2021-03-25

申请号：US17112166

申请日：2020-12-04

申请人： Corning Incorporated

发明人： Sumitava De ,  Robert Clark Moore ,  Douglas Gregg Neilson ,  Pushkar Tandon

IPC分类号： C03C25/105 ,  C03C25/18

摘要： An optical fiber coating apparatus that provides increased gyre stability and reduced gyre strength, thereby providing a more reliable coating application process during fiber drawing includes a cone-only coating die having a conical entrance portion with a tapered wall angled at a half angle α, wherein 2°≤α≤25°, and a cone height L1 less than 2.2 mm, and a cylindrical portion having an inner diameter of d2, wherein 0.1 mm≤d2≤0.5 mm and a cylindrical height of L2, wherein 0.05 mm≤L2≤1.25 mm; a guide die having an optical fiber exit, the guide die disposed adjacent the cone-only coating die such that a wetted length (L5) between the optical fiber exit of the guide die and the entrance of the cone-only coating die is from 1 mm to 5 mm; and a holder for holding the cone-only coating die and the guide die in a fixed relationship defining a coating chamber between the guide die and the cone-only coating die, the coating chamber having an inner radius L6 from the optical fiber axis to an inner wall of the holder that is from 3 mm to 10 mm.

公开(公告)号：US20190048305A1

公开(公告)日：2019-02-14

申请号：US16077573

申请日：2017-02-13

申请人： Corning Incorporated

发明人： Sumitava De ,  Yulong Hong ,  Nikolaos Pantelis Kladias ,  Shawn Michael O'Malley ,  Aravind Raghaven Rammohan ,  Po Ki Yuen

IPC分类号： C12M1/00 ,  C12M1/04 ,  C12M1/06 ,  C12M1/12

摘要： The present disclosure generally relates to the bioprocess field and, in particular, to a perfusion bioreactor and a method for using the perfusion bioreactor for performing a continuous cell culture.

公开(公告)号：US20180208504A1

公开(公告)日：2018-07-26

申请号：US15868029

申请日：2018-01-11

申请人： Corning Incorporated

发明人： Sumitava De ,  Robert Clark Moore ,  Douglas Gregg Neilson ,  Pushkar Tandon

IPC分类号： C03C25/105 ,  C03C25/18

CPC分类号： C03C25/105 ,  C03C25/18

摘要： An optical fiber coating apparatus that provides increased gyre stability and reduced gyre strength, thereby providing a more reliable coating application process during fiber drawing includes a cone-only coating die having a conical entrance portion with a tapered wall angled at a half angle α, wherein 2°≤α≤25°, and a cone height L1 less than 2.2 mm, and a cylindrical portion having an inner diameter of d2, wherein 0.1 mm≤d2≤0.5 mm and a cylindrical height of L2, wherein 0.05 mm≤L2≤1.25 mm; a guide die having an optical fiber exit, the guide die disposed adjacent the cone-only coating die such that a wetted length (L5) between the optical fiber exit of the guide die and the entrance of the cone-only coating die is from 1 mm to 5 mm; and a holder for holding the cone-only coating die and the guide die in a fixed relationship defining a coating chamber between the guide die and the cone-only coating die, the coating chamber having an inner radius L6 from the optical fiber axis to an inner wall of the holder that is from 3 mm to 10 mm.