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公开(公告)号：US20220296904A1
公开(公告)日：2022-09-22
申请号：US17835302
申请日：2022-06-08
摘要： Various aspects of the present subject matter relate to an implantable device. Various device embodiments comprise at least one port to connect to at least one lead with at least electrode, stimulation circuitry connected to the at least one port and adapted to provide at least one neural stimulation therapy to at least one neural stimulation target using the at least one electrode, sensing circuitry connected to the at least one port and adapted to provide a sensed signal, and a controller connected to the stimulation circuitry to provide the at least one neural stimulation therapy and to the sensing circuitry to receive the sensed signal. In response to a triggering event, the controller is adapted to switch between at least two modes. Other aspects and embodiments are provided herein.
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公开(公告)号：US11369794B2
公开(公告)日：2022-06-28
申请号：US16597620
申请日：2019-10-09
摘要： Various aspects of the present subject matter relate to an implantable device. Various device embodiments comprise at least one port to connect to at least one lead with at least electrode, stimulation circuitry connected to the at least one port and adapted to provide at least one neural stimulation therapy to at least one neural stimulation target using the at least one electrode, sensing circuitry connected to the at least one port and adapted to provide a sensed signal, and a controller connected to the stimulation circuitry to provide the at least one neural stimulation therapy and to the sensing circuitry to receive the sensed signal. In response to a triggering event, the controller is adapted to switch between at least two modes. Other aspects and embodiments are provided herein.
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公开(公告)号：US20170319855A1
公开(公告)日：2017-11-09
申请号：US15660384
申请日：2017-07-26
发明人： Andrew P. Kramer , Jason J. Hamann
摘要： In various method embodiments for operating an implantable neural stimulator to deliver a neural stimulation therapy to an autonomic neural target, the method comprises using the implantable neural stimulator to deliver the neural stimulation therapy to the autonomic neural target, and evaluating an evoked response to the neural stimulation bursts. The neural stimulation therapy includes a plurality of neural stimulation bursts where each neural stimulation burst includes a plurality of neural stimulation pulses and successive neural stimulation bursts are separated by a time without neural stimulation pulses. Evaluating the evoked response includes sensing the evoked response to the neural stimulation bursts where sensing the evoked response includes sensing at least one physiological parameter affected by the neural stimulation bursts, comparing the sensed evoked response against a baseline, and determining if the evoked response substantially returns to the baseline between neural stimulation bursts.
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公开(公告)号：US20170266439A1
公开(公告)日：2017-09-21
申请号：US15479082
申请日：2017-04-04
发明人： Allan Charles Shuros , Tamara Colette Baynham , Jihong Qu , Joseph M. Pastore , Andrew P. Kramer , Frits W. Prinzen , Ward Y. R. Vanagt , Richard N. Cornelussen
CPC分类号： A61N1/362 , A61B17/22 , A61B18/1492 , A61B2017/22001 , A61B2018/00214 , A61B2018/0041 , A61B2018/00422 , A61N1/056 , A61N1/3625 , A61N5/1001 , A61N2001/0585
摘要： A system for use during revascularization includes a catheter having an adjustable balloon for delivery a stent, one or more pacing electrodes for delivering one or more pacing pulses to a patient's heart, and a pacemaker configured to generate the one or more pacing pulses to be delivered to the heart via the one or more pacing electrodes. The one or more pacing pulses are delivered at a rate substantially higher than the patient's intrinsic heart rate without being synchronized to the patient's intrinsic cardiac contractions, and are delivered before, during, or after an ischemic event to prevent or reduce cardiac injury.
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公开(公告)号：US09649495B2
公开(公告)日：2017-05-16
申请号：US14925618
申请日：2015-10-28
发明人： Allan Charles Shuros , Tamara Colette Baynham , Jihong Qu , Joseph M. Pastore , Andrew P. Kramer , Frits W. Prinzen , Ward Y. R. Vanagt , Richard N. Cornelussen
CPC分类号： A61N1/362 , A61B17/22 , A61B18/1492 , A61B2017/22001 , A61B2018/00214 , A61B2018/0041 , A61B2018/00422 , A61N1/056 , A61N1/3625 , A61N5/1001 , A61N2001/0585
摘要： A system for use during revascularization includes a catheter having an adjustable balloon for delivery a stent, one or more pacing electrodes for delivering one or more pacing pulses to a patient's heart, and a pacemaker configured to generate the one or more pacing pulses to be delivered to the heart via the one or more pacing electrodes. The one or more pacing pulses are delivered at a rate substantially higher than the patient's intrinsic heart rate without being synchronized to the patient's intrinsic cardiac contractions, and are delivered before, during, or after an ischemic event to prevent or reduce cardiac injury.
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公开(公告)号：US20170050026A1
公开(公告)日：2017-02-23
申请号：US15342687
申请日：2016-11-03
CPC分类号： A61N1/36128 , A61M5/1723 , A61N1/3605 , A61N1/36053 , A61N1/36114 , A61N1/36135 , A61N1/3688
摘要： Various aspects of the present subject matter relate to an implantable device. Various device embodiments comprise at least one port to connect to at least one lead with at least electrode, stimulation circuitry connected to the at least one port and adapted to provide at least one neural stimulation therapy to at least one neural stimulation target using the at least one electrode, sensing circuitry connected to the at least one port and adapted to provide a sensed signal, and a controller connected to the stimulation circuitry to provide the at least one neural stimulation therapy and to the sensing circuitry to receive the sensed signal. In response to a triggering event, the controller is adapted to switch between at least two modes. Other aspects and embodiments are provided herein.
摘要翻译： 本主题的各个方面涉及可植入装置。 各种装置实施例包括至少一个端口，以连接至少一个引线，至少电极，刺激电路连接到至少一个端口，并且适于使用至少一个至少一个端口向至少一个神经刺激目标提供至少一个神经刺激治疗 一个电极，连接到所述至少一个端口并适于提供感测信号的感测电路，以及连接到所述刺激电路以提供所述至少一个神经刺激治疗的控制器，以及所述感测电路以接收感测到的信号。 响应于触发事件，控制器适于在至少两种模式之间切换。 本文提供了其它方面和实施例。
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公开(公告)号：US09561373B2
公开(公告)日：2017-02-07
申请号：US15015491
申请日：2016-02-04
发明人： Imad Libbus , Andrew P. Kramer
CPC分类号： A61N1/36139 , A61N1/3601 , A61N1/3611 , A61N1/36114 , A61N1/36117 , A61N1/36135 , A61N1/3627 , A61N1/36535 , A61N1/36542 , A61N1/3655 , A61N1/36564 , A61N1/36571 , A61N1/37288
摘要： According to an embodiment of a method for providing neural stimulation, activity is sensed, and neural stimulation is automatically controlled based on the sensed activity. An embodiment determines periods of rest and periods of exercise using the sensed activity, and applies neural stimulation during rest and withdrawing neural stimulation during exercise. Other embodiments are provided herein.
摘要翻译： 根据用于提供神经刺激的方法的实施例，感测活动，并且基于感测的活动自动控制神经刺激。 实施例使用感测到的活动来确定休息时间和运动周期，并且在休息期间应用神经刺激并且在运动期间抽出神经刺激。 本文提供了其他实施例。
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公开(公告)号：US09504836B2
公开(公告)日：2016-11-29
申请号：US14325634
申请日：2014-07-08
CPC分类号： A61N1/37 , A61N1/36114 , A61N1/36125 , A61N1/362 , A61N1/36514 , A61N1/36564 , A61N1/36592 , A61N1/3987
摘要： Various aspects relate to a method. In various embodiments, a therapy of a first therapy type is delivered, and it is identified whether a therapy of a second therapy type is present to affect the therapy of the first therapy type. Delivery of the therapy is controlled based on the presence of the therapy of the second therapy type. Some embodiments deliver the therapy of the first type using one set of parameters in the presence of a therapy of a second type, and deliver the therapy of the first type using another set of parameters when the therapy of the second type is not present. In various embodiments, one of the therapy types includes a cardiac rhythm management therapy, and the other includes a neural stimulation therapy. Other aspects and embodiments are provided herein.
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公开(公告)号：US09504833B2
公开(公告)日：2016-11-29
申请号：US14842154
申请日：2015-09-01
发明人： Andrew P. Kramer , Jason J. Hamann
CPC分类号： A61N1/36139 , A61N1/0551 , A61N1/36053 , A61N1/36114 , A61N1/36117
摘要： In various method embodiments for operating an implantable neural stimulator to deliver a neural stimulation therapy to an autonomic neural target, the method comprises using the implantable neural stimulator to deliver the neural stimulation therapy to the autonomic neural target, and evaluating an evoked response to the neural stimulation bursts. The neural stimulation therapy includes a plurality of neural stimulation bursts where each neural stimulation burst includes a plurality of neural stimulation pulses and successive neural stimulation bursts are separated by a time without neural stimulation pulses. Evaluating the evoked response includes sensing the evoked response to the neural stimulation bursts where sensing the evoked response includes sensing at least one physiological parameter affected by the neural stimulation bursts, comparing the sensed evoked response against a baseline, and determining if the evoked response substantially returns to the baseline between neural stimulation bursts.
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公开(公告)号：US09486631B2
公开(公告)日：2016-11-08
申请号：US14318785
申请日：2014-06-30
CPC分类号： A61N1/36128 , A61M5/1723 , A61N1/3605 , A61N1/36053 , A61N1/36114 , A61N1/36135 , A61N1/3688
摘要： Various aspects of the present subject matter relate to an implantable device. Various device embodiments comprise at least one port to connect to at least one lead with at least electrode, stimulation circuitry connected to the at least one port and adapted to provide at least one neural stimulation therapy to at least one neural stimulation target using the at least one electrode, sensing circuitry connected to the at least one port and adapted to provide a sensed signal, and a controller connected to the stimulation circuitry to provide the at least one neural stimulation therapy and to the sensing circuitry to receive the sensed signal. In response to a triggering event, the controller is adapted to switch between at least two modes. Other aspects and embodiments are provided herein.
摘要翻译： 本主题的各个方面涉及可植入装置。 各种装置实施例包括至少一个端口，以连接至少一个引线，至少电极，刺激电路连接到至少一个端口，并且适于使用至少一个至少一个端口向至少一个神经刺激目标提供至少一个神经刺激治疗 一个电极，连接到所述至少一个端口并适于提供感测信号的感测电路，以及连接到所述刺激电路以提供所述至少一个神经刺激治疗的控制器，以及所述感测电路以接收感测到的信号。 响应于触发事件，控制器适于在至少两种模式之间切换。 本文提供了其它方面和实施例。
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