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公开(公告)号：US20230357686A1
公开(公告)日：2023-11-09
申请号：US18219266
申请日：2023-07-07
Applicant: CORNING INCORPORATED
Inventor： William Joseph Lacey , Gregory Roger Martin , Allison Jean Tanner
Abstract: A cell culture vessel includes a vessel body, support columns, and a stabilizer device. The vessel body defines a cell culture chamber enclosed between a bottom wall and a top wall. The support column is within the cell culture chamber and extends between the top wall and the bottom wall. The stabilizer device covers a width and length of the cell culture chamber and has a column engaging structure that is sized to slidingly engage the support column such that the stabilizer device is movable along the support column as a liquid culture medium is received in the cell culture chamber. The support column guides the stabilizer device along a length of the support column as the stabilizer device rises with rising liquid level in the cell culture chamber during a liquid culture medium filling operation.
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公开(公告)号：US11732227B2
公开(公告)日：2023-08-22
申请号：US16629656
申请日：2018-07-13
Applicant: CORNING INCORPORATED
Inventor： William Joseph Lacey , Gregory Roger Martin , Allison Jean Tanner
Abstract: A cell culture vessel includes a vessel body, support columns, and a stabilizer device. The vessel body defines a cell culture chamber enclosed between a bottom wall and a top wall. The support column is within the cell culture chamber and extends between the top wall and the bottom wall. The stabilizer device covers a width and length of the cell culture chamber and has a column engaging structure that is sized to slidingly engage the support column such that the stabilizer device is movable along the support column as a liquid culture medium is received in the cell culture chamber. The support column guides the stabilizer device along a length of the support column as the stabilizer device rises with rising liquid level in the cell culture chamber during a liquid culture medium filling operation.
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公开(公告)号：US20220411738A1
公开(公告)日：2022-12-29
申请号：US17779880
申请日：2020-11-04
Applicant: CORNING INCORPORATED
Inventor： Vasiliy Nikolaevich Goral , Kathleen Anne Krebs , William Joseph Lacey , Mackenzie Anna Maloney , Todd Marshall Wetherill
Abstract: A cell culture system is provided that includes a cell culture vessel having an interior cavity to house a cell culture substrate in a cell culture space, and at least one port for at least one of fluid inlet to the interior cavity and fluid outlet from the interior cavity. The system further includes a piston having a distal end disposed in the cell culture vessel above the cell culture space, the distal end of the piston being sealed with an airtight seal within the interior cavity. The system also includes a driver coupled to the piston to move the piston so as to increase and decrease a distance between the distal end and the cell culture space. The driver can pressurize the interior cavity via actuation of the piston to harvest cells from the cell culture space through the at least one port.
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公开(公告)号：US20180169547A1
公开(公告)日：2018-06-21
申请号：US15579786
申请日：2016-06-08
Applicant: Corning Incorporated
Inventor： William Joseph Lacey
Abstract: A flow-through apparatus is provided. The flow-through apparatus includes a housing having a fixed volume and having an inlet, an outlet, and a cavity. The flow-through apparatus also includes a first filter in fluid communication with the inlet and disposed within the cavity and a seal attaching the first filter to the housing. The first filter has a mesh size of about 100 microns or less and a first internal volume less than the fixed volume of the housing.
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公开(公告)号：US20250145921A1
公开(公告)日：2025-05-08
申请号：US19017078
申请日：2025-01-10
Applicant: CORNING INCORPORATED
Inventor： William Joseph Lacey , Gregory Roger Martin , Allison Jean Tanner
Abstract: A cell culture vessel includes a vessel body, support columns, and a stabilizer device. The vessel body defines a cell culture chamber enclosed between a bottom wall and a top wall. The support column is within the cell culture chamber and extends between the top wall and the bottom wall. The stabilizer device covers a width and length of the cell culture chamber and has a column engaging structure that is sized to slidingly engage the support column such that the stabilizer device is movable along the support column as a liquid culture medium is received in the cell culture chamber. The support column guides the stabilizer device along a length of the support column as the stabilizer device rises with rising liquid level in the cell culture chamber during a liquid culture medium filling operation.
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Patent Agency Ranking
公开(公告)号：US20230276791A1
公开(公告)日：2023-09-07
申请号：US18196720
申请日：2023-05-12
Applicant: CORNING INCORPORATED
Inventor： William Joseph Lacey , Gregory Roger Martin , Allison Jean Tanner
CPC classification number: A01N1/0268 , B01L3/50825 , C12M45/22 , B01L3/5082 , B01L2300/042 , B01L2300/046 , B01L2300/0858 , B01L2300/0609 , B01L2300/123 , B01L2200/141 , B01L2300/043 , B01L2300/0832
Abstract: Vial assemblies comprise a tubular body and a cap, the cap including a first portion configured to abut a lip of an open end of the tubular body, a threaded portion configured to couple to threading on an internal surface of the tubular body, and a second portion protruding from the threaded portion and extending into a cavity of the tubular body. Methods for storing and removing frozen samples from such vial assemblies are also described.
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公开(公告)号：US20180242573A1
公开(公告)日：2018-08-30
申请号：US15774883
申请日：2016-11-03
Applicant: Corning Incorporated
Inventor： William Joseph Lacey , Gregory Roger Martin , Allison Jean Tanner
CPC classification number: A01N1/0268 , B01L3/5082 , B01L3/50825 , B01L2200/141 , B01L2300/042 , B01L2300/043 , B01L2300/046 , B01L2300/0609 , B01L2300/0832 , B01L2300/0858 , B01L2300/123 , C12M45/22
Abstract: Vial assemblies comprise a tubular body and a cap, the cap including a first portion configured to abut a lip of an open end of the tubular body, a threaded portion configured to couple to threading on an internal surface of the tubular body, and a second portion protruding from the threaded portion and extending into a cavity of the tubular body. Methods for storing and removing frozen samples from such vial assemblies are also described.
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公开(公告)号：US20180125752A1
公开(公告)日：2018-05-10
申请号：US15799160
申请日：2017-10-31
Applicant: Corning Incorporated
Inventor： Michael Charles Gerrish , Yulong Hong , William Joseph Lacey , David John McEnroe , Aniello Mario Palumbo
CPC classification number: A61J1/03 , A61J1/10 , A61J1/1468 , C12M23/02 , C12M23/48
Abstract: A bio-container assembly that includes a bio-container having an interior surface, an exterior surface, and a container thickness from about 0.2 mm to about 2 mm; at least one port coupled to the bio-container; a holder element comprising a polymeric material; and a cushion affixed to the holder element in contact with one or more primary exterior surfaces of the bio-container. Further, the element and the cushion are configured to enclose the bio-container. The holder element may also include a window, the bio-container being viewable through the window. The holder element may also include one or more of the following features affixed to it: a handle, a plurality of feet, a plurality of ribs, and a plurality of tabs.
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公开(公告)号：US20240301336A1
公开(公告)日：2024-09-12
申请号：US18571999
申请日：2022-06-14
Applicant: CORNING INCORPORATED
Inventor： Thomas Albert Cloutier , William Joseph Lacey , Ana Maria del Pilar Pardo , Allison Jean Tanner
Abstract: A protective carrier for a microcavity vessel is provided. The protective carrier comprises a substantially flat rigid plate comprising a top surface and a bottom surface. A flange disposed around at least a portion of a perimeter of the rigid plate, the flange extending from the top surface of the rigid plate. One or more ribs disposed on the bottom surface of the rigid plate. A protective microcavity vessel carrier system is provided that comprises a microcavity vessel comprising a microcavity substrate on a bottom surface; and a protective carrier. The microcavity vessel may be a microcavity flask, microcavity plate such as an open well reservoir plate, microcavity bioreactor, or a stacked 3D microcavity culture vessel.
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公开(公告)号：US20240091778A1
公开(公告)日：2024-03-21
申请号：US18525119
申请日：2023-11-30
Applicant: CORNING INCORPORATED
Inventor： William Joseph Lacey , Gregory Roger Martin , Ana Maria del Pilar Pardo , Allison Jean Tanner
CPC classification number: B01L3/5085 , C12M23/08 , C12M23/38 , B01L2300/0858
Abstract: A cell culture vessel has a wall and cell culture surface having a plurality of microcavities for culturing cells in three-dimensional conformation, referred to as “spheroids”. The inner surface of the wall and the cell culture surface define a cell culture chamber of the vessel. The wall is attached to the cell culture surface in a way that does not provide flat surfaces on or around the cell culture surface so that the vessel provides an environment suitable for the production of a homogeneous population of three-dimensional cell clusters, or spheroids.
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