公开(公告)号：US08633173B2

公开(公告)日：2014-01-21

申请号：US13920153

申请日：2013-06-18

Applicant: Cephalon, Inc.

Inventor： Matthew A. Curry ,  Bruce D. Dorsey ,  Benjamin J. Dugan ,  Diane E. Gingrich ,  Eugen F. Mesaros ,  Karen L. Milkiewicz

IPC: A61K31/675 ,  A61K31/437 ,  A61K31/496 ,  A61K31/5377 ,  A61K31/541 ,  A61K31/55

CPC classification number: C07D471/04

Abstract: This application relates, in part, to compounds of the general Formula I and/or salts thereof, wherein X, R1A, R1B, R2, R3, R4, and R5 are as defined herein. The application also relates to compositions and methods of inhibiting at least JAK2 in subjects in recognized need thereof for the treatment of diseases or disorders for which inhibition of at least JAK2 is indicated.

Abstract translation: 本申请部分涉及通式I和/或其盐的化合物，其中X，R 1A，R 1B，R 2，R 3，R 4和R 5如本文所定义。 本申请还涉及在认可需要的受试者中至少抑制JAK2以治疗至少表达JAK2的抑制的疾病或病症的组合物和方法。

公开(公告)号：US20140113882A1

公开(公告)日：2014-04-24

申请号：US14038915

申请日：2013-09-27

Applicant: Cancer Research Technology Limited ,  Cephalon, Inc.

Inventor： Henry J. Breslin ,  Bruce D. Dorsey ,  Benjamin J. Dugan ,  Katherine M. Fowler ,  Robert L. Hudkins ,  Eugen F. Mesaros ,  Nathaniel J.T. Monck ,  Emma L. Morris ,  Ikeoluwa Olowoye ,  Gregory R. Ott ,  Gregoire A. Pave ,  Jonathan R. Roffey ,  Christelle N. Soudy ,  Ming Tao ,  Craig A. Zificsak ,  Allison L. Zulli

IPC: C07D471/04 ,  C07F9/6584 ,  C07D498/04 ,  C07D493/08

CPC classification number: C07D471/04 ,  C07D493/08 ,  C07D498/04 ,  C07D519/00 ,  C07F9/6584

Abstract: The present application provides a compound of formula (I) or a salt thereof, wherein R7, R8, R9, G, and X are as defined herein. This application further describes compositions comprising the same. Compounds of formula (I) and their salts have aPKC inhibitory activity, and may be used to treat proliferative disorders.

Abstract translation: 本申请提供式（I）化合物或其盐，其中R 7，R 8，R 9，G和X如本文所定义。 本申请进一步描述了包含该组合物的组合物。 式（I）化合物及其盐具有PKC抑制活性，可用于治疗增殖性疾病。

公开(公告)号：US20130296312A1

公开(公告)日：2013-11-07

申请号：US13920153

申请日：2013-06-18

Applicant: Cephalon, Inc.

Inventor： Matthew A. Curry ,  Bruce D. Dorsey ,  Benjamin J. Dugan ,  Diane E. Gingrich ,  Eugen F. Mesaros ,  Karen L. Milkiewicz

IPC: C07D471/04

CPC classification number: C07D471/04

Abstract: This application relates, in part, to compounds of the general Formula I and/or salts thereof, wherein X, R1A, R1B, R2, R3, R4, and R5 are as defined herein. The application also relates to compositions and methods of inhibiting at least JAK2 in subjects in recognized need thereof for the treatment of diseases or disorders for which inhibition of at least JAK2 is indicated.

Abstract translation: 本申请部分涉及通式I和/或其盐的化合物，其中X，R 1A，R 1B，R 2，R 3，R 4和R 5如本文所定义。 本申请还涉及在认可需要的受试者中至少抑制JAK2以治疗至少表达JAK2的抑制的疾病或病症的组合物和方法。