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    Diffusion-controllable coatings on medical device
    3.
    发明授权
    Diffusion-controllable coatings on medical device 有权
    医疗器械上的扩散可控涂层

    公开(公告)号：US06827966B2

    公开(公告)日：2004-12-07

    申请号：US10153063

    申请日：2002-05-22

    申请人： Yongxing Qiu ,  Fiona Patricia Carney ,  Nichola Kotov ,  John Martin Lally ,  Carol Ann Morris ,  Lynn Cook Winterton

    发明人： Yongxing Qiu ,  Fiona Patricia Carney ,  Nichola Kotov ,  John Martin Lally ,  Carol Ann Morris ,  Lynn Cook Winterton

    IPC分类号： B05D300

    CPC分类号： A61L27/34 ,  A61L27/306 ,  A61L31/088 ,  A61L31/10 ,  G02B1/043

    摘要： The present invention provides a method for forming on a medical device, preferably an ophthalmic lens, more preferably a contact lens, a diffusion-controllable coating capable of controlling the out-diffusion or release of guest materials from the medical device. The method of the invention comprises: (1) applying one layer of clay and optionally one or more layers of polyionic materials onto the medical device; or (2) applying alternatively a layer of a first polyionic material and a layer of a second polyionic material having charges opposite of the charges of the first polyionic material onto the medical device and releasing the coated medical device into a releasing medium having a composition capable of imparting a desired permeability to the diffusion-controllable coating on the medical device.

    摘要翻译： 本发明提供了一种用于在医疗装置上形成的方法，优选为眼科镜片，更优选隐形眼镜，能够控制来自医疗装置的客体材料的扩散或释放的扩散控制涂层。 本发明的方法包括：（1）将一层粘土和任选的一层或多层聚离子材料施加到医疗装置上; 或（2）交替地将第一聚离子材料层和具有与第一聚离子材料的电荷相反的电荷的第二聚离子材料层施加到医疗装置上，并将涂覆的医疗装置释放到具有能够 对所述医疗装置上的扩散可控涂层施加期望的渗透性。

    Medical devices having antimicrobial coatings thereon
    4.
    发明授权
    Medical devices having antimicrobial coatings thereon 有权
    在其上具有抗微生物涂层的医疗装置

    公开(公告)号：US08172395B2

    公开(公告)日：2012-05-08

    申请号：US10722256

    申请日：2003-11-25

    申请人： Fiona Patricia Carney ,  Manal M. Gabriel ,  Carol Ann Morris ,  John Martin Lally

    发明人： Fiona Patricia Carney ,  Manal M. Gabriel ,  Carol Ann Morris ,  John Martin Lally

    IPC分类号： G02C7/02

    CPC分类号： A61L27/54 ,  A61L27/34 ,  A61L29/085 ,  A61L29/16 ,  A61L31/10 ,  A61L31/16 ,  A61L2300/25 ,  A61L2300/404 ,  A61L2300/608

    摘要： The present invention provides a medical device, preferably a contact lens, which comprises an antimicrobial LbL coating containing one or more antimicrobial pepetides. The antimicrobial coating of the invention can impart to the medical an increased surface hydrophilicity and a relatively high antimicrobial activity coupled with low cytotoxicity. The antimicrobial coating of the invention has a minimal adverse effects on the desirable bulk properties of a contact lens, such as oxygen permeability, ion permeability, and optical properties. An antimicrobial coating of the present invention may find particular use in extended-wear contact lenses. In addition, the invention provides a method for making a medical device, preferably a contact lens, having an antimicrobial LbL coating thereon.

    摘要翻译： 本发明提供一种医疗装置，优选隐形眼镜，其包括含有一种或多种抗微生物肽的抗微生物LbL涂层。 本发明的抗微生物涂层可以赋予医学更高的表面亲水性和相对高的抗微生物活性以及低的细胞毒性。 本发明的抗微生物涂层对隐形眼镜的期望体积特性具有最小的不利影响，例如透氧性，离子渗透性和光学性质。 本发明的抗微生物涂层可以在延长佩戴的隐形眼镜中发现特别有用。 此外，本发明提供了制造其上具有抗微生物LbL涂层的医疗装置，优选隐形眼镜的方法。

    Diffusion-controllable coatings on medical device
    5.
    发明授权
    Diffusion-controllable coatings on medical device 有权
    医疗器械上的扩散可控涂层

    公开(公告)号：US07666461B2

    公开(公告)日：2010-02-23

    申请号：US10969280

    申请日：2004-10-20

    申请人： Yongxing Qiu ,  Fiona Patricia Carney ,  Nichola Kotov ,  John Martin Lally ,  Carol Ann Morris

    发明人： Yongxing Qiu ,  Fiona Patricia Carney ,  Nichola Kotov ,  John Martin Lally ,  Carol Ann Morris

    IPC分类号： B05D3/00 ,  G02C7/04 ,  A61F2/14

    CPC分类号： A61L27/34 ,  A61L27/306 ,  A61L31/088 ,  A61L31/10 ,  G02B1/043

    摘要： The present invention provides a method for forming on a medical device, preferably an ophthalmic lens, more preferably a contact lens, a diffusion-controllable coating capable of controlling the out-diffusion or release of guest materials from the medical device. The method of the invention comprises: (1) applying one layer of clay and optionally one or more layers of polyionic materials onto the medical device; or (2) applying alternatively a layer of a first polyionic material and a layer of a second polyionic material having charges opposite of the charges of the first polyionic material onto the medical device and releasing the coated medical device into a releasing medium having a composition capable of imparting a desired permeability to the diffusion-controllable coating on the medical device.

    摘要翻译： 本发明提供了一种用于在医疗装置上形成的方法，优选为眼科镜片，更优选隐形眼镜，能够控制来自医疗装置的客体材料的扩散或释放的扩散控制涂层。 本发明的方法包括：（1）将一层粘土和任选的一层或多层聚离子材料施加到医疗装置上; 或（2）交替地将第一聚离子材料层和具有与第一聚离子材料的电荷相反的电荷的第二聚离子材料层施加到医疗装置上，并将涂覆的医疗装置释放到具有能够 对所述医疗装置上的扩散可控涂层施加期望的渗透性。

    Kits for assays of rapid screening of diabetes
    7.
    发明授权
    Kits for assays of rapid screening of diabetes 失效
    快速筛查糖尿病检测试剂盒

    公开(公告)号：US07429462B2

    公开(公告)日：2008-09-30

    申请号：US11706809

    申请日：2007-02-15

    申请人： Carol Ann Morris ,  Fiona Patricia Carney ,  Jennifer Dawn Lane

    发明人： Carol Ann Morris ,  Fiona Patricia Carney ,  Jennifer Dawn Lane

    IPC分类号： C12Q1/54

    CPC分类号： G01N33/6893 ,  G01N33/66 ,  G01N2800/042

    摘要： The invention provides an in vivo screening assay and an in vitro screening assay for rapid screening of diabetes. A method of the invention includes determining a first glucose concentration in an ocular fluid of a patient; administering orally a load of carbohydrate to the patient; determining a second glucose concentration in an ocular fluid of the patient at a period of time of less than 50 minutes after orally administering of the load of carbohydrate; comparing the second glucose concentration with the first glucose concentration to determine if the patient is likely to be a diabetic. The method of the invention is performed by using a kit of the invention. The kit comprises: (1) a glucose-sensing ophthalmic device and instructions for using the glucose-sensing ophthalmic device to screen for diabetes; or (2) two or more tear-collecting devices, and a testing agent composition which specifically reacts with glucose to form a detectable signal. The glucose-sensing ophthalmic device comprises a testing agent composition which specifically and reversibly interacts with glucose to form a detectable optical signal which changes in a concentration-dependent manner.

    摘要翻译： 本发明提供体内筛选测定和用于快速筛选糖尿病的体外筛选测定。 本发明的方法包括确定患者眼部流体中的第一葡萄糖浓度; 向患者口服负荷的碳水化合物; 在口服施用碳水化合物之后，在小于50分钟的时间段确定患者眼液中的第二葡萄糖浓度; 将第二葡萄糖浓度与第一葡萄糖浓度进行比较以确定患者是否可能是糖尿病。 本发明的方法通过使用本发明的试剂盒进行。 该试剂盒包括：（1）葡萄糖感测眼科装置和使用葡萄糖感测眼科装置筛查糖尿病的说明书; 或（2）两种或更多种泪液收集装置，以及与葡萄糖特异性反应以形成可检测信号的检测剂组合物。 葡萄糖感测眼科装置包括与葡萄糖特异性和可逆地相互作用以形成以浓度依赖性方式变化的可检测光学信号的测试剂组合物。

    Method for monitoring fertility by measuring the concentration of hormones in tears
    9.
    发明授权
    Method for monitoring fertility by measuring the concentration of hormones in tears 有权
    通过测量眼泪中激素浓度来监测生育力的方法

    公开(公告)号：US09050050B2

    公开(公告)日：2015-06-09

    申请号：US11787681

    申请日：2007-04-17

    申请人： Fiona Patricia Carney ,  Carol Ann Morris

    发明人： Fiona Patricia Carney ,  Carol Ann Morris

    IPC分类号： A61B5/00 ,  A61B5/145 ,  A61B10/00 ,  A61B5/1455

    CPC分类号： A61B5/42 ,  A61B5/145 ,  A61B5/14532 ,  A61B5/14546 ,  A61B5/1455 ,  A61B5/4306 ,  A61B10/0012 ,  A61B10/0045 ,  A61B2010/0067

    摘要： The invention provides methods and kits for monitoring the status of women's health, including HRT monitoring and determination or diagnosis of ovulation, contraception, pregnancy, menopause, polycystic ovarian disease, and female sexual dysfunction. The method comprises the steps of: (a) collecting a tear fluid from a female human; (b) determining the tear concentration of at least one hormone of relevance to female fertility, sexual differentiation or sexual dysfunction in a female human, wherein the tear concentration is diagnostics of the status of women's health.

    摘要翻译： 本发明提供了监测妇女健康状况的方法和工具，包括HRT监测和排卵，避孕，怀孕，绝经，多囊卵巢疾病和女性性功能障碍的确定或诊断。 该方法包括以下步骤：（a）从女性人体收集泪液; （b）确定与女性生殖力，性别分化或性功能障碍相关的至少一种激素的泪液浓度，其中泪液浓度是对妇女健康状况的诊断。