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11 条记录 (耗时 0.019 秒)

    Macrolactams by engineered biosynthesis
    2.
    发明授权
    Macrolactams by engineered biosynthesis 失效
    通过工程化生物合成的新戊酰胺

    公开(公告)号：US07855192B2

    公开(公告)日：2010-12-21

    申请号：US12011068

    申请日：2008-01-23

    申请人： Gary W. Ashley ,  Hugo Menzella ,  Janice Lau Wee ,  John R. Carney

    发明人： Gary W. Ashley ,  Hugo Menzella ,  Janice Lau Wee ,  John R. Carney

    IPC分类号： C07D225/06 ,  A61K31/395 ,  A61P35/00

    CPC分类号： C12P17/10 ,  C07D225/06

    摘要： Macrolactams are made by feeding aromatic amino acids as replacement starter units to a mutant strain of the geldanamycin-producing microorganism Streptomyces hygroscopicus var. geldanus NRRL 3602, wherein the gene cluster encoding enzymes for the biosynthesis of the natural starter unit 3-amino-5-hydroxybenzoic acid has been deleted.

    摘要翻译： 通过将芳香族氨基酸作为替代起始单位加入到产生格尔德霉素的微生物链霉菌吸湿链霉菌变异体的突变菌株中来制备麦芽糖内酰胺。 格尔氏菌NRRL 3602，其中编码天然起始单元3-氨基-5-羟基苯甲酸生物合成酶的基因簇已被缺失。

    Tension rod
    3.
    发明授权
    Tension rod 有权
    拉杆

    公开(公告)号：US08479932B2

    公开(公告)日：2013-07-09

    申请号：US13068354

    申请日：2011-05-09

    申请人： John R. Carney

    发明人： John R. Carney

    IPC分类号： A47H1/08 ,  E04G25/08 ,  F16B7/10

    CPC分类号： A47H1/022 ,  Y10T403/32501 ,  Y10T403/5726

    摘要： A tension rod comprising in its preferred form an outer tube and an inner tube in a telescoping arrangement. The outer tube has an expansion joint structure which can engage the inner surface of the outer tube to hold it in place. A spring stem-wedge-rod structure has a wedge portion with a threaded rod extending therefrom for being threaded through a nut held in the expansion rod structure. The spring stem-wedge-rod structure has a stem extending through a coil spring, and a spring retainer is fixed both to the stem and to the inner tube. Twisting of the inner tube causes the wedge portion to effect the expansion joint structure to be fixed in the outer tube, and the coil spring provides the tension to mount the tension rod between a pair of opposing wall surfaces.

    摘要翻译： 一种张力杆，其优选的形式包括一个外管和一个伸缩装置的内管。 外管具有可与外管的内表面接合以将其保持在适当位置的膨胀接头结构。 弹簧杆 - 楔形杆结构具有楔形部分，其具有从其延伸的螺纹杆，以穿过保持在膨胀杆结构中的螺母。 弹簧杆 - 楔形杆结构具有延伸穿过螺旋弹簧的杆，并且弹簧保持器固定到杆和内管。 内管的扭转使得楔形部分实现膨胀接头结构固定在外管中，并且螺旋弹簧提供张力以将拉杆安装在一对相对的壁表面之间。

    Tension Rod
    4.
    发明申请
    Tension Rod 有权
    拉杆

    公开(公告)号：US20120285914A1

    公开(公告)日：2012-11-15

    申请号：US13068354

    申请日：2011-05-09

    申请人： John R. Carney

    发明人： John R. Carney

    IPC分类号： F16M13/00

    CPC分类号： A47H1/022 ,  Y10T403/32501 ,  Y10T403/5726

    摘要： A tension rod comprising in its preferred form an outer tube and an inner tube in a telescoping arrangement. The outer tube has an expansion joint structure which can engage the inner surface of the outer tube to hold it in place. A spring stem-wedge-rod structure has a wedge portion with a threaded rod extending therefrom for being threaded through a nut held in the expansion rod structure. The spring stem-wedge-rod structure has a stem extending through a coil spring, and a spring retainer is fixed both to the stem and to the inner tube. Twisting of the inner tube causes the wedge portion to effect the expansion joint structure to be fixed in the outer tube, and the coil spring provides the tension to mount the tension rod between a pair of opposing wall surfaces.

    摘要翻译： 一种张力杆，其优选的形式包括一个外管和一个伸缩装置的内管。 外管具有可与外管的内表面接合以将其保持在适当位置的膨胀接头结构。 弹簧杆 - 楔形杆结构具有楔形部分，其具有从其延伸的螺纹杆，以穿过保持在膨胀杆结构中的螺母。 弹簧杆 - 楔形杆结构具有延伸穿过螺旋弹簧的杆，并且弹簧保持器固定到杆和内管。 内管的扭转使得楔形部分实现膨胀接头结构固定在外管中，并且螺旋弹簧提供张力以将拉杆安装在一对相对的壁表面之间。

    SHOWER CADDY CLIP AND SLEEVE
    5.
    发明申请
    SHOWER CADDY CLIP AND SLEEVE 失效
    淋浴CADDY夹子和套筒

    公开(公告)号：US20120159748A1

    公开(公告)日：2012-06-28

    申请号：US13328606

    申请日：2011-12-16

    申请人： John R. Carney

    发明人： John R. Carney

    IPC分类号： F16B2/20

    CPC分类号： A47K3/281 ,  F16B21/071 ,  Y10T24/44017 ,  Y10T24/44778 ,  Y10T24/44897

    摘要： A retaining device for retaining a shower caddy or other item on a shower arm or other elongated member includes a clip structure for partially surrounding the shower arm or elongated member and having retaining arms extending therefrom and a plastic sleeve structure having receptacles for receiving the retaining arms to hold the sleeve structure on the clip structure, and a shower-arm engaging portion or elongated member engaging portion for engaging the shower arm or elgongated member to render the shower caddy or other item immobile on the shower arm or elongated member.

    摘要翻译： 用于将淋浴器或其他物品保持在淋浴臂或其它细长构件上的保持装置包括用于部分地围绕淋浴器臂或细长构件并具有从其延伸的保持臂的夹子结构以及具有容纳保持臂的容器的塑料套管结构 将套筒结构保持在夹子结构上，以及用于与淋浴臂或多个部件啮合的淋浴臂接合部分或细长构件接合部分，以使淋浴器或其它物品不可移动到淋浴臂或细长构件上。

    Epothilone derivatives and methods for making and using the same
    7.
    发明授权
    Epothilone derivatives and methods for making and using the same 有权
    埃坡霉素衍生物及其制备和使用方法

    公开(公告)号：US07176235B2

    公开(公告)日：2007-02-13

    申请号：US10845467

    申请日：2004-05-12

    申请人： Gary Ashley ,  John R. Carney ,  Brian Metcalf

    发明人： Gary Ashley ,  John R. Carney ,  Brian Metcalf

    IPC分类号： A61K31/335 ,  C07D225/04 ,  C07D491/00 ,  C07D225/02

    CPC分类号： C07D405/06 ,  C07D313/00 ,  C07D413/06 ,  C07D417/06 ,  C07D491/04 ,  C12N1/20 ,  C12N9/00 ,  C12N15/52 ,  C12N15/74 ,  C12P17/16 ,  C12P17/181 ,  C12R1/01

    摘要： This invention relates to compounds of formula (I) and to pharmaceutically acceptable salts and solvates thereof, wherein R1, R2, R3, R4, R5, W, X, Y, and Ar are as defined herein. Compounds of formula (I) are useful in the treatment of diseases or conditions characterized by cellular hyperproliferation. This invention also relates to means for the preparation of compounds of formula (I); formulations containing compounds of formula (I); and methods for the use of said compounds and formulations in the treatment of a disease or condition characterized by cellular hyperproliferation, including cancer.

    摘要翻译： 本发明涉及式（I）化合物及其药用盐和溶剂合物，其中R 1，R 2，R 3， R 4，R 5，W，X，Y和Ar如本文所定义。 式（I）化合物可用于治疗以细胞过度增殖为特征的疾病或病症。 本发明还涉及制备式（I）化合物的方法; 含有式（I）化合物的制剂; 以及在治疗以细胞过度增殖为特征的疾病或病症（包括癌症）中使用所述化合物和制剂的方法。

    Shower caddy clip and sleeve
    8.
    发明授权
    Shower caddy clip and sleeve 失效
    淋浴花洒夹子和袖子

    公开(公告)号：US08769781B2

    公开(公告)日：2014-07-08

    申请号：US13328606

    申请日：2011-12-16

    申请人： John R. Carney

    发明人： John R. Carney

    IPC分类号： A44B99/00 ,  F16B2/20

    CPC分类号： A47K3/281 ,  F16B21/071 ,  Y10T24/44017 ,  Y10T24/44778 ,  Y10T24/44897

    摘要： A retaining device for retaining a shower caddy or other item on a shower arm or other elongated member includes a clip structure for partially surrounding the shower arm or elongated member and having retaining arms extending therefrom and a plastic sleeve structure having receptacles for receiving the retaining arms to hold the sleeve structure on the clip structure, and a shower-arm engaging portion or elongated member engaging portion for engaging the shower arm or elongated member to render the shower caddy or other item immobile on the shower arm or elongated member.

    摘要翻译： 用于将淋浴器或其他物品保持在淋浴臂或其它细长构件上的保持装置包括用于部分地围绕淋浴器臂或细长构件并具有从其延伸的保持臂的夹子结构以及具有容纳保持臂的容器的塑料套管结构 将套筒结构保持在夹子结构上，以及用于接合淋浴臂或细长构件的淋浴臂接合部分或细长构件接合部分，以使淋浴盆或其它物品在淋浴臂或细长构件上不动。