公开(公告)号：US20080260804A1

公开(公告)日：2008-10-23

申请号：US12214321

申请日：2008-06-18

申请人： Carol Ann Morris ,  Manal M. Gabriel ,  Yongxing Qiu ,  Lynn Cook Winterton ,  John Martin Lally ,  Marcia Kay Ash ,  Fiona Patricia Carney ,  Courtney Flem Morgan

发明人： Carol Ann Morris ,  Manal M. Gabriel ,  Yongxing Qiu ,  Lynn Cook Winterton ,  John Martin Lally ,  Marcia Kay Ash ,  Fiona Patricia Carney ,  Courtney Flem Morgan

IPC分类号： A01N25/34 ,  A01N33/12 ,  A61K38/40 ,  G01N19/02

CPC分类号： G02B1/043 ,  A61L27/34 ,  A61L31/10

摘要： The present invention provides a medical device, preferably a contact lens, which comprises an antimicrobial coating including at least one layer of polyquat of formula (I) or (II). The antimicrobial coating on the medical device of the invention has a high antimicrobial efficacy against microorganisms including Gram-positive and Gram-negative bacterial, a low toxicity, low coefficient of friction, and increased hydrophilicity while maintaining the desired bulk properties such as oxygen permeability and ion permeability of lens material. Such lenses are useful as extended-wear contact lenses. In addition, the invention provides a method for making a medical device, preferably a contact lens, having an antimicrobial coating thereon.

摘要翻译： 本发明提供一种医疗装置，优选隐形眼镜，其包括抗微生物涂层，其包含至少一层式（I）或（II）的聚四氢叶酸。 本发明的医疗装置上的抗微生物涂层对微生物具有高抗微生物效果，包括革兰氏阳性和革兰氏阴性细菌，低毒性，低摩擦系数和增加的亲水性，同时保持所需的体积特性如氧气渗透性和 透镜材料的离子透过率。 这种透镜可用作延长佩戴的隐形眼镜。 此外，本发明提供了制造其上具有抗微生物涂层的医疗装置，优选隐形眼镜的方法。

公开(公告)号：US07402318B2

公开(公告)日：2008-07-22

申请号：US10287091

申请日：2002-11-04

申请人： Carol Ann Morris ,  Manal M. Gabriel ,  Yongxing Qiu ,  Lynn Cook Winterton ,  John Martin Lally ,  Marcia Kay Ash ,  Fiona Patricia Carney ,  Courtney Flem Morgan

发明人： Carol Ann Morris ,  Manal M. Gabriel ,  Yongxing Qiu ,  Lynn Cook Winterton ,  John Martin Lally ,  Marcia Kay Ash ,  Fiona Patricia Carney ,  Courtney Flem Morgan

IPC分类号： A61F13/00

CPC分类号： G02B1/043 ,  A61L27/34 ,  A61L31/10

摘要： The present invention provides a medical device, preferably a contact lens, which comprises an antimicrobial coating including at least one layer of polyquat of formula (I) or (II). The antimicrobial coating on the medical device of the invention has a high antimicrobial efficacy against microorganisms including Gram-positive and Gram-negative bacterial, a low toxicity, low coefficient of friction, and increased hydrophilicity while maintaining the desired bulk properties such as oxygen permeability and ion permeability of lens material. Such lenses are useful as extended-wear contact lenses. In addition, the invention provides a method for making a medical device, preferably a contact lens, having an antimicrobial coating thereon.

公开(公告)号：US09248614B2

公开(公告)日：2016-02-02

申请号：US11147594

申请日：2005-06-08

申请人： John Christopher Phelan ,  Michael Hugh Quinn ,  Rafael Victor Andino ,  Marcia Kay Ash ,  Allen Douglas Gilliard ,  Tomasz Jankiewicz ,  Courtney Flem Morgan ,  Joseph Michael Lindacher ,  Corneliu Daniel Niculas

发明人： John Christopher Phelan ,  Michael Hugh Quinn ,  Rafael Victor Andino ,  Marcia Kay Ash ,  Allen Douglas Gilliard ,  Tomasz Jankiewicz ,  Courtney Flem Morgan ,  Joseph Michael Lindacher ,  Corneliu Daniel Niculas

IPC分类号： B29D11/00 ,  B29C47/00 ,  B29C69/00

CPC分类号： B29D11/00038 ,  B29C47/0021 ,  B29C47/0038 ,  B29C47/0057 ,  B29C69/001 ,  B29D11/00076 ,  B29D11/00932

摘要： The present invention provides methods for lathing at room temperature a silicone hydrogel material, in particular silicone hydrogel material having a high oxygen permeability and made of a polymerizable composition containing a relative large amount of oxyperm component, into contact lenses.

公开(公告)号：US07671156B2

公开(公告)日：2010-03-02

申请号：US11500757

申请日：2006-08-08

申请人： John Christopher Phelan ,  Angelika Maria Domschke ,  Marcia Kay Ash

发明人： John Christopher Phelan ,  Angelika Maria Domschke ,  Marcia Kay Ash

IPC分类号： C08F30/08

CPC分类号： G02B1/043 ,  C08L51/085

摘要： The present invention provides silicone hydrogel materials having relatively high oxygen permeability and a relatively low modulus. The relatively-low modulus is achieved by adding a chain transfer agent into a polymerizable fluid composition in an amount sufficient to provide to the resultant silicone hydrogel material with a reduced modulus. In addition, the invention provides silicone hydrogel contact lenses comprising a silicone hydrogel material of the invention, a method for making a silicone hydrogel material of the invention, and a method for making a silicone hydrogel contact lens of the invention.

摘要翻译： 本发明提供了具有相对较高的氧气渗透性和较低模量的硅酮水凝胶材料。 相对低的模量通过将链转移剂加入到可聚合流体组合物中来实现，其量足以提供具有降低的模量的所得硅酮水凝胶材料。 此外，本发明提供了包含本发明的硅氧烷水凝胶材料的硅酮水凝胶隐形眼镜，本发明的硅氧水凝胶材料的制备方法和本发明的硅氧水凝胶隐形眼镜的制备方法。