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公开(公告)号：US11959856B2
公开(公告)日：2024-04-16
申请号：US15701014
申请日：2017-09-11
IPC分类号： G01N21/64 , C12Q1/6851
CPC分类号： G01N21/6486 , C12Q1/6851 , C12Q1/6851 , C12Q2537/143 , C12Q2537/165 , C12Q2565/629
摘要： Methods and algorithms for a multiplexed single detection channel amplification process and quantification of generated amplicons is presented. Various mathematical approaches for quantifying and verifying the amplicons in a reaction are presented. Usage of such methods and approaches allow upgrading of existing single and multiple channel instruments for further multiplexing capabilities.
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公开(公告)号：US11690544B2
公开(公告)日：2023-07-04
申请号：US17314930
申请日：2021-05-07
发明人： Samson Chen , Axel Scherer , Dvin Adalian , Peter Petillo , Muhammad Musab Jilani , Xiomara L. Madero , Deepan Kishore Kumar
IPC分类号： A61B5/145 , C12N11/02 , A61B5/1486 , C12N9/02 , A61B5/1459 , G01N27/327 , C12N11/14
CPC分类号： A61B5/14865 , A61B5/1459 , A61B5/14532 , C12N9/0004 , C12N11/02 , C12N11/14 , G01N27/3272 , C12Y101/01001 , C12Y101/0301 , C12Y101/0302 , C12Y101/03003 , C12Y101/0303 , C12Y101/0304 , C12Y101/03005 , C12Y101/03007 , C12Y101/03008 , C12Y101/03011 , C12Y101/03012 , C12Y101/03015 , C12Y101/03016 , C12Y101/03018 , C12Y101/03019 , C12Y101/03023 , C12Y101/03027 , C12Y101/03029 , C12Y101/03037 , C12Y101/03038 , C12Y101/03041
摘要： A sensor implanted in tissues and including a sensing layer is fabricated by mixing the signal transduction enzyme with non-reactive components including buffer salts and fillers, and spin coating the enzyme onto a substrate. The signal transduction enzyme is crosslinked by introducing the coated substrate in a vacuum chamber. In the chamber, a crosslinker evaporates and is deposited onto the enzyme, therefore crosslinking the enzyme.
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公开(公告)号：US20230151440A1
公开(公告)日：2023-05-18
申请号：US17810696
申请日：2022-07-05
发明人： Aditya Rajagopal , Mark D. Goldberg , Erika F. Garcia , Xiomara L. Madero , Thomas A. Tombrello , Axel Scherer
IPC分类号： C12Q1/70 , C12Q1/68 , C12Q1/6851
CPC分类号： C12Q1/701 , C12Q1/703 , C12Q1/68 , C12Q1/6851 , Y10T436/143333
摘要： A non-transitory computer-readable storage medium storing executable instructions to cause a system to detect a genetic variation in a polynucleotide analyte in a sample. A fluorophore is attached to a first primer, a quencher is attached to a second primer, and the first primer and the second primer are specific for the polynucleotide analyte. The primers are configured to amplify the polynucleotide analyte having the genetic variation and a corresponding polynucleotide analyte lacking the generic variation. There is a detectable difference between a measured change in signal generated by the fluorophore and quencher, when using the first and second primers to amplify the polynucleotide analyte with the genetic variation, and a change in signal generated by the fluorophore and quencher, when using the first and second primers to amplify the corresponding polynucleotide analyte lacking the genetic variation.
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公开(公告)号：US11635064B1
公开(公告)日：2023-04-25
申请号：US17338393
申请日：2021-06-03
申请人： California Institute of Technology , The Government of the United States of America, as represented by the Secretary of the Navy
发明人： Emil P. Kartalov , Axel Scherer
IPC分类号： A61F2/08 , H02N1/00 , B33Y80/00 , A61H1/02 , F15B21/06 , F03G7/06 , A61F2/70 , A61H3/00 , B25J9/10 , F15B15/10 , F15B13/044 , A61F2/48
摘要： Artificial muscles comprising a body of dielectric elastomer, wherein the body contains a pair of microfluidic networks are presented. Each microfluidic network includes a plurality of channels fluidically coupled via a manifold. The channels of the microfluidic networks are interdigitated and filled with conductive fluid such that each set of adjacent channels functions as the electrodes of an electroactive polymer (EAP) actuator. By using the manifolds as compliant wiring to energize the electrodes, artificial muscles in accordance with the present disclosure mitigate some or all of the reliability problems associated with prior-art artificial muscles.
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公开(公告)号：US11510573B2
公开(公告)日：2022-11-29
申请号：US16457642
申请日：2019-06-28
IPC分类号： A61B5/00 , A61B5/1473 , A61B5/145 , A61B5/1486
摘要： An implantable device having a communication system, a sensor, and a monolithic substrate is described. The monolithic substrate has an integrated sensor circuit configured to process input from the sensor into a form conveyable by the communication system.
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公开(公告)号：US11422084B2
公开(公告)日：2022-08-23
申请号：US16212499
申请日：2018-12-06
发明人： Axel Scherer , Amirhossein Nateghi , Taeyoon Jeon
IPC分类号： G01N21/03 , G01N1/42 , G01N1/44 , G01N21/17 , G01N21/25 , G01N21/35 , G01N21/3504 , G01N21/3577
摘要： The present disclosure is directed toward a measurement system capable of rapid spectroscopic and calorimetric analysis of the chemical makeup of a test sample. Systems in accordance with the present disclosure include a low-thermal-mass sample holder having a substrate whose surface has been engineered to create a large-area sample-collection surface. The sample holder includes an integrated temperature controller that can rapidly heat or cool the test sample. As a result, the sample holder enables differential scanning calorimetry Fourier-Transform Infrared Spectroscopy (DSC-FTIR) that can be performed in minutes rather than hours, as required in the prior art.
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公开(公告)号：US11414716B2
公开(公告)日：2022-08-16
申请号：US16827590
申请日：2020-03-23
发明人： Aditya Rajagopal , Mark D. Goldberg , Erika F. Garcia , Xiomara L. Madero , Thomas A. Tombrello , Axel Scherer
IPC分类号： C12P19/34 , C12Q1/70 , C12Q1/68 , C12Q1/6851
摘要： Medical systems for detecting a genetic variation in a polynucleotide analyte in a sample. A fluorophore is attached to a first primer, a quencher is attached to a second primer, and the first primer and the second primer are specific for the polynucleotide analyte. The primers are configured to amplify the polynucleotide analyte having the genetic variation and a corresponding polynucleotide analyte lacking the generic variation. There is a detectable difference between a change in signal generated by the fluorophore and quencher, and measured by a sensor of the medical system, when using the first and second primers to amplify the polynucleotide analyte with the genetic variation, and a change in signal generated by the fluorophore and quencher, and measured by the sensor of the medical system, when using the first and second primers to amplify the corresponding polynucleotide analyte lacking the genetic variation.
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公开(公告)号：US11304893B2
公开(公告)日：2022-04-19
申请号：US16044124
申请日：2018-07-24
摘要： An implantable device contains a drug or biosensing compound, protected from the external environment within a human body by several barriers which are broken upon activation of the device through electrothermal, chemical, and mechanical processes. The device allows accurate and repeated dosing within a human body, thus reducing the number of implantation procedures required. This device extends the lifetime of a biosensor, reducing the number of implantation procedures required.
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公开(公告)号：US11287322B2
公开(公告)日：2022-03-29
申请号：US16782674
申请日：2020-02-05
发明人： Axel Scherer , Taeyoon Jeon
摘要： An infrared spectrometer for operation in the mid-infrared spectral range is presented, where the spectrometer includes a Bragg-mirror-based spectral filter that is operative for providing an interrogation signal whose spectral content is dispersed along a first direction at a filter aperture. The filter aperture is imaged through a sample by a thermal-imaging camera to create a focused image that is based on the interrogation signal and the absorption characteristics of the sample. As a result, embodiments in accordance with the present disclosure can be smaller, less complex, and less expensive than infrared spectrometers known in the prior art.
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公开(公告)号：US11162934B2
公开(公告)日：2021-11-02
申请号：US15913704
申请日：2018-03-06
发明人： Axel Scherer
IPC分类号： G01N33/483 , A61B5/00 , G01N27/414 , A61F13/00 , A61B5/0531 , A61B5/145 , A61B5/1473 , A61B5/1486
摘要： A sensing chip attached to a bandage monitors the healing process of a wound by detecting growth factors, thrombin and fibrinogen. The complementary metal-oxide semiconductor includes a functionalized working electrode, functionalized counter electrode and functionalized reference electrode. The healing progress is stimulated by generating oxygen in the wound.
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