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公开(公告)号：US20140113882A1
公开(公告)日：2014-04-24
申请号：US14038915
申请日：2013-09-27
发明人： Henry J. Breslin , Bruce D. Dorsey , Benjamin J. Dugan , Katherine M. Fowler , Robert L. Hudkins , Eugen F. Mesaros , Nathaniel J.T. Monck , Emma L. Morris , Ikeoluwa Olowoye , Gregory R. Ott , Gregoire A. Pave , Jonathan R. Roffey , Christelle N. Soudy , Ming Tao , Craig A. Zificsak , Allison L. Zulli
IPC分类号： C07D471/04 , C07F9/6584 , C07D498/04 , C07D493/08
CPC分类号： C07D471/04 , C07D493/08 , C07D498/04 , C07D519/00 , C07F9/6584
摘要： The present application provides a compound of formula (I) or a salt thereof, wherein R7, R8, R9, G, and X are as defined herein. This application further describes compositions comprising the same. Compounds of formula (I) and their salts have aPKC inhibitory activity, and may be used to treat proliferative disorders.
摘要翻译： 本申请提供式（I）化合物或其盐，其中R 7，R 8，R 9，G和X如本文所定义。 本申请进一步描述了包含该组合物的组合物。 式（I）化合物及其盐具有PKC抑制活性，可用于治疗增殖性疾病。
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公开(公告)号：US11020396B2
公开(公告)日：2021-06-01
申请号：US16348073
申请日：2017-11-07
发明人： Emma L. Carswell , Mark David Charles , Chukuemeka Tennyson Ekwuru , Frederic Elustondo , Katherine M. Fowler , Gregory R. Ott , Jonathan R. Roffey , Joanna L. Brookfield , Daniel James Ford , Mathew L. Calder
IPC分类号： C07D403/14 , A61K31/506 , A61K31/437 , A61K31/551 , C07D413/14 , C07D417/14 , C07D471/04
摘要： The present invention relates to compounds of formula I as defined herein, and salts and solvates thereof, that function as inhibitors of cell division cycle 7 (Cdc7) kinase enzyme activity. The present invention also relates to pharmaceutical compositions comprising them, and to their use in the treatment of proliferative disorders, such as cancer, as well as other diseases or conditions in which Cdc7 kinase activity is implicated.
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公开(公告)号：US09914730B2
公开(公告)日：2018-03-13
申请号：US14038915
申请日：2013-09-27
发明人： Henry J. Breslin , Bruce D. Dorsey , Benjamin J Dugan , Katherine M. Fowler , Robert L Hudkins , Eugen F. Mesaros , Nathaniel J. T. Monck , Emma L. Morris , Ikeoluwa Olowoye , Gregory R. Ott , Gregoire A. Pave , Jonathan R. Roffey , Christelle N. Soudy , Ming Tao , Craig A. Zificsak , Allison L. Zulli
IPC分类号： A61K31/675 , C07D471/04 , C07D519/00 , C07D493/08 , C07D498/04 , C07F9/6584
CPC分类号： C07D471/04 , C07D493/08 , C07D498/04 , C07D519/00 , C07F9/6584
摘要： The present application provides azaquinazoline compounds as defined herein. This application further describes compositions comprising the same. These azaquinazoline compounds and their salts have atypical protein kinase C (“aPKC”) inhibitory activity, and may be used to treat proliferative disorders.
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公开(公告)号：US11766434B2
公开(公告)日：2023-09-26
申请号：US17244171
申请日：2021-04-29
发明人： Emma L. Carswell , Mark David Charles , Chukuemeka Tennyson Ekwuru , Frederic Elustondo , Katherine M. Fowler , Gregory R. Ott , Jonathan R. Roffey , Joanna L. Brookfield , Daniel James Ford , Mathew L. Calder
IPC分类号： A61K31/506 , A61K31/437 , A61K31/551 , C07D403/14 , C07D413/14 , C07D417/14 , C07D471/04
CPC分类号： A61K31/506 , A61K31/437 , A61K31/551 , C07D403/14 , C07D413/14 , C07D417/14 , C07D471/04
摘要： The present invention relates to compounds of formula I as defined herein, and salts and solvates thereof, that function as inhibitors of cell division cycle 7 (Cdc7) kinase enzyme activity. The present invention also relates to pharmaceutical compositions comprising them, and to their use in the treatment of proliferative disorders, such as cancer, as well as other diseases or conditions in which Cdc7 kinase activity is implicated.
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公开(公告)号：US20220079942A1
公开(公告)日：2022-03-17
申请号：US17244171
申请日：2021-04-29
发明人： Emma L. Carswell , Mark David Charles , Chukuemeka Tennyson Ekwuru , Frederic Elustondo , Katherine M. Fowler , Gregory R. Ott , Jonathan R. Roffey , Joanna L. Brookfield , Daniel James Ford , Mathew L. Calder
IPC分类号： A61K31/506 , A61K31/437 , A61K31/551 , C07D403/14 , C07D413/14 , C07D417/14 , C07D471/04
摘要： The present invention relates to compounds of formula I as defined herein, and salts and solvates thereof, that function as inhibitors of cell division cycle 7 (Cdc7) kinase enzyme activity. The present invention also relates to pharmaceutical compositions comprising them, and to their use in the treatment of proliferative disorders, such as cancer, as well as other diseases or conditions in which Cdc7 kinase activity is implicated.
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公开(公告)号：US09896446B2
公开(公告)日：2018-02-20
申请号：US14975605
申请日：2015-12-18
发明人： Henry J. Breslin , Bruce D. Dorsey , Benjamin J. Dugan , Robert L. Hudkins , Eugen F. Mesaros , Gregory R. Ott , Craig A. Zificsak , Allison L. Zulli , Ming Tao , Katherine M. Fowler , Emma L. Morris , Gregoire A. Pave , Jonathan R. A. Roffey , Nathaniel J. T. Monck , Christelle N. Soudy , Ikeoluwa Olowoye
IPC分类号： A61K31/407 , C07D471/04 , C07D519/00 , C07D493/08 , C07D498/04 , C07F9/6584
CPC分类号： C07D471/04 , C07D493/08 , C07D498/04 , C07D519/00 , C07F9/6584
摘要： The present application provides a compound of formula (I) or a salt thereof, wherein R7, R8, R9, G, and X are as defined herein. This application further describes compositions comprising the same. Compounds of formula (I) and their salts have aPKC inhibitory activity, and may be used to treat proliferative diseases.
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公开(公告)号：US20160102094A1
公开(公告)日：2016-04-14
申请号：US14975605
申请日：2015-12-18
发明人： Henry J. Breslin , Bruce D. Dorsey , Benjamin J. Dugan , Robert L. Hudkins , Eugen F. Mesaros , Gregory R. Ott , Craig A. Zificsak , Allison L. Zulli , Ming Tao , Katherine M. Fowler , Emma L. Morris , Gregoire A. Pave , Jonathan R.A. Roffey , Nathaneil J.T. Monck , Christelle N. Soudy , Ikeoluwa Olowoye
IPC分类号： C07D471/04
CPC分类号： C07D471/04 , C07D493/08 , C07D498/04 , C07D519/00 , C07F9/6584
摘要： The present application provides a compound of formula (1) or a salt thereof, wherein R7, R8, R9, G, and X are as defined herein. This application further describes compositions comprising the same. Compounds of formula (I) and their salts have aPKC inhibitory activity, and may be used to treat proliferative diseases.
摘要翻译： 本申请提供式（1）化合物或其盐，其中R 7，R 8，R 9，G和X如本文所定义。 本申请进一步描述了包含该组合物的组合物。 式（I）化合物及其盐具有PKC抑制活性，可用于治疗增殖性疾病。
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公开(公告)号：US20150274720A1
公开(公告)日：2015-10-01
申请号：US14668022
申请日：2015-03-25
发明人： Bruce D. Dorsey , Benjamin J. Dugan , Katherine M. Fowler , Robert L. Hudkins , Eugen F. Mesaros , Nathaniel JT Monck , Emma L. Morris , Ikeoluwa Olowoye , Gregory R. Ott , Gregoire A. Pave , Jonathan R.A. Roffey , Christelle N. Soudy , Craig A. Zificsak , Allison L. Zulli
IPC分类号： C07D471/04 , C07D519/00
CPC分类号： C07D471/04 , A61P35/00 , A61P35/02 , A61P35/04 , C07D519/00
摘要： The present application provides a compound of formula (I) and/or a salt thereof, wherein R1, G, and X are as defined herein. A compound of formula (I) and/or its salts have aPKC inhibitory activity, and may be used to treat proliferative disorders. Compositions comprising a compound of Formula (I) and/or a salt thereof are also provided.
摘要翻译： 本申请提供式（I）化合物和/或其盐，其中R 1，G和X如本文所定义。 式（I）化合物和/或其盐具有PKC抑制活性，可用于治疗增殖性疾病。 还提供了包含式（I）化合物和/或其盐的组合物。
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公开(公告)号：US10919896B2
公开(公告)日：2021-02-16
申请号：US16335379
申请日：2017-09-22
发明人： Emma L. Carswell , Mark David Charles , Anne Cochi , Benjamin J. Dugan , Chukuemeka Tennyson Ekwuru , Fred Elustondo , Katherine M. Fowler , Frederic Georges Marie Leroux , Nathaniel J. T. Monck , Gregory R. Ott , Jonathan R. Roffey , Gurwinder Sidhu , Neil Tremayne
IPC分类号： C07D401/14 , C07D487/02 , A61P35/00
摘要： The present invention relates to compounds of formula (I), and salts and solvates thereof, that function as inhibitors of cell division cycle 7 (Cdc7) kinase enzyme activity: wherein X, R1, R2, and n are each as defined herein. The present invention also relates to processes for the preparation of these compounds, to pharmaceutical compositions comprising them, and to their use in the treatment of proliferative disorders, such as cancer, as well as other diseases or conditions in which Cdc7 kinase activity is implicated.
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公开(公告)号：US20190336502A1
公开(公告)日：2019-11-07
申请号：US16348073
申请日：2017-11-07
发明人： Emma L. Carswell , Mark David Charles , Chukuemeka Tennyson Ekwuru , Frederic Elustondo , Katherine M. Fowler , Gregory R. Ott , Jonathan R. Roffey , Joanna L. Brookfield , Daniel James Ford , Mathew L. Calder
IPC分类号： A61K31/506 , C07D417/14 , A61K31/551 , A61K31/437 , C07D471/04 , C07D403/14 , C07D413/14
摘要： The present invention relates to compounds of formula I as defined herein, and salts and solvates thereof, that function as inhibitors of cell division cycle 7 (Cdc7) kinase enzyme activity. The present invention also relates to pharmaceutical compositions comprising them, and to their use in the treatment of proliferative disorders, such as cancer, as well as other diseases or conditions in which Cdc7 kinase activity is implicated.
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