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公开(公告)号：US20140113882A1
公开(公告)日：2014-04-24
申请号：US14038915
申请日：2013-09-27
发明人： Henry J. Breslin , Bruce D. Dorsey , Benjamin J. Dugan , Katherine M. Fowler , Robert L. Hudkins , Eugen F. Mesaros , Nathaniel J.T. Monck , Emma L. Morris , Ikeoluwa Olowoye , Gregory R. Ott , Gregoire A. Pave , Jonathan R. Roffey , Christelle N. Soudy , Ming Tao , Craig A. Zificsak , Allison L. Zulli
IPC分类号： C07D471/04 , C07F9/6584 , C07D498/04 , C07D493/08
CPC分类号： C07D471/04 , C07D493/08 , C07D498/04 , C07D519/00 , C07F9/6584
摘要： The present application provides a compound of formula (I) or a salt thereof, wherein R7, R8, R9, G, and X are as defined herein. This application further describes compositions comprising the same. Compounds of formula (I) and their salts have aPKC inhibitory activity, and may be used to treat proliferative disorders.
摘要翻译： 本申请提供式（I）化合物或其盐，其中R 7，R 8，R 9，G和X如本文所定义。 本申请进一步描述了包含该组合物的组合物。 式（I）化合物及其盐具有PKC抑制活性，可用于治疗增殖性疾病。
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公开(公告)号：US09896446B2
公开(公告)日：2018-02-20
申请号：US14975605
申请日：2015-12-18
发明人： Henry J. Breslin , Bruce D. Dorsey , Benjamin J. Dugan , Robert L. Hudkins , Eugen F. Mesaros , Gregory R. Ott , Craig A. Zificsak , Allison L. Zulli , Ming Tao , Katherine M. Fowler , Emma L. Morris , Gregoire A. Pave , Jonathan R. A. Roffey , Nathaniel J. T. Monck , Christelle N. Soudy , Ikeoluwa Olowoye
IPC分类号： A61K31/407 , C07D471/04 , C07D519/00 , C07D493/08 , C07D498/04 , C07F9/6584
CPC分类号： C07D471/04 , C07D493/08 , C07D498/04 , C07D519/00 , C07F9/6584
摘要： The present application provides a compound of formula (I) or a salt thereof, wherein R7, R8, R9, G, and X are as defined herein. This application further describes compositions comprising the same. Compounds of formula (I) and their salts have aPKC inhibitory activity, and may be used to treat proliferative diseases.
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公开(公告)号：US20160102094A1
公开(公告)日：2016-04-14
申请号：US14975605
申请日：2015-12-18
发明人： Henry J. Breslin , Bruce D. Dorsey , Benjamin J. Dugan , Robert L. Hudkins , Eugen F. Mesaros , Gregory R. Ott , Craig A. Zificsak , Allison L. Zulli , Ming Tao , Katherine M. Fowler , Emma L. Morris , Gregoire A. Pave , Jonathan R.A. Roffey , Nathaneil J.T. Monck , Christelle N. Soudy , Ikeoluwa Olowoye
IPC分类号： C07D471/04
CPC分类号： C07D471/04 , C07D493/08 , C07D498/04 , C07D519/00 , C07F9/6584
摘要： The present application provides a compound of formula (1) or a salt thereof, wherein R7, R8, R9, G, and X are as defined herein. This application further describes compositions comprising the same. Compounds of formula (I) and their salts have aPKC inhibitory activity, and may be used to treat proliferative diseases.
摘要翻译： 本申请提供式（1）化合物或其盐，其中R 7，R 8，R 9，G和X如本文所定义。 本申请进一步描述了包含该组合物的组合物。 式（I）化合物及其盐具有PKC抑制活性，可用于治疗增殖性疾病。
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公开(公告)号：US09914730B2
公开(公告)日：2018-03-13
申请号：US14038915
申请日：2013-09-27
发明人： Henry J. Breslin , Bruce D. Dorsey , Benjamin J Dugan , Katherine M. Fowler , Robert L Hudkins , Eugen F. Mesaros , Nathaniel J. T. Monck , Emma L. Morris , Ikeoluwa Olowoye , Gregory R. Ott , Gregoire A. Pave , Jonathan R. Roffey , Christelle N. Soudy , Ming Tao , Craig A. Zificsak , Allison L. Zulli
IPC分类号： A61K31/675 , C07D471/04 , C07D519/00 , C07D493/08 , C07D498/04 , C07F9/6584
CPC分类号： C07D471/04 , C07D493/08 , C07D498/04 , C07D519/00 , C07F9/6584
摘要： The present application provides azaquinazoline compounds as defined herein. This application further describes compositions comprising the same. These azaquinazoline compounds and their salts have atypical protein kinase C (“aPKC”) inhibitory activity, and may be used to treat proliferative disorders.
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![Imidazo[4,5-b]pyridine derivatives as ALK and JAK modulators for the treatment of proliferative disorders](/abs-image/US/2016/01/19/US09238656B2/abs.jpg.150x150.jpg)
5.发明授权Imidazo[4,5-b]pyridine derivatives as ALK and JAK modulators for the treatment of proliferative disorders 有权咪唑并[4,5-b]吡啶衍生物作为ALK和JAK调节剂用于治疗增殖性疾病公开(公告)号：US09238656B2
公开(公告)日：2016-01-19
申请号：US14446411
申请日：2014-07-30
申请人： Cephalon, Inc.
发明人： Henry J. Breslin , Matthew A. Curry , Diane E. Gingrich , Keith S. Learn , Gregory R. Ott , Jason C. Wagner
IPC分类号： C07D493/08 , C07D491/107 , C07D471/04 , A61K31/47 , A61K31/437 , A61K31/444 , A61K31/4545 , A61K31/496 , A61K31/506 , A61K31/5377 , A61P35/00
CPC分类号： C07D493/08 , C07D471/04 , C07D491/107
摘要： This application relates to compounds of the Formula I as defined herein, and/or salts thereof. This application further relates to compositions and methods of using these compounds and/or salts thereof. The compounds of Formula I are useful as ALK and JAK modulators for the treatment of proliferative disorders.
摘要翻译： 本申请涉及本文定义的式I化合物和/或其盐。 本申请还涉及使用这些化合物和/或其盐的组合物和方法。 式I的化合物可用作治疗增殖性疾病的ALK和JAK调节剂。
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公开(公告)号：US09487529B2
公开(公告)日：2016-11-08
申请号：US14025986
申请日：2013-09-13
申请人： Cephalon, Inc.
IPC分类号： C07D487/08 , C07D487/18
CPC分类号： A61K31/529 , A61K31/5377 , C07D487/08 , C07D487/18
摘要： The present invention provides compounds of Formula I or a pharmaceutically acceptable salt forms thereof, wherein R1, R2, R3, R4, R5, A and X are as defined herein, methods of treatment and uses thereof.
摘要翻译： 或其药学上可接受的盐形式，其中R 1，R 2，R 3，R 4，R 5，A和X如本文所定义，其处理方法及其用途。
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![Imidazo[4,5-b]pyridine Derivatives as ALK and JAK Modulators for the Treatment of Proliferative Disorders](/abs-image/US/2014/11/27/US20140350011A1/abs.jpg.150x150.jpg)
7.发明申请Imidazo[4,5-b]pyridine Derivatives as ALK and JAK Modulators for the Treatment of Proliferative Disorders 有权咪唑并[4,5-b]吡啶衍生物作为ALK和JAK调节剂治疗增殖性疾病公开(公告)号：US20140350011A1
公开(公告)日：2014-11-27
申请号：US14446411
申请日：2014-07-30
申请人： Cephalon, Inc.
发明人： Henry J. Breslin , Matthew A. Curry , Diane E. Gingrich , Keith S. Learn , Gregory R. Ott , Jason C. Wagner
IPC分类号： C07D493/08 , C07D491/107 , C07D471/04
CPC分类号： C07D493/08 , C07D471/04 , C07D491/107
摘要： This application relates to compounds of the Formula I as defined herein, and/or salts thereof. This application further relates to compositions and methods of using these compounds and/or salts thereof. The compounds of Formula I are useful as ALK and JAK modulators for the treatment of proliferative disorders.
摘要翻译： 本申请涉及本文定义的式I化合物和/或其盐。 本申请还涉及使用这些化合物和/或其盐的组合物和方法。 式I的化合物可用作治疗增殖性疾病的ALK和JAK调节剂。
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公开(公告)号：US20170027948A1
公开(公告)日：2017-02-02
申请号：US15292468
申请日：2016-10-13
申请人： Cephalon, Inc.
IPC分类号： A61K31/529 , A61K31/5377
CPC分类号： A61K31/529 , A61K31/5377 , C07D487/08 , C07D487/18
摘要： The present invention provides compounds of Formula I or a pharmaceutically acceptable salt forms thereof, wherein R1, R2, R3, R4, R5, A and X are as defined herein, methods of treatment and uses thereof.
摘要翻译： 或其药学上可接受的盐形式，其中R 1，R 2，R 3，R 4，R 5，A和X如本文所定义，其处理方法及其用途。
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公开(公告)号：US20140031351A1
公开(公告)日：2014-01-30
申请号：US14025986
申请日：2013-09-13
申请人： Cephalon, Inc.
IPC分类号： C07D487/08
CPC分类号： A61K31/529 , A61K31/5377 , C07D487/08 , C07D487/18
摘要： The present invention provides compounds of Formula I or a pharmaceutically acceptable salt forms thereof, wherein R1, R2, R3, R4, R5, A and X are as defined herein, methods of treatment and uses thereof.
摘要翻译： 本发明提供式I化合物或其药学上可接受的盐形式，其中R 1，R 2，R 3，R 4，R 5，A和X如本文所定义，其处理方法及其用途。
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