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公开(公告)号：US20180051242A1
公开(公告)日：2018-02-22
申请号：US15691102
申请日：2017-08-30
Applicant: CORNING INCORPORATED
CPC classification number: C12M23/08 , C12M23/34 , C12M23/40 , C12M23/44 , Y10T29/49826
Abstract: A cell culture apparatus includes cell culture units having cell culture chambers, each with at least one manifold. The manifold connects the cell culture unit to a fluid flow channel. The manifold has a dam which allows liquid to pool in the manifold and allows for the creation of an airspace in the manifold, which reduces hydrostatic pressure inside the apparatus and enables the stacking of multiple cell culture units. Embodiments include cascading manifolds, manifolds having reservoirs, and manifolds having valves.
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公开(公告)号：US20180221863A1
公开(公告)日：2018-08-09
申请号：US15504553
申请日：2015-08-20
Applicant: CORNING INCORPORATED
Inventor： John Claude Cadotte, JR. , Michael Patrick Keenan , David Alan Kenney , Aravind Raghavan Rammohan , Joseph Christopher Wall , Jin Wang
IPC: B01L3/02
CPC classification number: B01L3/0275 , B01L2200/12 , B01L2300/0832 , B01L2300/0848 , B01L2300/12 , B29C45/27 , B29K2023/12 , B29K2995/0097 , B29L2023/22
Abstract: A pipette tip includes a proximal end having an aperture and a proximal body region having a first internal cavity that receives a pipette member, and a distal end having an aperture and a distal body region having a second internal cavity that in operation receives and discharges a liquid aspirated by the pipette member, where the ratio of the proximal half weight of the pipette tip to the distal half weight of the pipette tip normalized to the total weight of the pipette tip has a value, defined as a thinning constant, wherein the pipette tip has a wall thickness of less than 0.022 inches over the distal region.
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Patent Agency Ranking
公开(公告)号：US20150315536A1
公开(公告)日：2015-11-05
申请号：US14647558
申请日：2013-11-27
Applicant: David Alan KENNEY , Todd Michael TON , Joseph Christopher WALL , CORNING INCORPORATED
Inventor： David Alan Kenney , Todd Michael Upton , Joseph Christopher Wall
Abstract: A flask for the culturing of cells is disclosed. The cell culture chamber is defined by top and bottom walls connected by side and end walls, one end wall shaped such that media can drain to a bottommost spot thereby allowing for the complete removal of media via a vertically oriented pipette inserted into the interior of the flask body through an open neck.
Abstract translation: 公开了一种培养细胞的烧瓶。 细胞培养室由通过侧壁和端壁连接的顶壁和底壁限定，一个端壁成形为使得介质可以排放到最下面的点，从而允许通过插入到内部的内部的垂直取向的移液管完全去除介质 瓶身通过开放的颈部。
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公开(公告)号：US20150017711A1
公开(公告)日：2015-01-15
申请号：US14375553
申请日：2013-01-31
Applicant: CORNING INCORPORATED
CPC classification number: C12M27/16 , C12M23/50 , C12M23/52 , C12M29/00 , C12M29/14 , C12M33/08 , C12M41/40 , C12M41/44 , C12M41/48
Abstract: An integrated cell culture system may include one or more cell culture vessels, manipulation apparatus, pumping apparatus, cell release apparatus, monitoring apparatus, and a control apparatus. The control apparatus may be used to monitor and control the system to facilitate effective cell culturing. The cell release apparatus may be used to release a plurality of cells adhered to the cell culture surfaces of the cell culture vessels.
Abstract translation: 综合细胞培养系统可以包括一个或多个细胞培养容器，操作装置，泵送装置，细胞释放装置，监测装置和控制装置。 控制装置可用于监测和控制系统以促进有效的细胞培养。 细胞释放装置可以用于释放粘附于细胞培养容器的细胞培养表面的多个细胞。
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公开(公告)号：US10316281B2
公开(公告)日：2019-06-11
申请号：US15691102
申请日：2017-08-30
Applicant: CORNING INCORPORATED
Abstract: A cell culture apparatus includes cell culture units having cell culture chambers, each with at least one manifold. The manifold connects the cell culture unit to a fluid flow channel. The manifold has a dam which allows liquid to pool in the manifold and allows for the creation of an airspace in the manifold, which reduces hydrostatic pressure inside the apparatus and enables the stacking of multiple cell culture units. Embodiments include cascading manifolds, manifolds having reservoirs, and manifolds having valves.
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公开(公告)号：US20170037350A1
公开(公告)日：2017-02-09
申请号：US15304313
申请日：2015-04-09
Applicant: CORNING INCORPORATED
Inventor： David Alan Kenney , Nikolaos Pantelis Kladias , Shang-Pin Kwei , Aravind Raghavan Rammohan , Joseph Christopher Wall , Kathy Marie Youngbear
CPC classification number: C12M23/08 , B01F9/0021 , B01F15/00876 , B01F2009/0092 , C12M27/20
Abstract: A 5-liter bioreactor vessel enables a substantial increase in the volume of biological media that can be cultivated in the vessel compared to conventional designs. Moreover, when agitated at 1.5× the shaking frequency of a conventional 3-liter bioreactor (i.e., 90 rpm versus 60 rpm), the 5-liter vessel achieves a 19% increase in cell aeration without exceeding the maximum shear stress limit for cell viability. The 5-liter vessel optionally includes a plurality of internal baffles configured to disrupt the liquid vortex and reduce the maximum shear stress transferred to biomedia contained within the vessel.
Abstract translation: 与常规设计相比，5升生物反应器容器能够显着增加在容器中培养的生物培养基的体积。 此外，当以常规3升生物反应器（即90rpm至60rpm）的振荡频率为1.5倍搅拌时，5升容器在不超过细胞活力的最大剪切应力极限的情况下实现细胞曝气增加19％ 。 5升容器可选地包括多个内部挡板，其构造成破坏液体涡流并减少转移到容器内所含生物媒体的最大剪切应力。
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公开(公告)号：USD748812S1
公开(公告)日：2016-02-02
申请号：US29452170
申请日：2013-04-12
Applicant: Corning Incorporated
Designer： David Alan Kenney , Joseph Christopher Wall
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