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公开(公告)号：US10426961B2
公开(公告)日：2019-10-01
申请号：US15958985
申请日：2018-04-20
摘要： Systems and methods are provided for delivering neurostimulation therapies to patients for treating chronic heart failure. A computer-implemented control system is operated to automatically identify a neural fulcrum zone based on a monitored patient physiological response. Ongoing neurostimulation therapy is delivered within the neural fulcrum zone.
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公开(公告)号：US10166391B2
公开(公告)日：2019-01-01
申请号：US15805062
申请日：2017-11-06
摘要： Systems and methods are provided for delivering neurostimulation therapies to patients for treating chronic heart failure. A neural fulcrum zone is identified and ongoing neurostimulation therapy is delivered within the neural fulcrum zone. The implanted stimulation device includes a physiological sensor for monitoring the patient's response to the neurostimulation therapy on an ambulatory basis over extended periods of time and a control system for adjusting stimulation parameters to maintain stimulation in the neural fulcrum zone based on detected changes in the physiological response to stimulation.
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3.发明申请公开(公告)号：US20180361158A1
公开(公告)日：2018-12-20
申请号：US16009099
申请日：2018-06-14
摘要： Multi-modal stimulation therapy may be utilized in which two or more stimulation therapies having different stimulation parameters may be delivered to a single patient. This can preferentially stimulate different nerve fiber types and drive different functional responses in the target organs. The stimulation parameters that may vary between the different stimulation therapies include, for example, pulse frequency, pulse width, pulse amplitude, and duty cycle.
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4.发明申请公开(公告)号：US20180304080A1
公开(公告)日：2018-10-25
申请号：US16016422
申请日：2018-06-22
申请人： CYBERONICS, INC.
发明人： Imad Libbus , Badri Amurthur , Bruce H. KenKnight
CPC分类号： A61N1/36114 , A61B5/0205 , A61B5/0245 , A61B5/0452 , A61B5/0464 , A61B5/08 , A61B5/0816 , A61B5/1118 , A61B5/4809 , A61B5/4812 , A61B5/4836 , A61B5/686 , A61N1/0551 , A61N1/36053 , A61N1/36057 , A61N1/36139 , A61N1/36157 , A61N1/36171 , A61N1/36175 , A61N1/3621
摘要： An implantable neurostimulator-implemented method for managing tachyarrhythmias upon a patient's awakening from sleep through vagus nerve stimulation is provided. An implantable neurostimulator, including a pulse generator, is configured to deliver electrical therapeutic stimulation in a manner that results in creation and propagation (in both afferent and efferent directions) of action potentials within neuronal fibers comprising the cervical vagus nerve of a patient. Operating modes of the pulse generator are stored. An enhanced dose of the electrical therapeutic stimulation is parametrically defined and tuned to prevent initiation of or disrupt tachyarrhythmia upon the patient's awakening from a sleep state through at least one of continuously-cycling, intermittent and periodic ON-OFF cycles of electrical pulses. Other operating modes, including a maintenance dose and a restorative dose are defined. The patient's physiological state is monitored via at least one sensor to detect that patient's awakening, which activates the delivery of the enhanced dose.
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公开(公告)号：US09950169B2
公开(公告)日：2018-04-24
申请号：US14262270
申请日：2014-04-25
CPC分类号： A61N1/36139 , A61N1/36053 , A61N1/36114 , A61N1/36146 , A61N1/36157 , A61N1/36171 , A61N1/3627
摘要： Systems and methods are provided for delivering neurostimulation therapies to patients for treating chronic heart failure. A computer-implemented control system is operated to automatically identify a neural fulcrum zone based on a monitored patient physiological response. Ongoing neurostimulation therapy is delivered within the neural fulcrum zone.
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6.发明授权公开(公告)号：US09713719B2
公开(公告)日：2017-07-25
申请号：US14255276
申请日：2014-04-17
CPC分类号： A61N1/36139 , A61N1/36053 , A61N1/36114 , A61N1/36157 , A61N1/36171 , A61N1/3627
摘要： Systems and methods are provided for delivering neurostimulation therapies to patients for treating chronic heart failure. A neural fulcrum zone is identified and ongoing neurostimulation therapy is delivered within the neural fulcrum zone. This neural fulcrum zone may be identified by monitoring a patient's response to incrementally increased intensity settings at a first frequency. If the incremental intensity increases do not result in the identification of the neural fulcrum zone, the frequency may be changed to provide finer resolution identification of the neural fulcrum zone.
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公开(公告)号：US09643008B2
公开(公告)日：2017-05-09
申请号：US13673795
申请日：2012-11-09
申请人： CYBERONICS, INC.
发明人： Imad Libbus , Badri Amurthur , Bruce H. KenKnight
CPC分类号： A61N1/36114 , A61B5/1118 , A61B5/4836 , A61N1/36053 , A61N1/36139 , A61N1/3621
摘要： An implantable neurostimulator-implemented method for enhancing post-exercise recovery through vagus nerve stimulation is provided. An implantable neurostimulator, including a pulse generator configured to deliver electrical therapeutic stimulation in a manner that results in creation and propagation (in both afferent and efferent directions) of action potentials within neuronal fibers including a patient's cervical vagus nerve. An operating mode is stored in the pulse generator. An enhanced dose of the electrical therapeutic stimulation is parametrically defined and tuned to prevent or disrupt tachyarrhythmia through continuously-cycling, intermittent and periodic electrical pulses. The patient's physiological state is monitored during physical exercise via at least one sensor included in the implantable neurostimulator, and upon sensing a condition indicative of cessation of the physical exercise, the enhanced dose is delivered for a period of time the enhanced dose to the vagus nerve.
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8.发明申请RESPONSIVE NEUROSTIMULATION FOR THE TREATMENT OF CHRONIC CARDIAC DYSFUNCTION 有权用于治疗慢性心脏功能障碍的反应性神经病学公开(公告)号：US20170001012A1
公开(公告)日：2017-01-05
申请号：US15267922
申请日：2016-09-16
CPC分类号： A61N1/36114 , A61N1/36053 , A61N1/36135 , A61N1/36139 , A61N1/3615 , A61N1/37217 , A61N1/37264
摘要： Systems and methods are provided for delivering neurostimulation therapies to patients for treating chronic heart failure. A neural fulcrum zone is identified and ongoing neurostimulation therapy is delivered within the neural fulcrum zone. The implanted stimulation device includes a physiological sensor for monitoring the patient's response to the neurostimulation therapy on an ambulatory basis over extended periods of time and a control system for adjusting stimulation parameters to maintain stimulation in the neural fulcrum zone based on detected changes in the physiological response to stimulation.
摘要翻译： 提供系统和方法用于向患者提供神经刺激疗法用于治疗慢性心力衰竭。 识别神经支点区域，并在神经支点区域内递送正在进行的神经刺激治疗。 植入的刺激装置包括生理传感器，用于在延长的时间段内基于动态监测患者对神经刺激疗法的反应，以及控制系统，用于根据检测到的生理反应的变化调整刺激参数以维持神经支点区域中的刺激 刺激。
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公开(公告)号：US20160346549A1
公开(公告)日：2016-12-01
申请号：US15236039
申请日：2016-08-12
CPC分类号： A61N1/36139 , A61N1/0551 , A61N1/36053 , A61N1/36114 , A61N1/36146 , A61N1/36157 , A61N1/36171 , A61N1/3627
摘要： Systems and methods are provided for delivering neurostimulation therapies to patients for treating chronic heart failure. A neural fulcrum zone is identified and ongoing neurostimulation therapy is delivered within the neural fulcrum zone. The implanted stimulation device includes a physiological sensor for recording the patient's response to the neurostimulation therapy on an ambulatory basis over extended periods of time.
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公开(公告)号：US20160045754A1
公开(公告)日：2016-02-18
申请号：US14457843
申请日：2014-08-12
申请人： CYBERONICS, INC.
CPC分类号： A61N1/3962 , A61N1/0504 , A61N1/0556 , A61N1/0587 , A61N1/36053 , A61N1/36114 , A61N1/36139 , A61N1/3615 , A61N1/3627 , A61N1/3756 , A61N1/3987
摘要： Systems and methods are provided for delivering vagus nerve stimulation and cardioversion/defibrillation therapies to patients for treating chronic heart failure. The vagus nerve stimulation and cardioversion/defibrillation therapies may be provided using a single implantable pulse generator, which can coordinate delivery of the therapies to provide an acute vagus nerve stimulation therapy in advance of delivering cardioversion-defibrillation energy.
摘要翻译： 提供系统和方法用于将迷走神经刺激和心脏复律/除颤疗法提供给患者用于治疗慢性心力衰竭。 可以使用单个可植入脉冲发生器来提供迷走神经刺激和心脏复律/除颤疗法，其可以在提供心脏复律除颤能量之前协调治疗的递送以提供急性迷走神经刺激疗法。
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