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公开(公告)号:US10745736B2
公开(公告)日:2020-08-18
申请号:US15514956
申请日:2015-10-01
发明人: Jeffrey Meyer , Ken Evans , Jian Chen , Suzanne Ackloo , Moyez Dharsee
IPC分类号: C12Q1/68 , G01N33/567 , C12Q1/26 , C40B40/10 , C12N9/06 , C07K7/08 , C07K7/06 , A61B5/11 , A61B5/145 , G01N33/50
摘要: Disclosed is a method for diagnosing a mood disorder or susceptibility to a mood disorder, including depressive disorders and bipolar disorder, from a biological sample taken from a subject. The method includes detecting markers of monoamine oxidase-A (MAO-A) in the biological sample; determining MAO-A concentration from the markers; and correlating the MAO-A concentration in the biological sample to a control group which does not have a mood disorder in order to diagnose or determine susceptibility to the mood disorder in the subject. Also disclosed is a method of detecting peripheral markers of MAO-A for the diagnosis of a mood disorder or susceptibility to a mood disorder. Also provided are polypeptide markers.
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公开(公告)号:US20170226559A1
公开(公告)日:2017-08-10
申请号:US15514956
申请日:2015-10-01
发明人: Jeffrey Meyer , Ken Evans , Jian Chen , Suzanne Ackloo , Moyez Dharsee
CPC分类号: C12Q1/26 , A61B5/1127 , A61B5/145 , C07K7/06 , C07K7/08 , C12N9/0022 , C12Q1/68 , C12Y104/03004 , C40B40/10 , G01N33/5008 , G01N2333/90638 , G01N2560/00 , G01N2800/304
摘要: Disclosed is a method for diagnosing a mood disorder or susceptibility to a mood disorder, including depressive disorders and bipolar disorder, from a biological sample taken from a subject. The method includes detecting markers of monoamine oxidase-A (MAO-A) in the biological sample; determining MAO-A concentration from the markers; and correlating the MAO-A concentration in the biological sample to a control group which does not have a mood disorder in order to diagnose or determine susceptibility to the mood disorder in the subject. Also disclosed is a method of detecting peripheral markers of MAO-A for the diagnosis of a mood disorder or susceptibility to a mood disorder. Also provided are polypeptide markers.
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