公开(公告)号：US12029818B2

公开(公告)日：2024-07-09

申请号：US17812479

申请日：2022-07-14

申请人： CRITITECH, INC.

发明人： Jacob Sittenauer ,  Joseph Farthing ,  Mark Williams ,  Michael Baltezor ,  Gere Dizerega ,  Aranza Barreda Abarca ,  Shelby Clark

IPC分类号： A61K9/14 ,  A61K31/5365 ,  A61K47/26

CPC分类号： A61K9/14 ,  A61K31/5365 ,  A61K47/26

摘要： The disclosure provides particles of at least 95% by weight of lapatinib, or a pharmaceutically acceptable salt thereof, wherein the particles have a specific surface area (SSA) of at least 10 m2/g and have a mean particle size by volume distribution of between about 0.7 μm and about 8 μm.

公开(公告)号：US11104663B2

公开(公告)日：2021-08-31

申请号：US16650670

申请日：2018-09-28

申请人： CRITITECH, INC.

发明人： Mark Williams ,  Jacob Sittenauer ,  Shelby Clark ,  Joseph Farthing ,  Michael Baltezor ,  Matthew McClorey

IPC分类号： C07D401/10 ,  A61K9/14 ,  A61K9/00 ,  A61P31/04

摘要： The present disclosure relates to ciprofloxacin polymorphs and their use in treating infections.

公开(公告)号：US10507195B2

公开(公告)日：2019-12-17

申请号：US15895197

申请日：2018-02-13

申请人： CRITITECH, INC.

发明人： Michael Baltezor ,  Joseph Farthing ,  Jake Sittenauer ,  Jahna Espinosa ,  Samuel Campbell ,  Matthew McClorey ,  Julia K. Fischer ,  Mark D. Williams ,  Gary Clapp

IPC分类号： A61K31/337 ,  A61K9/00 ,  A61K9/10 ,  A61K9/14 ,  A61K9/16 ,  A61K9/51 ,  A61J3/02 ,  B01J19/10 ,  B01J19/26 ,  B01J2/04 ,  B01J3/00 ,  B01J4/00 ,  B01D46/24 ,  B01J3/02 ,  B05B1/34 ,  B05B13/02

摘要： Compositions are provided that include having at least 95% by weight of a taxane, or a pharmaceutically acceptable salt thereof, where the particles have a mean bulk density between about 0.050 g/cm3 and about 0.15 g/cm3, and/or a specific surface area (SSA) of at least 18 m2/g, 20 m2/g, 25 m2/g, 30 m2/g, 32 m2/g, 34 m2/g, or 35 m2/g. Methods for making and using such compositions are also provided.

公开(公告)号：US09814685B2

公开(公告)日：2017-11-14

申请号：US15174505

申请日：2016-06-06

申请人： CRITITECH, INC.

发明人： Michael Baltezor ,  Joseph Farthing ,  Jake Sittenauer ,  Jahna Espinosa ,  Samuel Campbell ,  Matthew McClorey ,  Julia K. Fischer ,  Mark D. Williams ,  Gary E. Clapp

IPC分类号： A61K9/51 ,  A61K9/16 ,  A61K31/337 ,  B01J2/04 ,  B01J19/26 ,  B01J19/10 ,  B01J4/00 ,  A61K9/14 ,  A61K9/10 ,  A61K9/00 ,  B01J3/00

CPC分类号： A61K31/337 ,  A61J3/02 ,  A61K9/0019 ,  A61K9/10 ,  A61K9/14 ,  A61K9/1605 ,  A61K9/1682 ,  A61K9/1688 ,  A61K9/5192 ,  B01D46/24 ,  B01D2271/02 ,  B01J2/04 ,  B01J3/008 ,  B01J3/02 ,  B01J4/002 ,  B01J19/10 ,  B01J19/26 ,  B05B1/3489 ,  B05B13/0278 ,  B05D2401/90

摘要： Compositions are provided that include having at least 95% by weight of a taxane, or a pharmaceutically acceptable salt thereof, where the particles have a mean bulk density between about 0.050 g/cm3 and about 0.15 g/cm3, and/or a specific surface area (SSA) of at least 18 m2/g, 20 m2/g, 25 m2/g, 30 m2/g, 32 m2/g, 34 m2/g, or 35 m2/g. Methods for making and using such compositions are also provided.

公开(公告)号：US20240156861A1

公开(公告)日：2024-05-16

申请号：US18492232

申请日：2023-10-23

申请人： CRITITECH, INC.

发明人： Michael Baltezor ,  Holly Maulhardt ,  Maria Montes-Gonzalez ,  Jahna Espinosa ,  Mark Williams ,  Joseph Farthing ,  Jacob Sittenauer

IPC分类号： A61K33/243 ,  A61K9/10 ,  A61K47/10 ,  A61P35/00

CPC分类号： A61K33/243 ,  A61K9/10 ,  A61K47/10 ,  A61P35/00

摘要： Suspensions and their use for treating tumors are provided, where the suspensions include (a) particles of at least 95% by weight of cisplatin, wherein the particles have a specific surface area (SSA) of at least 3.5 m2/g, (b) about 40% to about 60% w/w of glycerin, (c) about 20% to about 40% w/w of propylene glycol, (d) about 5% to about 20% w/w of ethanol, and (e) about 5% to about 10% w/w of 0.9% sodium chloride in water.

公开(公告)号：US20180353630A1

公开(公告)日：2018-12-13

申请号：US16064258

申请日：2016-12-23

申请人： CritiTech, Inc.

发明人： Joseph Farthing ,  Michael Baltezor

IPC分类号： A61L2/00

CPC分类号： A61L2/0088 ,  A61L2/0011 ,  A61L2/0082 ,  A61L2/025 ,  A61L2/16 ,  A61L2202/15 ,  A61L2202/21 ,  A61N7/00

摘要： Disclosed here are methods for tissue sterilization involving producing sonic energy from one or more sonic energy sources located at least partially within a pressurized chamber; and contacting a biological tissue positioned in the pressurized chamber with a supercritical fluid for a first time period effective to sterilize the biological tissue, where the contacting occurs exclusively at a temperature and pressure at or above the critical point of the supercritical fluid.

公开(公告)号：US11123322B2

公开(公告)日：2021-09-21

申请号：US16669310

申请日：2019-10-30

申请人： CRITITECH, INC.

发明人： Michael Baltezor ,  Joseph Farthing ,  Jake Sittenauer ,  Jahna Espinosa ,  Samuel Campbell ,  Matthew McClorey ,  Julia K. Fischer ,  Mark D. Williams ,  Gary E. Clapp

IPC分类号： A61K31/337 ,  A61K9/00 ,  A61K9/10 ,  A61K9/14 ,  A61K9/16 ,  A61K9/51 ,  B01J19/10 ,  B01J19/26 ,  B01J2/04 ,  B01J3/00 ,  B01J4/00 ,  A61J3/02 ,  B01D46/24 ,  B01J3/02 ,  B05B1/34 ,  B05B13/02

摘要： Compositions are provided that include having at least 95% by weight of a taxane, or a pharmaceutically acceptable salt thereof, where the particles have a mean bulk density between about 0.050 g/cm3 and about 0.15 g/cm3, and/or a specific surface area (SSA) of at least 18 m2/g, 20 m2/g, 25 m2/g, 30 m2/g, 32 m2/g, 34 m2/g, or 35 m2/g. Methods for making and using such compositions are also provided.

公开(公告)号：US09918957B2

公开(公告)日：2018-03-20

申请号：US15499397

申请日：2017-04-27

申请人： CRITITECH, INC.

发明人： Michael Baltezor ,  Joseph Farthing ,  Jake Sittenauer ,  Jahna Espinosa ,  Samuel Campbell ,  Matthew McClorey ,  Julia K. Fischer ,  Mark D. Williams

IPC分类号： A61K31/337 ,  A61K9/16 ,  B01J3/02 ,  B01J3/00

CPC分类号： A61K31/337 ,  A61J3/02 ,  A61K9/0019 ,  A61K9/10 ,  A61K9/14 ,  A61K9/1605 ,  A61K9/1682 ,  A61K9/1688 ,  A61K9/5192 ,  B01D46/24 ,  B01D2271/02 ,  B01J2/04 ,  B01J3/008 ,  B01J3/02 ,  B01J4/002 ,  B01J19/10 ,  B01J19/26 ,  B05B1/3489 ,  B05B13/0278 ,  B05D2401/90

摘要： Compositions are provided that include having at least 95% by weight of a taxane, or a pharmaceutically acceptable salt thereof, where the particles have a mean bulk density between about 0.050 g/cm3 and about 0.15 g/cm3, and/or a specific surface area (SSA) of at least 18 m2/g, 20 m2/g, 25 m2/g, 30 m2/g, 32 m2/g, 34 m2/g, or 35 m2/g. Methods for making and using such compositions are also provided.

公开(公告)号：US11738029B2

公开(公告)日：2023-08-29

申请号：US18053557

申请日：2022-11-08

申请人： CRITITECH, INC.

发明人： Jacob Sittenauer ,  Aranza Barreda Abarca ,  Shelby Clark ,  Joseph Farthing ,  Mark Williams ,  Gere Dizerega ,  Michael Baltezor

IPC分类号： A61K31/55 ,  A61K9/16

CPC分类号： A61K31/55 ,  A61K9/16 ,  A61K9/1688

摘要： Compositions of particles having at least 95% by weight of rucaparib and a specific surface area (SSA) of at least 12 m2/g, methods for their use, and methods for their production are provided.

公开(公告)号：US11738014B2

公开(公告)日：2023-08-29

申请号：US18053491

申请日：2022-11-08

申请人： CRITITECH, INC.

发明人： Jacob Sittenauer ,  Aranza Barreda Abarca ,  Shelby Clark ,  Joseph Farthing ,  Mark Williams ,  Gere Dizerega ,  Michael Baltezor

IPC分类号： A61K31/454 ,  A61K9/16 ,  A61K9/00

CPC分类号： A61K31/454 ,  A61K9/008 ,  A61K9/1688

摘要： Compositions of particles having at least 95% by weight of niraparib and a specific surface area (SSA) of at least 5 m2/g, methods for their use, and methods for their production are provided.