Highly compactable and durable direct compression excipients and excipient systems
    5.
    发明授权
    Highly compactable and durable direct compression excipients and excipient systems 有权
    高度紧凑和耐用的直接压缩赋形剂和赋形剂系统

    公开(公告)号:US08617588B2

    公开(公告)日:2013-12-31

    申请号:US12661016

    申请日:2010-03-09

    IPC分类号: A61F13/00 A61K9/70 A61K9/20

    摘要: The present invention relates to solid dispersions including, but not limited to, co-processed carbohydrates with different solubilities and concentrations, which have a microcrystalline plate structure. The solid dispersions, excipient systems and formulations of the present invention are highly compactable and durable and when compressed into solid dosage forms demonstrate uniform densification, low friability at low pressures, and/or relatively constant low disintegration times at various hardnesses. The solid dosage forms of the present invention demonstrate superior organoleptics, disintegration, and/or robustness.

    摘要翻译: 本发明涉及固体分散体,包括但不限于具有不同溶解度和浓度的共加工碳水化合物,其具有微晶板结构。 本发明的固体分散体,赋形剂体系和制剂是高度可压缩和耐久的,并且当被压缩成固体剂型时,显示均匀的致密化,低压力下的低脆性和/或在各种硬度下相对恒定的低崩解时间。 本发明的固体剂型表现出优异的感官,崩解和/或鲁棒性。