公开(公告)号：US20060195183A1

公开(公告)日：2006-08-31

申请号：US11357485

申请日：2006-02-18

申请人： Jose Navia ,  Jose Navia ,  Carlos Oberti

发明人： Jose Navia ,  Jose Navia ,  Carlos Oberti

IPC分类号： A61F2/24

CPC分类号： A61F2/2412 ,  A61F2/2409 ,  A61F2/2418 ,  A61F2/2445 ,  A61F2/2457 ,  A61F2002/8483 ,  A61F2220/0016 ,  A61F2220/0075 ,  A61F2230/0013

摘要： An apparatus and method for replacing a cardiac valve includes an expandable support member having oppositely disposed first and second ends, a main body portion extending between the ends, and a prosthetic valve within the main body portion. The main body portion has an annular shape for expanding into position in the annulus of the valve. The first and second ends include a plurality of upper and lower wing members movable from a collapsed condition into an extended condition for respectively engaging a first section of cardiac tissue surrounding the valve and for engaging a portion of the native valve leaflets to pin the leaflets back against the annulus. The second end further includes at least two strut members spaced apart from each other. A respective one of the strut members is attached to at least one commissural section of the prosthetic valve to prevent prolapse of the valve leaflets.

摘要翻译： 用于更换心脏瓣膜的装置和方法包括具有相对设置的第一和第二端部的可扩张支撑构件，在端部之间延伸的主体部分和主体部分内的假体阀。 主体部分具有用于扩展到阀的环形空间中的环形形状。 第一和第二端包括多个上部和下部翼构件，其可以从折叠状态移动到扩展状态，用于分别接合围绕阀的心脏组织的第一部分并且用于接合一部分天然瓣膜以将传单固定回 反对环。 第二端还包括彼此间隔开的至少两个支柱构件。 支柱构件中的相应一个附接到人工瓣膜的至少一个连合部分以防止瓣膜小叶脱垂。

公开(公告)号：US20060259135A1

公开(公告)日：2006-11-16

申请号：US11408756

申请日：2006-04-20

申请人： Jose Navia ,  Jose Navia ,  Carlos Oberti

发明人： Jose Navia ,  Jose Navia ,  Carlos Oberti

IPC分类号： A61F2/24

CPC分类号： A61F2/2409 ,  A61B2017/00243 ,  A61F2/2418 ,  A61F2/2436 ,  A61F2/2457 ,  A61F2210/009 ,  A61F2220/0008 ,  A61F2220/0016 ,  A61F2220/0075 ,  A61F2230/005 ,  A61F2230/0078

摘要： An apparatus for replacing a cardiac valve having at least two native valve leaflets includes an expandable support member with oppositely disposed first and second ends and a main body portion extending between the ends. The first and second ends respectively include a plurality of upper and lower wing members respectively having first and second magnetic components. The wing members extend from the main body portion and are spaced circumferentially thereabout. Secured within the main body portion is a prosthetic valve having at least two valve leaflets. The second end further includes at least two strut members spaced apart from each other and attached to at least one commissural section of the prosthetic valve. The magnetic components are magnetically attracted to one another so that, when the apparatus is placed in the valve annulus, the wing members are pulled toward one another to secure the prosthetic valve in the annulus.

摘要翻译： 用于更换具有至少两个天然瓣叶的心脏瓣膜的装置包括具有相对设置的第一和第二端的可扩张支撑构件和在两端之间延伸的主体部分。 第一和第二端分别包括分别具有第一和第二磁性部件的多个上翼和下翼部件。 翼构件从主体部分延伸并在其周围周向间隔开。 在主体部分内固定的是具有至少两个瓣叶的人工瓣膜。 第二端还包括彼此间隔开并连接到人工瓣膜的至少一个连合部分的至少两个支柱构件。 磁性部件彼此磁吸引，使得当该装置被放置在瓣膜环中时，翼部件被拉向彼此以将假性瓣膜固定在环空中。

公开(公告)号：US20070255389A1

公开(公告)日：2007-11-01

申请号：US11789827

申请日：2007-04-26

申请人： Carlos Oberti ,  Jose Navia

发明人： Carlos Oberti ,  Jose Navia

IPC分类号： A61F2/84 ,  A61F2/90

CPC分类号： A61F2/90 ,  A61F2/95 ,  A61F2002/821 ,  A61F2210/0004 ,  A61F2210/0076 ,  A61F2220/0008 ,  A61F2220/0016 ,  A61F2230/0054 ,  A61F2230/0078 ,  A61F2250/003 ,  A61F2250/0067 ,  A61N1/362

摘要： An apparatus for treating cardiovascular diseases includes an expandable support member having oppositely disposed proximal and distal end portions and a main body portion between the end portions for positioning in a blood vessel. The proximal end portion of the expandable support member includes a plurality of wing members that extend from the main body portion. Each of the wing members is for engaging at least a portion of an antrum of a cardiac chamber surrounding the blood vessel. At least a portion of the expandable support member is treated with at least one therapeutic agent for eluting into the blood vessel, the cardiac chamber, and/or cardiac tissue. The expandable support member is made of wire-mesh, and at least a portion of the expandable support member may be made of a bioabsorbable material.

摘要翻译： 用于治疗心血管疾病的装置包括具有相对设置的近端部分和远端部分的可扩张支撑构件和位于端部之间的主体部分，用于定位在血管中。 可扩展支撑构件的近端部分包括从主体部分延伸的多个翼构件。 每个翼构件用于接合围绕血管的心室的窦的至少一部分。 至少一部分可膨胀支撑构件用至少一种用于洗脱到血管，心脏腔和/或心脏组织中的治疗剂进行治疗。 可膨胀支撑构件由金属丝网制成，并且可膨胀支撑构件的至少一部分可以由生物可吸收材料制成。

公开(公告)号：US20050101902A1

公开(公告)日：2005-05-12

申请号：US10938048

申请日：2004-09-10

申请人： Jose Navia ,  Jose Navia ,  Jorge Jordana

发明人： Jose Navia ,  Jose Navia ,  Jorge Jordana

IPC分类号： A61F2/86 ,  A61M5/00 ,  A61N1/362

CPC分类号： A61B17/12172 ,  A61B17/12022 ,  A61B17/12036 ,  A61B17/12136 ,  A61B2017/1139 ,  A61F2/86 ,  A61M1/3613

摘要： An apparatus for automatically retroperfusing a coronary vein includes an intraluminal cannula having a main body portion extending between a proximal end portion and a distal end portion. The proximal end portion is for connecting to an artery outside of the pericardium to automatically supply oxygenated blood from the artery for retroperfusion. The main body portion and the distal end portion are insertable through a vein that is fluidly connected with the coronary vein and into the coronary vein. An expandable stent is attached to the distal end portion for expanding radially into engagement with the interior wall of the coronary vein to secure the distal end portion at a desired location within the coronary vein. Occluding structure for at least partially occluding the coronary vein is provided at the distal end to decrease the back-flow of blood into the right atrium during retroperfusion. The cannula includes passages that allow a limited amount of blood to bypass the occluding structure.

摘要翻译： 用于自动回灌冠状静脉的装置包括管腔内插管，其具有在近端部分和远端部分之间延伸的主体部分。 近端部分用于连接到心包外的动脉，以自动地从动脉供应氧合血液用于后路灌注。 主体部分和远端部分可通过与冠状静脉流体连接并进入冠状静脉的静脉插入。 可扩张支架附接到远端部分，用于径向扩张以与冠状静脉的内壁接合，以将远端部分固定在冠状静脉内的期望位置。 在远端提供用于至少部分阻塞冠状静脉的封闭结构，以减少后期灌注期间血液向右心房的逆流。 套管包括允许有限量的血液绕过闭塞结构的通道。

公开(公告)号：US20070233239A1

公开(公告)日：2007-10-04

申请号：US11586828

申请日：2006-10-26

申请人： Jose Navia ,  Jose Navia ,  Ghassan Kassab

发明人： Jose Navia ,  Jose Navia ,  Ghassan Kassab

IPC分类号： A61F2/24

CPC分类号： A61F2/2445 ,  A61F2/2466 ,  A61F2210/009 ,  A61F2250/0001 ,  A61F2250/0004

摘要： An apparatus for modifying the annulus of a cardiac valve to reduce regurgitation of blood flow through the cardiac valve includes a first annuloplasty ring having a first diameter and being disposed about a first aspect of the annulus of the cardiac valve. The apparatus also includes an elongate flexible body having proximal and distal end portions and being insertable into the first annuloplasty ring. The elongate flexible body has an adjustable mechanism for selectively adjusting the elongate flexible body from a first relaxed configuration to a second tensioned configuration. The first annuloplasty ring is adaptable to obtain a second smaller diameter and to cause the annulus of the cardiac valve to be modified and reduce regurgitation of blood flow through the cardiac valve when the elongate flexible body obtains the second tensioned configuration.

摘要翻译： 用于改变心脏瓣膜的环以减少通过心脏瓣膜的血流反流的装置包括具有第一直径的第一瓣环成形术环，并且围绕心脏瓣膜的环的第一方面设置。 该装置还包括具有近端部分和远端部分并且可插入第一瓣环成形术环的细长柔性体。 细长柔性体具有可调节机构，用于将细长柔性体从第一松弛构型选择性地调节到第二张紧构型。 第一瓣环成形术环适用于获得第二较小的直径，并且当细长的柔性体获得第二张紧构造时，使得心脏瓣膜的环被修改并且减少通过心脏瓣膜的血流的反流。

公开(公告)号：US20060195060A1

公开(公告)日：2006-08-31

申请号：US11325816

申请日：2006-01-05

申请人： Jose Navia ,  Jose Navia ,  Jorge Jordana ,  Ji-Feng Chen

发明人： Jose Navia ,  Jose Navia ,  Jorge Jordana ,  Ji-Feng Chen

IPC分类号： A61M29/00

CPC分类号： A61M1/3653 ,  A61F2/01 ,  A61F2/90 ,  A61F2220/0008 ,  A61M1/3613 ,  A61M1/3659

摘要： An apparatus and method for automatically retroperfusing a coronary vein. The apparatus includes an intraluminal graft having a tubular body extending between a proximal end and a distal end. The proximal end is for fluidly connecting to an artery to automatically supply retrograde blood for retroperfusion. The tubular body and the distal end are extendable into a vein that is fluidly connected with the coronary vein to be retroperfused. The distal end includes an expandable stent for securing the distal end in the coronary vein.

公开(公告)号：US20060195182A1

公开(公告)日：2006-08-31

申请号：US11348172

申请日：2006-02-06

申请人： Jose Navia ,  Jose Navia ,  Jorge Jordana

发明人： Jose Navia ,  Jose Navia ,  Jorge Jordana

IPC分类号： A61F2/24

CPC分类号： A61F2/2412 ,  A61F2/2457 ,  A61F2220/0075

摘要： A stentless bioprosthetic valve includes at least one piece of biocompatible material comprising a bi-leaflet conduit. The conduit has a distal end, a proximal end defining a first annulus for suturing to the valve annulus of a heart, and leaflets extending between the proximal and distal ends. The distal end defines a second annulus having a profile substantially similar to a first annulus profile, at which the leaflets terminate. The second annulus is sutured to free edges of the leaflets of the native mitral valve that remain intact following resection of the native mitral valve. Therefore, the native chordae tendineae continue to provide prolapse prevention and left ventricular muscle support functions in addition to maintaining continuity between the valve annulus and the papillary muscles. The second annulus is spaced from the papillary muscles. A method for replacing the native mitral valve with a stentless bioprosthetic valve is also provided.

摘要翻译： 无支架生物假肢瓣膜包括至少一片包含双叶导管的生物相容性材料。 导管具有远端，限定用于缝合到心脏的瓣膜环的第一环的近端，以及在近端和远端之间延伸的小叶。 远端限定具有基本上类似于第一环形轮廓的轮廓的第二环形，叶片终止于该第一环状轮廓。 将第二个环缝合到自然二尖瓣的小叶的自由边缘，在切除天然二尖瓣后保持完整。 因此，除了保持瓣膜环和乳头肌之间的连续性之外，天然腱索腱还继续提供脱垂预防和左心室肌支撑功能。 第二个环与乳头肌间隔开。 还提供了用无支架生物假体瓣膜替代原生二尖瓣的方法。

公开(公告)号：US20070038296A1

公开(公告)日：2007-02-15

申请号：US11486584

申请日：2006-07-14

申请人： Jose Navia ,  Jose Navia

发明人： Jose Navia ,  Jose Navia

IPC分类号： A61F2/24

CPC分类号： A61F2/2448 ,  A61F2/2466 ,  A61F2210/009 ,  A61F2250/006

摘要： An apparatus for remodeling the annulus of a cardiac valve includes a first elongate flexible member having a distal end portion and a proximal end portion interconnected by a main body portion. The distal end portion is steerable from the proximal end portion and advanceable to one side of the cardiac valve annulus via a percutaneous approach. The distal end portion includes a terminal end and a connecting section spaced apart by a predetermined length. The connecting section has a structure for disconnecting from the main body portion, in addition to a structure for interconnecting with the terminal end to form a ring of a predetermined shape adjacent the one side of the cardiac valve annulus. The distal end portion further includes a mechanism for attaching to the cardiac valve annulus so that, when the ring is formed, the distal end portion contracts and thereby remodels the annulus of the cardiac valve. The apparatus can also include a second elongate flexible member for positioning on the opposite side of the native valve annulus and which may be magnetically attracted to the first flexible member in order to attach the apparatus to the valve annulus.

摘要翻译： 用于重建心脏瓣膜环的装置包括具有通过主体部分互连的远端部分和近端部分的第一细长柔性构件。 远端部分可从近端部分转向并通过经皮方式前进到心脏瓣膜环的一侧。 前端部分包括一个末端和一个间隔开预定长度的连接部分。 连接部具有用于与主体部分断开的结构，除了用于与终端相互连接以形成邻近心脏瓣膜环的一侧的预定形状的环的结构。 远端部还包括用于附接到心脏瓣膜环的机构，使得当环形成时，远端部分收缩并从而重建心脏瓣膜的环。 该装置还可以包括第二细长柔性构件，用于定位在天然瓣膜环的相对侧上，并且可以被磁性地吸引到第一柔性构件，以将装置附接到瓣膜环。

公开(公告)号：US20100022946A1

公开(公告)日：2010-01-28

申请号：US12521629

申请日：2008-01-22

申请人： Ghassan S. Kassab ,  Jose Navia

发明人： Ghassan S. Kassab ,  Jose Navia

IPC分类号： A61B17/03 ,  A61M25/06 ,  A61M1/00

CPC分类号： A61B17/12022 ,  A61B17/00491 ,  A61B17/12118 ,  A61B17/12186 ,  A61B2017/00876 ,  A61B2017/1205

摘要： The disclosure of the present application includes assemblies, systems, and methods for preventing endoleak and migration. In an embodiment of an assembly for delivering a magnetic glue-like substance, the assembly comprises a catheter defining a catheter, a needle positioned within the catheter, and a needle wire, whereby a magnetic glue-like substance may be injected through a needle wire to a target site.

摘要翻译： 本申请的公开内容包括用于防止内漏和迁移的组件，系统和方法。 在用于递送磁性胶状物质的组件的实施例中，组件包括限定导管，定位在导管内的针和针线的导管，由此磁性胶状物质可以通过针线 到目标站点。

公开(公告)号：US20050187617A1

公开(公告)日：2005-08-25

申请号：US11037499

申请日：2005-01-18

申请人： Jose Navia

发明人： Jose Navia

IPC分类号： A61F2/24

CPC分类号： A61F2/2412 ,  Y10S623/904

摘要： A method and apparatus for replacing both the native mitral valve and the native aortic valve in a heart with a stentless bioprosthetic graft is provided. The bioprosthetic graft comprises a harvested homograft that includes a mitral valve portion and an aortic valve portion, and an extension portion made of a biocompatible material. The extension portion is sutured to the homograft and is for suturing to the left atrial wall of the heart to close an incision in the left atrial wall following implantation of the mitral valve portion and the aortic valve portion of the homograft.

摘要翻译： 提供了用无置换生物假体移植物替代心脏中的天然二尖瓣和天然主动脉瓣的方法和装置。 生物假体移植物包括收获的同种移植物，其包括二尖瓣部分和主动脉瓣部分，以及由生物相容性材料制成的延伸部分。 将延伸部分缝合到同种移植物，并用于缝合到心脏的左心房壁，以在植入二尖瓣部分和同种移植物的主动脉瓣部分之后闭合左心房壁中的切口。