公开(公告)号：US10894023B2

公开(公告)日：2021-01-19

申请号：US16446634

申请日：2019-06-20

Applicant: Center Laboratories, Inc. ,  Medical and Pharmaceutical Industry Technology and Development Center

Inventor： Meng-Ju Lee ,  Shu-Hsien Chang ,  Chih-Chiang Yang ,  Yuan-Chih Le ,  Tse-Ching Lin ,  Ko-Chiang Chen ,  Lai-Cheng Chin ,  Tai-Yin Ke ,  Pei-Ying Liao

IPC: A61K31/13 ,  A61K31/445 ,  A61K9/16 ,  A61K9/50 ,  A61K9/48 ,  A61K9/00 ,  A61P25/16 ,  A61P25/14 ,  A61P25/28

Abstract: Disclosed herein is an oral dosage formulation suitable for treating a neurodegenerative disorder. The oral dosage formulation contains both sustained-release and immediate-release drugs. The sustained-release drug in the oral dosage formulation is memantine, and the immediate-release drug in the oral dosage formulation is donepezil and/or memantine, and the formulation is characterized in having a pH-independent dissolution profile of memantine at a pH range from about 1.0 to about 7.0.

公开(公告)号：US10278943B2

公开(公告)日：2019-05-07

申请号：US15957956

申请日：2018-04-20

Applicant: Center Laboratories, Inc.

Inventor： Jui-Pao Hsu ,  Guang-Tzuu Shane ,  Meng-Ju Lee ,  Yi-Ping Liao ,  Yu-Yin Yeh

IPC: A61K31/277 ,  A61K31/155 ,  A61K45/06

Abstract: Disclosed herein are methods for treating conditions and/or disorders related to hyperglycemia. Such conditions and/or disorders related to hyperglycemia include, but are not limited to, type I, II diabetes mellitus, gestational diabetes, other forms diabetes, and disorders related thereto. In particular, the present invention relates to methods of using (R)-(+)-verapamil or a pharmaceutically acceptable salt thereof in the treatment of conditions and/or disorders related to hyperglycemia.

公开(公告)号：US10144704B2

公开(公告)日：2018-12-04

申请号：US15917817

申请日：2018-03-11

Applicant: Center Laboratories, Inc.

Inventor： Jui-Pao Hsu ,  Guang-Tzuu Shane ,  Yu-Yin Yeh ,  Meng-Ju Lee

IPC: C07C253/34 ,  C07C255/43

Abstract: Novel crystal forms of (R)-(+)-verapamil hydrochloride are disclosed.

公开(公告)号：US09950995B2

公开(公告)日：2018-04-24

申请号：US15521304

申请日：2015-07-13

Applicant: Center Laboratories, Inc.

Inventor： Jui-Pao Hsu ,  Guang-Tzuu Shane ,  Yu-Yin Yeh ,  Meng-Ju Lee

IPC: C07C255/00 ,  C07C255/43 ,  C07C253/34

CPC classification number: C07C255/43 ,  C07B2200/13 ,  C07C253/34

Abstract: Novel crystal forms of (R)-(−)-verapamil hydrochloride are disclosed.

公开(公告)号：US09980935B2

公开(公告)日：2018-05-29

申请号：US15597200

申请日：2017-05-17

Applicant: Center Laboratories, Inc.

Inventor： Jui-Pao Hsu ,  Guang-Tzuu Shane ,  Meng-Ju Lee ,  Yi-Ping Liao ,  Yu-Yin Yeh

IPC: A61K31/277 ,  A61K31/155 ,  A61K45/06

CPC classification number: A61K31/277 ,  A61K31/155 ,  A61K45/06 ,  A61K2300/00

Abstract: Disclosed herein are methods for treating conditions and/or disorders related to hyperglycemia. Such conditions and/or disorders related to hyperglycemia include, but are not limited to, type I, II diabetes mellitus, gestational diabetes, other forms diabetes, and disorders related thereto. In particular, the present invention relates to methods of using (R)-(+)-verapamil or a pharmaceutically acceptable salt thereof in the treatment of conditions and/or disorders related to hyperglycemia.