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    Layered Nanoparticles for Sustained Release of Small Molecules
    1.
    发明申请
    Layered Nanoparticles for Sustained Release of Small Molecules 审中-公开
    分层纳米粒子用于持续释放小分子

    公开(公告)号：US20090061006A1

    公开(公告)日：2009-03-05

    申请号：US12294359

    申请日：2007-03-28

    申请人： Carola Leuschner ,  Yuri M. Lvov ,  Challa S.S.R. Kumar

    发明人： Carola Leuschner ,  Yuri M. Lvov ,  Challa S.S.R. Kumar

    IPC分类号： A61K9/14 ,  A61K38/17 ,  A61K38/10

    CPC分类号： A61K9/5115 ,  A61K9/5161 ,  A61K47/62

    摘要： Nanoparticle compositions and methods are disclosed for the sustained release of small molecules, such as pharmaceutical compounds in vivo, for example ligand-lytic peptide conjugates. The construction of the nanoparticles helps to prevent self-aggregation of the molecules, and the consequent loss of effectiveness. The system employs layer-by-layer self-assembly of biocompatible polyelectrolyte layers, and layers of charged small molecules such as drug molecules, to form a multilayer nanoparticle in which the drug or other small molecule itself acts as one of the alternating charged layers in the multilayer assembly. The small molecules can then be released over time in a sustained manner. The LbL nano-assemblies can specifically target cancers, metastases, or other diseased tissues, while minimizing side effects.

    摘要翻译： 公开了纳米颗粒组合物和方法用于持续释放小分子，例如体内的药物化合物，例如配体 - 溶解肽缀合物。 纳米颗粒的构建有助于防止分子的自聚集，从而导致有效性的丧失。 该系统采用生物相容性聚电解质层和电荷小分子层（例如药物分子）的逐层自组装形成多层纳米颗粒，其中药物或其它小分子本身作为交替充电层之一 多层组件。 然后可以持续的方式随时间释放小分子。 LbL纳米组件可以特异性靶向癌症，转移瘤或其他患病组织，同时尽量减少副作用。

    In Vivo Imaging and Therapy with Magnetic Nanoparticle Conjugates
    2.
    发明申请
    In Vivo Imaging and Therapy with Magnetic Nanoparticle Conjugates 审中-公开
    用磁性纳米粒子缀合物进行体内成像和治疗

    公开(公告)号：US20090169478A1

    公开(公告)日：2009-07-02

    申请号：US11997370

    申请日：2006-08-04

    申请人： Carola Leuschner ,  Challa S.S.R. Kumar ,  William Hansel ,  Josef Hormes

    发明人： Carola Leuschner ,  Challa S.S.R. Kumar ,  William Hansel ,  Josef Hormes

    IPC分类号： A61K49/18 ,  B32B1/00 ,  A61K49/04 ,  A61K49/22 ,  A61K9/14 ,  A61K39/395 ,  A61P35/00

    CPC分类号： A61K49/1866 ,  B82Y5/00 ,  Y10T428/2982

    摘要： A non-invasive in vivo technique is disclosed, useful for example in detecting cancers and micrometastases. The technique may be used to selectively deliver drugs to target cells such as tumors, metastases, micrometastases, and individual malignant cells. Ligands with specificity for a target cell receptor, and optionally drug molecules as well, are covalently bound to magnetic nanoparticles, either directly or through a spacer molecule. The ligand precludes the need for a separate coating layer. For example, human breast cancer cells express receptors both for luteinizing hormone/chorionic gonadotropin (LH/CG), and for luteinizing hormone releasing hormone (LHRH). These cells can be specifically targeted by iron oxide nanoparticles covalently linked to LH/CG or LHRH. The nanoparticles are incorporated into the cancer cells through receptor-mediated endocytosis. The specific accumulation in targeted cancer cells enhances resolution for imaging, therapy, or both. The ligand may, for example, be a hormone, receptor, or antibody, or a fragment thereof.

    摘要翻译： 公开了非侵入性体内技术，其可用于例如检测癌症和微转移。 该技术可用于选择性地向靶细胞递送药物，例如肿瘤，转移瘤，微转移和个体恶性细胞。 对靶细胞受体具有特异性的配体以及任选的药物分子也可直接或通过间隔分子与磁性纳米粒子共价结合。 配体排除了对单独涂层的需要。 例如，人乳腺癌细胞表达促黄体激素/绒毛膜促性腺激素（LH / CG）和黄体生成激素释放激素（LHRH）的受体。 这些细胞可以与共价连接到LH / CG或LHRH的氧化铁纳米粒子特异性靶向。 通过受体介导的胞吞作用将纳米颗粒掺入癌细胞。 靶向癌细胞中的特异性积累增强了成像，治疗或两者的分辨率。 配体可以是例如激素，受体或抗体或其片段。