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公开(公告)号：US20180008458A1
公开(公告)日：2018-01-11
申请号：US15539565
申请日：2015-04-30
Applicant: Cell Cure Neurosciences Ltd.
Inventor： Eyal Banin , Benjamin Eithan Reubinoff , Osnat Bohana-Kashtan , Nir Netzer , Charles Sherard Irving
CPC classification number: A61F9/0008 , A61F9/00727 , A61K35/30 , A61K38/1709 , A61K2035/124 , C12N5/0621
Abstract: A method of treating a subject with dry-form age-related macular degeneration (AMD) is disclosed. The method comprises administering into the subretina of the subject a therapeutically effective amount of a pharmaceutical composition comprising human RPE cells, wherein at least 95% of the cells thereof co-express premelanosome protein (PMEL17) and cellular retinaldehyde binding protein (CRALBP), wherein the trans-epithelial electrical resistance of the cells is greater than 100 ohms to the subject, thereby treating the subject.
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Patent Agency Ranking
公开(公告)号：US09658216B2
公开(公告)日：2017-05-23
申请号：US14375195
申请日：2013-01-29
Inventor： Benjamin Eithan Reubinoff , Nurit Yachimovich-Cohen , Limor Matzrafi
CPC classification number: G01N33/56966 , C12N5/0621 , C12N2501/15 , C12N2501/16 , C12N2506/45 , C12N2509/00 , G01N21/6486 , G01N33/52 , G01N33/582 , G01N2021/4704 , G01N2333/46
Abstract: A method of selecting retinal pigmented epithelial (RPE) cells from a mixed population of cells is disclosed. The method comprises: (a) analyzing the cells of the mixed population of cells for at least one of the following parameters: (i) cells which autofluorescence above a predetermined threshold; (ii) cells which express CD81 above a predetermined threshold; and (iii) cells which scatter light perpendicular to a laser beam above a predetermined threshold; and (b) selecting cells which are positive for at least one of the parameters, thereby sorting RPE cells from a mixed population of cells.
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公开(公告)号：US20150010922A1
公开(公告)日：2015-01-08
申请号：US14375195
申请日：2013-01-29
Inventor： Benjamin Eithan Reubinoff , Nurit Yachimovich-Cohen , Limor Matzrafi
IPC: G01N33/52
CPC classification number: G01N33/56966 , C12N5/0621 , C12N2501/15 , C12N2501/16 , C12N2506/45 , C12N2509/00 , G01N21/6486 , G01N33/52 , G01N33/582 , G01N2021/4704 , G01N2333/46
Abstract: A method of selecting retinal pigmented epithelial (RPE) cells from a mixed population of cells is disclosed. The method comprises: (a) analyzing the cells of the mixed population of cells for at least one of the following parameters: (i) cells which autofluorescence above a predetermined threshold; (ii) cells which express CD81 above a predetermined threshold; and (iii) cells which scatter light perpendicular to a laser beam above a predetermined threshold; and (b) selecting cells which are positive for at least one of the parameters, thereby sorting RPE cells from a mixed population of cells.
Abstract translation: 公开了从混合细胞群中选择视网膜色素上皮（RPE）细胞的方法。 该方法包括：（a）分析混合细胞群体的细胞中至少一个以下参数：（i）自发荧光高于预定阈值的细胞; （ii）表达CD81高于预定阈值的细胞; 和（iii）将垂直于激光束的光散射到预定阈值以上的单元; 和（b）选择对至少一个参数是阳性的细胞，从而从混合的细胞群中分选RPE细胞。
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公开(公告)号：US20230028133A1
公开(公告)日：2023-01-26
申请号：US17943462
申请日：2022-09-13
Applicant: CELL CURE NEUROSCIENCES LTD.
Inventor： Eyal Banin , Benjamin Eithan Reubinoff , Osnat Bohana-Kashtan , Nir Netzer , Charles Sherard Irving
Abstract: A method of treating a subject with dry-form age-related macular degeneration (AMD) is disclosed. The method comprises administering into the subretina of the subject a therapeutically effective amount of a pharmaceutical composition comprising human RPE cells, wherein at least 95% of the cells thereof co-express premelanosome protein (PMEL17) and cellular retinaldehyde binding protein (CRALBP), and wherein the trans-epithelial electrical resistance of the cells is greater than 100 ohms to the subject, thereby treating the subject.
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公开(公告)号：US12188047B2
公开(公告)日：2025-01-07
申请号：US15771046
申请日：2016-10-26
Inventor： Benjamin Eithan Reubinoff , Orna Singer , Osnat Bohana-Kashtan , Ofer Wiser
IPC: C12N5/079 , C12N5/00 , C12N5/0735 , G01N33/53
Abstract: A method of generating retinal pigment epithelium cells is disclosed. Cell populations comprising same and uses thereof are also disclosed.
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公开(公告)号：US11035857B2
公开(公告)日：2021-06-15
申请号：US15470926
申请日：2017-03-28
Inventor： Benjamin Eithan Reubinoff , Nurit Yachimovich-Cohen , Limor Matzrafi
Abstract: A method of selecting retinal pigmented epithelial (RPE) cells from a mixed population of cells is disclosed. The method comprises: (a) analyzing the cells of the mixed population of cells for at least one of the following parameters: (i) cells which autofluorescence above a predetermined threshold; (ii) cells which express CD81 above a predetermined threshold; and (iii) cells which scatter light perpendicular to a laser beam above a predetermined threshold; and (b) selecting cells which are positive for at least one of the parameters, thereby sorting RPE cells from a mixed population of cells.
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