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公开(公告)号：US11447508B2
公开(公告)日：2022-09-20
申请号：US16997240
申请日：2020-08-19
Abstract: The present disclosure sets forth novel compounds and compositions including heteroaromatic silicon-fluoride-acceptors, which are useful for PET scanning. The present disclosure further includes novel methods of 18F imaging for PET scanning, the methods comprising the preparation of conjugates and bioconjugates of biological ligands of interest with heteroaromatic silicon-fluoride-acceptors. In certain embodiments the invention is practiced in the form of a kit.
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公开(公告)号：US20200377528A1
公开(公告)日：2020-12-03
申请号：US16997226
申请日：2020-08-19
Applicant: California Institute Of Technology
Inventor： Anton A. Toutov , Kerry N. Betz , Andrew M. Romine , Robert H. Grubbs
IPC: C07F7/10
Abstract: The present disclosure is directed at methods of forming an N—Si silyl bond, the method comprising contacting an organic substrate comprising an aromatic amine having at least one N—H bond with a mixture comprising of (a) at least one hydrosilane and (b) at least one hydroxide or alkoxide, under conditions sufficient to form the N—Si bond. The disclosure is further directed to the compositions involved in these methods and the products that result therefrom.
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公开(公告)号：US20210363164A1
公开(公告)日：2021-11-25
申请号：US17378960
申请日：2021-07-19
Applicant: California Institute Of Technology
Inventor： Anton A. Toutov , Kerry N. Betz , Andrew M. Romine , Robert H. Grubbs
IPC: C07F7/18 , C07F7/21 , C07D235/08 , C07F7/08
Abstract: The present disclosure is directed to methods for dehydrogenatively coupled hydrosilanes and alcohols, the methods comprising contacting an organic substrate having at least one organic alcohol moiety with a mixture of at least one hydrosilane and sodium and/or potassium hydroxide, the contacting resulting in the formation of a dehydrogenatively coupled silyl ether. The disclosure further described associated compositions and methods of using the formed products.
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公开(公告)号：US20200377529A1
公开(公告)日：2020-12-03
申请号：US16997240
申请日：2020-08-19
Abstract: The present disclosure sets forth novel compounds and compositions including heteroaromatic silicon-fluoride-acceptors, which are useful for PET scanning. The present disclosure further includes novel methods of 18F imaging for PET scanning, the methods comprising the preparation of conjugates and bioconjugates of biological ligands of interest with heteroaromatic silicon-fluoride-acceptors. In certain embodiments the invention is practiced in the form of a kit.
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公开(公告)号：US20190218232A1
公开(公告)日：2019-07-18
申请号：US16244637
申请日：2019-01-10
Applicant: California Institute Of Technology
Inventor： Anton A. Toutov , Kerry N. Betz , Andrew M. Romine , Robert H. Grubbs
IPC: C07F7/10
CPC classification number: C07F7/10
Abstract: The present disclosure is directed at methods of forming an N—Si silyl bond, the method comprising contacting an organic substrate comprising an aromatic amine having at least one N—H bond with a mixture comprising of (a) at least one hydrosilane or hydrosiloxane and (b) at least one hydroxide or alkoxide, under conditions sufficient to form the N—Si bond. The disclosure is further directed to the compositions involved in these methods and the products that result therefrom.
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Patent Agency Ranking
公开(公告)号：US11773116B2
公开(公告)日：2023-10-03
申请号：US17192129
申请日：2021-03-04
Applicant: California Institute Of Technology
Inventor： Anton A. Toutov , Kerry N. Betz , Andrew M. Romine , Robert H. Grubbs
IPC: C07F7/10
CPC classification number: C07F7/10
Abstract: The present disclosure is directed to hydrosilyl amines and fluorosilyl amines and methods of making the same.
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公开(公告)号：US20230114064A1
公开(公告)日：2023-04-13
申请号：US17933234
申请日：2022-09-19
Abstract: The present disclosure sets forth novel compounds and compositions including heteroaromatic silicon-fluoride-acceptors, which are useful for PET scanning. The present disclosure further includes novel methods of 8F imaging for PET scanning, the methods comprising the preparation of conjugates and bioconjugates of biological ligands of interest with heteroaromatic silicon-fluoride-acceptors. In certain embodiments the invention is practiced in the form of a kit.
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公开(公告)号：US20210198291A1
公开(公告)日：2021-07-01
申请号：US17192129
申请日：2021-03-04
Applicant: California Institute Of Technology
Inventor： Anton A. Toutov , Kerry N. Betz , Andrew M. Romine , Robert H. Grubbs
IPC: C07F7/10
Abstract: The present disclosure is directed to hydrosilyl amines and fluorosilyl amines and methods of making the same.
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公开(公告)号：US10995105B2
公开(公告)日：2021-05-04
申请号：US16997226
申请日：2020-08-19
Applicant: California Institute Of Technology
Inventor： Anton A. Toutov , Kerry N. Betz , Andrew M. Romine , Robert H. Grubbs
IPC: C07F7/10
Abstract: The present disclosure is directed at methods of forming an N—Si silyl bond, the method comprising contacting an organic substrate comprising an aromatic amine having at least one N—H bond with a mixture comprising of (a) at least one hydrosilane and (b) at least one hydroxide or alkoxide, under conditions sufficient to form the N—Si bond. The disclosure is further directed to the compositions involved in these methods and the products that result therefrom.
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公开(公告)号：US10781221B2
公开(公告)日：2020-09-22
申请号：US16244637
申请日：2019-01-10
Applicant: California Institute of Technology
Inventor： Anton A. Toutov , Kerry N. Betz , Andrew M. Romine , Robert H. Grubbs
IPC: C07F7/10
Abstract: The present disclosure is directed at methods of forming an N—Si silyl bond, the method comprising contacting an organic substrate comprising an aromatic amine having at least one N—H bond with a mixture comprising of (a) at least one hydrosilane or hydrosiloxane and (b) at least one hydroxide or alkoxide, under conditions sufficient to form the N—Si bond. The disclosure is further directed to the compositions involved in these methods and the products that result therefrom.
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