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公开(公告)号:US20120046317A1
公开(公告)日:2012-02-23
申请号:US13318740
申请日:2010-05-06
申请人: Chaitanya Dutt , Vijay Chauthaiwale , Ramesh Chandra Gupta , Manish Patel , Jignesh Kotecha , Sachin Latad , Jaya Abraham , Sanjay Srivastava , Milin Rode , Shailesh Deshpande , Anita Chaudhary , Amit Kumar Kesarwani
发明人: Chaitanya Dutt , Vijay Chauthaiwale , Ramesh Chandra Gupta , Manish Patel , Jignesh Kotecha , Sachin Latad , Jaya Abraham , Sanjay Srivastava , Milin Rode , Shailesh Deshpande , Anita Chaudhary , Amit Kumar Kesarwani
IPC分类号: A61K31/4535 , C07D213/54 , C07D211/34 , C07D409/02 , A61K31/4436 , A61K31/444 , A61K31/4439 , A61K31/435 , A61K31/445 , A61P25/00 , A61P9/12 , A61P9/04 , A61P27/02 , A61P9/10 , A61P25/28 , A61P13/12 , A61P17/00 , C07D409/14
CPC分类号: C07D409/06 , C07D211/56 , C07D211/60 , C07D401/04 , C07D401/14 , C07D405/14 , C07D409/14 , C07D417/04
摘要: The present invention relates to a new class of heterocyclic compounds and pharmaceutically acceptable salts thereof, process for preparing the same, pharmaceutical composition containing these compounds and to their use in treatment of diseases caused due to formation and accumulation of AGEs (Advanced Glycation end products). The compounds of the present invention are useful for the treatment of diabetic and aging-related complications caused by formation and accumulation of AGEs, such as neuropathy, nephropathy, microangiopathy, retinopathy, hypertension, heart failure, atherosclerosis, Alzheimer's disease & dermatological disorders.
摘要翻译: 本发明涉及一类新的杂环化合物及其药学上可接受的盐,其制备方法,含有这些化合物的药物组合物及其用于治疗由于AGEs的形成和积累引起的疾病(高级糖化终产物) 。 本发明的化合物可用于治疗由AGEs的形成和积累引起的糖尿病和老化相关并发症,例如神经病,肾病,微血管病变,视网膜病变,高血压,心力衰竭,动脉粥样硬化,阿尔茨海默病和皮肤病。