公开(公告)号：US09415193B2

公开(公告)日：2016-08-16

申请号：US13603296

申请日：2012-09-04

申请人： Carey V. Campbell ,  Robert L. Cleek ,  Daniel L. Crandall ,  James F. Davidson ,  Paul D. Drumheller ,  Cody L. Hartman ,  Theresa A. Holland ,  Thane L. Kranzler ,  Mei Li ,  Gregory LoStracco ,  Bruce M. Steinhaus ,  Benjamin M. Trapp ,  Thomas G. Triebes

发明人： Carey V. Campbell ,  Robert L. Cleek ,  Daniel L. Crandall ,  James F. Davidson ,  Paul D. Drumheller ,  Cody L. Hartman ,  Theresa A. Holland ,  Thane L. Kranzler ,  Mei Li ,  Gregory LoStracco ,  Bruce M. Steinhaus ,  Benjamin M. Trapp ,  Thomas G. Triebes

IPC分类号： A61M25/10 ,  A61L29/08 ,  A61L29/16

CPC分类号： A61M25/10 ,  A61L29/085 ,  A61L29/16 ,  A61L2300/602 ,  A61M2025/105 ,  A61M2025/1081 ,  F04C2270/0421

摘要： The invention is directed to eluting medical devices that enable consistent “on-demand” delivery of therapeutic agents to a vessel. The medical device of the current invention comprises an expandable member, a hydrophilic coating comprising at least one therapeutic agent about the expandable member or structural layer and an outer sheath with a variably permeable microstructure. The design and methods disclosed herein ensures that therapeutic agent delivery occurs essentially only during expansion of the expandable member, minimizing coating and/or therapeutic agent loss to the bloodstream and providing controlled delivery to the treatment site.

摘要翻译： 本发明涉及洗脱能够使治疗剂向血管进行一致“按需”递送的医疗装置。 本发明的医疗装置包括可膨胀构件，亲水性涂层，其包括围绕可膨胀构件或结构层的至少一种治疗剂和具有可变可渗透微结构的外护套。 本文公开的设计和方法确保治疗剂递送基本上仅在可膨胀构件的膨胀期间发生，使涂覆和/或治疗剂对血流的损失最小化并提供受控递送至治疗部位。

公开(公告)号：US20130253426A1

公开(公告)日：2013-09-26

申请号：US13603296

申请日：2012-09-04

申请人： Carey V. Campbell ,  Robert L. Cleek ,  Daniel L. Crandall ,  James F. Davidson ,  Paul D. Drumheller ,  Cody L. Hartman ,  Theresa A. Holland ,  Thane L. Krazler ,  Mei Li ,  Gregory LoStracco ,  Bruce M. Steinhaus ,  Benjamin M. Trapp ,  Thomas G. Triebes

发明人： Carey V. Campbell ,  Robert L. Cleek ,  Daniel L. Crandall ,  James F. Davidson ,  Paul D. Drumheller ,  Cody L. Hartman ,  Theresa A. Holland ,  Thane L. Krazler ,  Mei Li ,  Gregory LoStracco ,  Bruce M. Steinhaus ,  Benjamin M. Trapp ,  Thomas G. Triebes

IPC分类号： A61M25/10

CPC分类号： A61M25/10 ,  A61L29/085 ,  A61L29/16 ,  A61L2300/602 ,  A61M2025/105 ,  A61M2025/1081 ,  F04C2270/0421

摘要： The invention is directed to eluting medical devices that enable consistent “on-demand” delivery of therapeutic agents to a vessel. The medical device of the current invention comprises an expandable member, a hydrophilic coating comprising at least one therapeutic agent about the expandable member or structural layer and an outer sheath with a variably permeable microstructure. The design and methods disclosed herein ensures that therapeutic agent delivery occurs essentially only during expansion of the expandable member, minimizing coating and/or therapeutic agent loss to the bloodstream and providing controlled delivery to the treatment site.

摘要翻译： 本发明涉及洗脱能够使治疗剂向血管进行一致“按需”递送的医疗装置。 本发明的医疗装置包括可膨胀构件，亲水性涂层，其包括围绕可膨胀构件或结构层的至少一种治疗剂和具有可变可渗透微结构的外护套。 本文公开的设计和方法确保治疗剂递送基本上仅在可膨胀构件的膨胀期间发生，使涂覆和/或治疗剂对血流的损失最小化并提供受控递送至治疗部位。

公开(公告)号：US20120310210A1

公开(公告)日：2012-12-06

申请号：US13409843

申请日：2012-03-01

申请人： Carey V. Campbell ,  Robert L. Cleek ,  Theresa A. Holland ,  Thane L. Kranzler ,  Benjamin M. Trapp

发明人： Carey V. Campbell ,  Robert L. Cleek ,  Theresa A. Holland ,  Thane L. Kranzler ,  Benjamin M. Trapp

IPC分类号： A61M25/10 ,  A61M5/00

CPC分类号： A61M25/104 ,  A61F2/82 ,  A61F2250/0023 ,  A61F2250/0035 ,  A61F2250/0067 ,  A61L29/085 ,  A61L29/146 ,  A61L29/16 ,  A61L2300/416 ,  A61L2300/606 ,  A61M2025/09125 ,  A61M2025/1031 ,  A61M2025/105 ,  A61M2025/1075 ,  A61M2025/1081

摘要： The invention is directed to eluting medical devices that enable consistent “on-demand” delivery of therapeutic agents to a vessel. The medical device of the current invention comprises an expandable member, a hydrophilic coating comprising at least one therapeutic agent about the expandable member or structural layer and an outer sheath with a variably permeable microstructure. The design and methods disclosed herein ensures that therapeutic agent delivery occurs essentially only during expansion of the expandable member, minimizing coating and/or therapeutic agent loss to the bloodstream and providing controlled delivery to the treatment site.

摘要翻译： 本发明涉及洗脱能够使治疗剂按需递送至血管的医疗装置。 本发明的医疗装置包括可膨胀构件，亲水性涂层，其包括围绕可膨胀构件或结构层的至少一种治疗剂和具有可变可渗透微结构的外护套。 本文公开的设计和方法确保治疗剂递送基本上仅在可膨胀构件的膨胀期间发生，使涂覆和/或治疗剂对血流的损失最小化并提供受控递送至治疗部位。

公开(公告)号：US20130096606A1

公开(公告)日：2013-04-18

申请号：US13448277

申请日：2012-04-16

申请人： William C. Bruchman ,  Edward H. Cully ,  Cody L. Hartman ,  Joshua J. Lovekamp ,  Benjamin M. Trapp

发明人： William C. Bruchman ,  Edward H. Cully ,  Cody L. Hartman ,  Joshua J. Lovekamp ,  Benjamin M. Trapp

IPC分类号： A61F2/01

CPC分类号： A61F2/013 ,  A61F2002/016 ,  A61F2002/018 ,  A61F2210/0014 ,  A61F2230/0006 ,  A61F2230/0067 ,  A61F2230/0069 ,  A61F2230/008 ,  A61F2250/0023

摘要： According to one aspect of the disclosure, an embolic protection device is provided comprising an elongate element having a deflector at its distal end. The embolic protection device is generally configured to redirect and/or funnel embolic debris and permit at least a portion of the blood, no longer containing the redirected and/or funneled embolic debris, to perfuse the surrounding vasculature and/or tissue.

公开(公告)号：US09028444B2

公开(公告)日：2015-05-12

申请号：US13446915

申请日：2012-04-13

申请人： Carey V. Campbell ,  Nathan L. Friedman ,  Benjamin M. Trapp

发明人： Carey V. Campbell ,  Nathan L. Friedman ,  Benjamin M. Trapp

IPC分类号： A61M25/10

CPC分类号： A61F2/958 ,  A61F2/82 ,  A61F2210/0061 ,  A61F2250/0067 ,  A61F2250/0069 ,  A61M25/10 ,  A61M25/1018 ,  A61M2025/1068 ,  A61M2025/1084

摘要： The instant invention provides for a pivoting ring that can be used as a seal for an inflatable member. The pivoting ring seal offers a mechanical action which acts to tighten with increasing inflation and/or expansion of an inflatable member. As the inflatable member increases in pressure and/or size, one side of the ring is lifted and pivots around a fulcrum in the middle of the ring seal causing the opposite side of the ring seal to decrease in diameter. The pivot ring causes the opposite part of the seal to tighten about an inner member allowing for a higher-pressure seal. In addition to a higher pressure seal, the working length of the inflatable member can be adjusted by moving the ring along the length of the inflatable member.

摘要翻译： 本发明提供了可用作可膨胀构件的密封件的枢转环。 枢转环密封件提供机械作用，其作用为在可膨胀构件的增加的膨胀和/或膨胀的情况下紧固。 随着可膨胀构件的压力和/或尺寸增加，环的一侧被提升并且在环形密封件的中间围绕支点枢转，导致环形密封件的相对侧的直径减小。 枢轴环使得密封件的相对部分围绕允许较高压力密封的内部构件紧固。 除了更高的压力密封之外，可以通过沿着可充气构件的长度移动环来调节可膨胀构件的工作长度。

公开(公告)号：US20130116655A1

公开(公告)日：2013-05-09

申请号：US13645414

申请日：2012-10-04

申请人： John E. Bacino ,  Carey V. Campbell ,  Edward H. Cully ,  Jeffrey B. Duncan ,  Douglas S. Paget ,  John M. Squeri ,  Benjamin M. Trapp ,  Michael J. Vonesh ,  Edward E. Shaw

发明人： John E. Bacino ,  Carey V. Campbell ,  Edward H. Cully ,  Jeffrey B. Duncan ,  Douglas S. Paget ,  John M. Squeri ,  Benjamin M. Trapp ,  Michael J. Vonesh ,  Edward E. Shaw

IPC分类号： A61M25/10 ,  A61B17/3207

CPC分类号： A61B17/320725 ,  A61M25/1002 ,  A61M25/10184 ,  A61M25/1027 ,  A61M25/1029 ,  A61M25/104 ,  A61M2025/1031 ,  A61M2025/105 ,  A61M2025/1059 ,  A61M2025/1084 ,  A61M2025/1086 ,  Y10T29/49826 ,  Y10T29/49888

摘要： Various embodiments provide a device comprising a balloon disposed at least partially along a template, the template including an aperture, wherein the template has a substantially cylindrical portion that resists deformation in a radial direction, wherein the balloon expands radially during inflation, wherein a portion of the balloon at least partially protrudes about the aperture. Other embodiments are directed toward balloons having textured surfaces.

摘要翻译： 各种实施例提供了一种装置，其包括至少部分地沿着模板设置的气囊，模板包括孔，其中模板具有抵抗径向变形的大致圆柱形部分，其中气囊在充气期间径向膨胀，其中一部分 气球至少部分地围绕孔突出。 其他实施例针对具有纹理表面的气球。

公开(公告)号：US20120277718A1

公开(公告)日：2012-11-01

申请号：US13446915

申请日：2012-04-13

申请人： Carey V. Campbell ,  Nathan L. Friedman ,  Benjamin M. Trapp

发明人： Carey V. Campbell ,  Nathan L. Friedman ,  Benjamin M. Trapp

IPC分类号： A61M25/10

CPC分类号： A61F2/958 ,  A61F2/82 ,  A61F2210/0061 ,  A61F2250/0067 ,  A61F2250/0069 ,  A61M25/10 ,  A61M25/1018 ,  A61M2025/1068 ,  A61M2025/1084

摘要： The instant invention provides for a pivoting ring that can be used as a seal for an inflatable member. The pivoting ring seal offers a mechanical action which acts to tighten with increasing inflation and/or expansion of an inflatable member. As the inflatable member increases in pressure and/or size, one side of the ring is lifted and pivots around a fulcrum in the middle of the ring seal causing the opposite side of the ring seal to decrease in diameter. The pivot ring causes the opposite part of the seal to tighten about an inner member allowing for a higher-pressure seal. In addition to a higher pressure seal, the working length of the inflatable member can be adjusted by moving the ring along the length of the inflatable member.

摘要翻译： 本发明提供了可用作可膨胀构件的密封件的枢转环。 枢转环密封件提供机械作用，其作用为在可膨胀构件的增加的膨胀和/或膨胀的情况下紧固。 随着可膨胀构件的压力和/或尺寸增加，环的一侧被提升并且在环形密封件的中间围绕支点枢转，导致环形密封件的相对侧的直径减小。 枢轴环使得密封件的相对部分围绕允许较高压力密封的内部构件紧固。 除了更高的压力密封之外，可以通过沿着可充气构件的长度移动环来调节可膨胀构件的工作长度。

公开(公告)号：US07625337B2

公开(公告)日：2009-12-01

申请号：US11500836

申请日：2006-08-07

申请人： Carey V. Campbell ,  Edward H. Cully ,  Sherif Eskaros ,  George N. Foutrakis ,  James William Mann ,  Peter J. Roeber ,  Benjamin M. Trapp ,  Michael J. Vonesh

发明人： Carey V. Campbell ,  Edward H. Cully ,  Sherif Eskaros ,  George N. Foutrakis ,  James William Mann ,  Peter J. Roeber ,  Benjamin M. Trapp ,  Michael J. Vonesh

IPC分类号： A61B1/12 ,  A61M29/00

CPC分类号： A61M25/10 ,  A61F2/958 ,  A61M25/0023 ,  A61M25/0029 ,  A61M25/0032 ,  A61M25/0043 ,  A61M25/005 ,  A61M25/0051 ,  A61M25/0052 ,  A61M25/0053 ,  A61M25/1002 ,  A61M25/1011 ,  A61M2025/0034 ,  A61M2025/0035 ,  A61M2025/0063 ,  A61M2025/0183 ,  A61M2025/0188 ,  A61M2025/1056 ,  A61M2025/1081

摘要： Novel catheter constructions comprising thin covering or wrapping materials such as polymer films. A catheter provided with a guidewire catheter lumen having a thin covering that is easily punctured by a guidewire at virtually any desired point along the catheter length. The thin covering may be integral with the catheter shaft, or may be a separate component that covers only the portion of the catheter shaft immediately adjacent the outer portion of the guidewire lumen, or may be a thin tubular construct that surrounds the entire catheter shaft. Moreover, polymer film can be used in combination with one or more elements to produce novel catheter constructions.

摘要翻译： 新颖的导管结构包括薄的覆盖物或包裹材料如聚合物膜。 导管，其具有导线导管管腔，该导管管腔具有薄的覆盖层，其在导管长度的几乎任何所需点处被导丝容易地刺穿。 薄的覆盖物可以与导管轴成一体，或者可以是仅覆盖导管轴的紧邻导丝管腔的外部的部分的单独的部件，或者可以是围绕整个导管轴的薄的管状结构。 此外，聚合物膜可以与一种或多种元素组合使用以产生新的导管结构。

公开(公告)号：US10016579B2

公开(公告)日：2018-07-10

申请号：US13619806

申请日：2012-09-14

申请人： Carey V. Campbell ,  James L. Goepfrich ,  Brandon C. Hedberg ,  Benjamin M. Trapp

发明人： Carey V. Campbell ,  James L. Goepfrich ,  Brandon C. Hedberg ,  Benjamin M. Trapp

IPC分类号： A61M25/10 ,  A61F2/958

CPC分类号： A61M25/10 ,  A61F2/958 ,  A61M25/1029 ,  A61M25/104 ,  A61M2025/1031 ,  A61M2025/1075 ,  A61M2025/1081 ,  F04C2270/041

摘要： Embodiments are presented of a balloon assembly operable to provide a balloon diameter vs. balloon pressure profile generally depicting a balloon inflation sequence providing at least one intermediate inflated diameter and a final inflated diameter of a balloon such that the balloon attains the at least one intermediate diameter at a predetermined pressure, and attains the final diameter at a final predetermined pressure that is lower than a predetermined pressure of a last intermediate pressure.

公开(公告)号：US20090198219A1

公开(公告)日：2009-08-06

申请号：US12423267

申请日：2009-04-14

申请人： Carey V. Campbell ,  Edward H. Cully ,  Sherif Eskaros ,  George N. Foutrakis ,  James William Mann ,  Peter J. Roeber ,  Benjamin M. Trapp ,  Michael J. Vonesh

发明人： Carey V. Campbell ,  Edward H. Cully ,  Sherif Eskaros ,  George N. Foutrakis ,  James William Mann ,  Peter J. Roeber ,  Benjamin M. Trapp ,  Michael J. Vonesh

IPC分类号： A61M25/00

CPC分类号： A61M25/10 ,  A61F2/958 ,  A61M25/0023 ,  A61M25/0029 ,  A61M25/0032 ,  A61M25/0043 ,  A61M25/005 ,  A61M25/0051 ,  A61M25/0052 ,  A61M25/0053 ,  A61M25/1002 ,  A61M25/1011 ,  A61M2025/0034 ,  A61M2025/0035 ,  A61M2025/0063 ,  A61M2025/0183 ,  A61M2025/0188 ,  A61M2025/1056 ,  A61M2025/1081

摘要： Novel catheter constructions comprising thin covering or wrapping materials such as polymer films. A catheter provided with a guidewire catheter lumen having a thin covering that is easily punctured by a guidewire at virtually any desired point along the catheter length. The thin covering may be integral with the catheter shaft, or may be a separate component that covers only the portion of the catheter shaft immediately adjacent the outer portion of the guidewire lumen, or may be a thin tubular construct that surrounds the entire catheter shaft. Moreover, polymer film can be used in combination with one or more elements to produce novel catheter constructions.

摘要翻译： 新颖的导管结构包括薄的覆盖物或包裹材料如聚合物膜。 导管，其具有导线导管管腔，该导管管腔具有薄的覆盖层，其在导管长度的几乎任何所需点处被导丝容易地刺穿。 薄的覆盖物可以与导管轴成一体，或者可以是仅覆盖导管轴的紧邻导丝管腔的外部的部分的单独的部件，或者可以是围绕整个导管轴的薄的管状结构。 此外，聚合物膜可以与一种或多种元素组合使用以产生新的导管结构。