利索-全球专利检索

  1. 登录
  2. 注册

搜索结果

20 条记录 (耗时 0.017 秒)

    Nanoparticle probes with raman spectroscopic fingerprints for analyte detection
    2.
    发明授权
    Nanoparticle probes with raman spectroscopic fingerprints for analyte detection 有权
    具有拉曼光谱指纹的纳米粒子探针用于分析物检测

    公开(公告)号：US07985539B2

    公开(公告)日：2011-07-26

    申请号：US10431341

    申请日：2003-05-07

    申请人： Chad A. Mirkin ,  Yunwei Cao ,  Rongchao Jin

    发明人： Chad A. Mirkin ,  Yunwei Cao ,  Rongchao Jin

    IPC分类号： C12Q1/68 ,  G01N33/53

    CPC分类号： G01N33/587 ,  C12Q1/6816 ,  G01N33/54373 ,  G01N33/583 ,  Y02A50/54 ,  C12Q2565/632 ,  C12Q2565/519 ,  C12Q2537/125

    摘要： The invention encompasses reagents comprising particles with at least one Raman dye and a specific binding members bound thereto and methods of using such reagents. The invention also encompasses reagents of a specific binding member and two or more different Raman dyes and methods for using such reagents. New types of particle probes having a specific binding member bound thereto are described. These reagents are used in a novel detection strategy that utilizes the catalytic properties of the Au nanoparticles to generate a silver coating that can behave as a surface-enhanced Raman scattering (SERS) promoter for the dye-labeled particles that have been captured by target and an underlying chip in microarray format. The strategy provides the high sensitivity and high selectivity attributes of grey-scale scanometric detection but provides a route to multiplexing and ratioing capabilities since a very large number of probes can be designed based upon the concept of using a Raman tag as a spectroscopic fingerprint in detection. These spectra are used as fingerprints to differentiate oligonucleotide or other targets in one solution. This method has been used to distinguish six dissimilar DNA targets with six Raman labeled nanoparticle probes, and also two RNA targets with single nucleotide polymorphisms (SNPs).

    摘要翻译： 本发明包括含有至少一种拉曼染料和与其结合的特异性结合成员的颗粒的试剂和使用这些试剂的方法。 本发明还包括特异性结合成员和两种或更多种不同拉曼染料的试剂和使用这些试剂的方法。 描述具有与其结合的特异性结合成员的新型粒子探针。 这些试剂用于一种新的检测策略，其利用Au纳米粒子的催化性能产生可以作为被目标捕获的染料标记的颗粒的表面增强拉曼散射（SERS）启动子的银涂层， 微芯片格式的底层芯片。 该策略提供了灰度扫描测量检测的高灵敏度和高选择性属性，但是提供了多路复用和比较能力的途径，因为可以基于在检测中使用拉曼标签作为光谱指纹的概念来设计非常大量的探针 。 这些光谱用作指纹以在一种溶液中区分寡核苷酸或其他靶标。 该方法已被用于区分六个不同的DNA靶标与六个拉曼标记的纳米颗粒探针，以及两个具有单核苷酸多态性（SNPs）的RNA靶标。

    METHODS OF MAKING NANOPRISMS
    3.
    发明申请
    METHODS OF MAKING NANOPRISMS 失效
    制备纳米材料的方法

    公开(公告)号：US20090308202A1

    公开(公告)日：2009-12-17

    申请号：US11499024

    申请日：2006-08-04

    申请人： Rongchao Jin ,  Yunwei Cao ,  Chad A. Mirkin

    发明人： Rongchao Jin ,  Yunwei Cao ,  Chad A. Mirkin

    IPC分类号： B22F9/16

    CPC分类号： B82Y30/00 ,  B22F1/0018 ,  B22F9/24 ,  B22F2001/0037 ,  B22F2999/00 ,  C22C5/06 ,  Y10S977/773 ,  Y10S977/81 ,  B22F2202/11

    摘要： The invention is a novel photo-induced method for converting large quantities of silver nanospheres into nanoprisms, the nanoprisms formed by this method and applications in which the nanoprisms are useful. Significantly, this light driven process results in a colloid with a unique set of optical properties that directly relate to the nanoprism shape of the particles. Theoretical calculations coupled with experimental observations allow for the assignment of the nanoprism plasmon bands and the first identification of two distinct quadrupole plasmon resonances for a nanoparticle. Finally, unlike the spherical particles from which they derive and which Rayleigh light scatter in the blue, these nanoprisms exhibit-scattering in the red, permitting multicolor diagnostic labels based not only on nanoparticle composition and size but also on shape.

    摘要翻译： 本发明是一种用于将大量银纳米球转化为纳米棱镜的新型光诱导方法，该方法形成的纳米棱镜以及纳米棱镜可用的应用。 重要的是，这种光驱过程导致具有与粒子的纳米棱镜形状直接相关的独特的光学性质的胶体。 与实验观察结合的理论计算允许分配纳米棱镜等离子体激元带并且对于纳米颗粒首次鉴定两种不同的四极等离子体共振。 最后，不同于它们衍生的球形颗粒和蓝色的瑞利光散射，这些纳米棱镜在红色中表现出散射，允许多色诊断标签不仅基于纳米颗粒的组成和尺寸，而且基于形状。

    Methods of making nanoprisms
    4.
    发明授权
    Methods of making nanoprisms 失效
    制作纳米棱镜的方法

    公开(公告)号：US07648595B2

    公开(公告)日：2010-01-19

    申请号：US11499024

    申请日：2006-08-04

    申请人： Rongchao Jin ,  Yunwei Cao ,  Chad A. Mirkin

    发明人： Rongchao Jin ,  Yunwei Cao ,  Chad A. Mirkin

    IPC分类号： B22F9/00

    CPC分类号： B82Y30/00 ,  B22F1/0018 ,  B22F9/24 ,  B22F2001/0037 ,  B22F2999/00 ,  C22C5/06 ,  Y10S977/773 ,  Y10S977/81 ,  B22F2202/11

    摘要： The invention is a novel photo-induced method for converting large quantities of silver nanospheres into nanoprisms, the nanoprisms formed by this method and applications in which the nanoprisms are useful. Significantly, this light driven process results in a colloid with a unique set of optical properties that directly relate to the nanoprism shape of the particles. Theoretical calculations coupled with experimental observations allow for the assignment of the nanoprism plasmon bands and the first identification of two distinct quadrupole plasmon resonances for a nanoparticle. Finally, unlike the spherical particles from which they derive and which Rayleigh light scatter in the blue, these nanoprisms exhibit scattering in the red, permitting multicolor diagnostic labels based not only on nanoparticle composition and size but also on shape.

    摘要翻译： 本发明是一种用于将大量银纳米球转化为纳米棱镜的新型光诱导方法，该方法形成的纳米棱镜以及纳米棱镜可用的应用。 重要的是，这种光驱过程导致具有与粒子的纳米棱镜形状直接相关的独特的光学性质的胶体。 与实验观察结合的理论计算允许分配纳米棱镜等离子体激元带并且对于纳米颗粒首次鉴定两种不同的四极等离子体共振。 最后，不同于它们衍生的球形颗粒和蓝色的瑞利光散射，这些纳米棱镜在红色中表现出散射，允许多色诊断标签不仅基于纳米颗粒的组成和尺寸，而且基于形状。

    Nanoprisms and method of making them
    5.
    发明授权
    Nanoprisms and method of making them 有权

    公开(公告)号：US07135054B2

    公开(公告)日：2006-11-14

    申请号：US10256875

    申请日：2002-09-26

    申请人： Rongchao Jin ,  Yunwei Cao ,  Chad A. Mirkin

    发明人： Rongchao Jin ,  Yunwei Cao ,  Chad A. Mirkin

    IPC分类号： C22C5/06

    CPC分类号： B82Y30/00 ,  B22F1/0018 ,  B22F9/24 ,  B22F2001/0037 ,  B22F2999/00 ,  C22C5/06 ,  Y10S977/773 ,  Y10S977/81 ,  B22F2202/11

    摘要： The invention is a novel photo-induced method for converting large quantities of silver nanospheres into nanoprisms, the nanoprisms formed by this method and applications in which the nanoprisms are useful. Significantly, this light driven process results in a colloid with a unique set of optical properties that directly relate to the nanoprism shape of the particles. Theoretical calculations coupled with experimental observations allow for the assignment of the nanoprism plasmon bands and the first identification of two distinct quadrupole plasmon resonances for a nanoparticle. Finally, unlike the spherical particles from which they derive and which Rayleigh light scatter in the blue, these nanoprisms exhibit scattering in the red, permitting multicolor diagnostic labels based not only on nanoparticle composition and size but also on shape.

    Methods of controlling nanoparticle growth
    7.
    发明授权
    Methods of controlling nanoparticle growth 失效
    控制纳米颗粒生长的方法

    公开(公告)号：US07033415B2

    公开(公告)日：2006-04-25

    申请号：US10817754

    申请日：2004-04-02

    申请人： Chad A. Mirkin ,  Gabriella S. Métraux ,  Rongchao Jin ,  YunWei Charles Cao

    发明人： Chad A. Mirkin ,  Gabriella S. Métraux ,  Rongchao Jin ,  YunWei Charles Cao

    IPC分类号： C22C5/06 ,  B22F1/00

    CPC分类号： B22F1/0014 ,  B22F1/0018 ,  B22F1/0022 ,  B22F9/24 ,  B22F2001/0037 ,  B22F2998/00 ,  B22F2999/00 ,  B82Y30/00 ,  B22F2202/11

    摘要： The invention provides new types of plasmon-driven growth mechanism for silver nanostructures involving the fusion of triangular nanoprisms. This mechanism, which is plasmon excitation-driven and highly cooperative, produces bimodal particle size distributions. In these methods, the growth process can be selectively switched between bimodal and unimodal distributions using dual beam illumination of the nanoparticles. This type of cooperative photo-control over nanostructure growth enables synthesis of monodisperse nanoprisms with a preselected edge length in the 30–120 nm range simply by using one beam to turn off bimodal growth and the other (varied over the 450–700 nm range) for controlling particle size.

    摘要翻译： 本发明提供了涉及三角形纳米棱镜融合的银纳米结构的新型等离子激元驱动生长机制。 这种机制是等离子体激发驱动和高度协作的，产生双峰粒度分布。 在这些方法中，生长过程可以使用纳米颗粒的双光束照射在双峰和单峰分布之间有选择地转换。 这种类型的纳米结构生长的协同光控制可以简单地通过使用一个光束来关闭双峰生长而另一个（在450-700nm范围内变化）来合成具有30-120nm范围内的预选边缘长度的单分散纳米棱镜， 用于控制粒度。