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1.发明申请公开(公告)号：US20220290208A1
公开(公告)日：2022-09-15
申请号：US17826637
申请日：2022-05-27
发明人： Ian M. White , Stephen Restaino , Marina Pranda
IPC分类号： C12Q1/24
摘要： The present invention relates to methods and systems for cell lysis in a microfluidic device. More specifically, embodiments of the present invention relate to methods and systems for rapid continuous flow pathogen cell lysis. In one embodiment, the microfluidic device comprises a microfluidic channel, a microporous structure within the channel, and an enzyme immobilized on the surface of the microporous structure configured to lyse pathogen cells in fluid flowing through the microfluidic channel.
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公开(公告)号：US20210037813A1
公开(公告)日：2021-02-11
申请号：US16963446
申请日：2019-01-18
发明人： Joseph R. Scalea , Stephen Restaino
摘要： Techniques are provided for the monitoring and transport of an anatomical organ with a sleeve arranged snuggly around the organ and comprising a porous material with respect to an aqueous solution in a container affixed to unmanned aerial vehicle. As a non-limiting example, in a first set of embodiments, the sleeve, shaped to an approximate shape of the target anatomical organ has an opening for inserting the target anatomical organ. The sleeve may comprise a fabric that is porous with respect to an aqueous solution and has a tensile strength to hold the weight of the sleeve and of the target anatomical organ. In other embodiments, the fabric of the sleeve may also include a different second opening for passing a blood vessel for the target anatomical organ. Further, the sleeve may include a wireless communication device and a at least one of a temperature sensor and vibration sensor.
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公开(公告)号：US20200179631A1
公开(公告)日：2020-06-11
申请号：US16707949
申请日：2019-12-09
摘要： A method and apparatus is provided for automatic emergency airway detection. The apparatus includes a frame with a carriage guide configured to be secured around a neck of a subject. A carriage including a sensor is configured to move along the carriage guide. The sensor is configured to measure a value of a parameter indicating a topography of the neck of the subject. A processor includes a memory with instructions to receive first data from the sensor of the value of the parameter as the carriage is moved along the carriage guide and to determine, with the first data, second data indicating a position along the carriage guide corresponding to the cricothyroid region of the neck. The processor subsequently transmits a first signal indicating the second data. A method of using the apparatus is also provided.
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4.发明授权公开(公告)号：US11345944B2
公开(公告)日：2022-05-31
申请号：US14586499
申请日：2014-12-30
发明人： Ian M. White , Stephen Restaino , Marina Pranda
摘要： The present invention relates to methods and systems for cell lysis in a microfluidic device. More specifically, embodiments of the present invention relate to methods and systems for rapid continuous flow pathogen cell lysis. In one embodiment, the microfluidic device comprises a microfluidic channel, a microporous structure within the channel, and an enzyme immobilized on the surface of the microporous structure configured to lyse pathogen cells in fluid flowing through the microfluidic channel.
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公开(公告)号：US20200345267A1
公开(公告)日：2020-11-05
申请号：US16964736
申请日：2019-01-24
发明人： Amal Isaiah , Jeffrey S. Wolf , Stephen Restaino
摘要： A method and system detects a hypoxic condition during an obstruction of an airway of a subject to detect and treat obstructive sleep apnea (OSA) in the subject. The method and system includes an organ stimulating transducer configured for placement in a vicinity of an organ of the subject to stimulate the organ and remove the obstruction when OSA is detected.
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