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    CELL CULTURE VESSELS AND MONITORING SYSTEMS FOR NON-INVASIVE CELL CULTURE MONITORING
    1.
    发明申请
    CELL CULTURE VESSELS AND MONITORING SYSTEMS FOR NON-INVASIVE CELL CULTURE MONITORING 有权

    公开(公告)号：US20220389367A1

    公开(公告)日：2022-12-08

    申请号：US17776044

    申请日：2020-10-26

    Applicant: CORNING INCORPORATED

    Inventor： Gregory Roger Martin ,  Mark Christian Sanson ,  Nikhil Baburam Vasudeo ,  Joseph Christopher Wall

    IPC: C12M1/34 ,  C12M1/12 ,  C12M1/24

    Abstract: A cell culture vessel, cell culture monitoring system, and Raman spectroscopy system for non-invasive measuring of a cell culture are provided. The vessel includes a cell culture chamber that operates as a closed system, a wall defining a boundary of the cell culture chamber and separating the interior space of the cell culture chamber from an exterior of the cell culture chamber, and a window disposed in the wall and separating the interior space of the cell culture chamber from an exterior of the cell culture chamber. The cell culture chamber includes an interior space for housing at least one of the cell culture and a cell culture media. The window includes a polymer and allows monitoring of the cell culture via a monitoring module disposed on the exterior without the monitoring module coming into physical contact with the cell culture or the cell culture media.

    CELL CULTIVATING FLASK
    4.
    发明申请
    CELL CULTIVATING FLASK 审中-公开
    细胞培养FLASK

    公开(公告)号：US20150315536A1

    公开(公告)日：2015-11-05

    申请号：US14647558

    申请日：2013-11-27

    Applicant: David Alan KENNEY ,  Todd Michael TON ,  Joseph Christopher WALL ,  CORNING INCORPORATED

    Inventor： David Alan Kenney ,  Todd Michael Upton ,  Joseph Christopher Wall

    IPC: C12M1/24 ,  C12M1/12

    CPC classification number: C12M23/08 ,  C12M25/06

    Abstract: A flask for the culturing of cells is disclosed. The cell culture chamber is defined by top and bottom walls connected by side and end walls, one end wall shaped such that media can drain to a bottommost spot thereby allowing for the complete removal of media via a vertically oriented pipette inserted into the interior of the flask body through an open neck.

    Abstract translation: 公开了一种培养细胞的烧瓶。 细胞培养室由通过侧壁和端壁连接的顶壁和底壁限定，一个端壁成形为使得介质可以排放到最下面的点，从而允许通过插入到内部的内部的垂直取向的移液管完全去除介质 瓶身通过开放的颈部。

    REMOTE MONITORING SYSTEM FOR CELL CULTURE
    5.
    发明申请
    REMOTE MONITORING SYSTEM FOR CELL CULTURE 有权

    公开(公告)号：US20210024872A1

    公开(公告)日：2021-01-28

    申请号：US16969016

    申请日：2019-02-08

    Applicant: CORNING INCORPORATED

    Inventor： Gregory Roger Martin ,  Joseph Christopher Wall ,  Alan Craig Wright

    IPC: C12M1/34 ,  C12M1/12 ,  C12M1/24

    Abstract: A remote monitoring system configured to non-invasively measure a cell culture is provided. The system includes a plurality of cell culture layers comprising a cell culture chamber configured to operate as a closed-system, the at least one cell culture chamber having at least one surface to which cells adhere. The system further includes at least one monitoring layer comprising an outer wall surrounding a monitoring layer cell culture chamber configured to operate as a closed-system and having at least one surface to which cells adhere, the at least one monitoring layer comprising at least one indentation in the outer wall. The system also includes at least one monitoring module disposed in at least one of the at least one indentation and comprising at least one of a confluence monitor and an analyte monitor.

    Cell culture system with manifold
    6.
    发明授权
    Cell culture system with manifold 有权

    公开(公告)号：US10316281B2

    公开(公告)日：2019-06-11

    申请号：US15691102

    申请日：2017-08-30

    Applicant: CORNING INCORPORATED

    Inventor： David Alan Kenney ,  Gregory Roger Martin ,  Allison Jean Tanner ,  Joseph Christopher Wall

    IPC: C12M1/00 ,  C12M3/00 ,  C12M1/24

    Abstract: A cell culture apparatus includes cell culture units having cell culture chambers, each with at least one manifold. The manifold connects the cell culture unit to a fluid flow channel. The manifold has a dam which allows liquid to pool in the manifold and allows for the creation of an airspace in the manifold, which reduces hydrostatic pressure inside the apparatus and enables the stacking of multiple cell culture units. Embodiments include cascading manifolds, manifolds having reservoirs, and manifolds having valves.

    VESSEL FOR GROWTH OF BIOLOGICAL ENTITIES
    8.
    发明申请
    VESSEL FOR GROWTH OF BIOLOGICAL ENTITIES 审中-公开
    生物制品生长用船

    公开(公告)号：US20170037350A1

    公开(公告)日：2017-02-09

    申请号：US15304313

    申请日：2015-04-09

    Applicant: CORNING INCORPORATED

    Inventor： David Alan Kenney ,  Nikolaos Pantelis Kladias ,  Shang-Pin Kwei ,  Aravind Raghavan Rammohan ,  Joseph Christopher Wall ,  Kathy Marie Youngbear

    IPC: C12M1/24 ,  C12M1/00

    CPC classification number: C12M23/08 ,  B01F9/0021 ,  B01F15/00876 ,  B01F2009/0092 ,  C12M27/20

    Abstract: A 5-liter bioreactor vessel enables a substantial increase in the volume of biological media that can be cultivated in the vessel compared to conventional designs. Moreover, when agitated at 1.5× the shaking frequency of a conventional 3-liter bioreactor (i.e., 90 rpm versus 60 rpm), the 5-liter vessel achieves a 19% increase in cell aeration without exceeding the maximum shear stress limit for cell viability. The 5-liter vessel optionally includes a plurality of internal baffles configured to disrupt the liquid vortex and reduce the maximum shear stress transferred to biomedia contained within the vessel.

    Abstract translation: 与常规设计相比，5升生物反应器容器能够显着增加在容器中培养的生物培养基的体积。 此外，当以常规3升生物反应器（即90rpm至60rpm）的振荡频率为1.5倍搅拌时，5升容器在不超过细胞活力的最大剪切应力极限的情况下实现细胞曝气增加19％ 。 5升容器可选地包括多个内部挡板，其构造成破坏液体涡流并减少转移到容器内所含生物媒体的最大剪切应力。

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