公开(公告)号：US20100297270A1

公开(公告)日：2010-11-25

申请号：US12602457

申请日：2008-05-28

申请人： Chan-Woong Park ,  Myeong Hoon Yeom ,  Nam Hoon Cho ,  Sang Jun Lee ,  Sang Min Lee ,  Jin Young Lee ,  Hee Yong Jeon ,  Young-Myeong Kim ,  Chun-Ki kim ,  Young Deuk Choi

发明人： Chan-Woong Park ,  Myeong Hoon Yeom ,  Nam Hoon Cho ,  Sang Jun Lee ,  Sang Min Lee ,  Jin Young Lee ,  Hee Yong Jeon ,  Young-Myeong Kim ,  Chun-Ki kim ,  Young Deuk Choi

IPC分类号： A61K36/258 ,  A61K8/97 ,  A61Q19/08 ,  A61Q19/02 ,  A61Q19/00 ,  A61P9/00 ,  A61P9/10 ,  A61P15/10 ,  A61P15/00

CPC分类号： A61K36/258 ,  A23L33/105 ,  A23V2002/00 ,  A61K9/0019 ,  A61K9/0095 ,  A61K9/1652 ,  A61K9/2018 ,  A61K9/4875 ,  A61K31/198 ,  A23V2250/2124 ,  A23V2200/318 ,  A23V2200/326 ,  A61K2300/00

摘要： A composition containing ginseng berry extract as active ingredient is for facilitation of blood circulation, for prevention of vascular aging, for treatment of vascular inflammation, for facilitation of angiogenesis, for treatment of ischemic heart disease, for improvement and treatment of local blood circulation insufficiency, for improvement of skin beauty and for improvement of male sexual function. More particularly, the compositions containing ginseng berry extract as active ingredient facilitate nitric oxide (NO) generation in endothelial cells, improve viability of endothelial cells, and facilitate angiogenesis through increased mobility of endothelial cells and vascular tube formation; provide antioxidative effect, facilitate biosynthesis of collagen, provide skin aging inhibiting and wrinkle improving effects through inhibition of MMP-1, provide skin whitening effect through inhibition of melanin synthesis, and provide skin moisturizing effect; and improve male sexual function through relaxation of the corpus cavernosum and enhancement of penial erection, and, as used in combination with l-arginine, which is a substrate of nitric oxide synthase, provide synergically enhanced NO generation.

摘要翻译： 含有人参浆果提取物作为活性成分的组合物用于促进血液循环，用于预防血管衰老，治疗血管发炎，促进血管生成，治疗缺血性心脏病，改善和治疗局部血液循环功能不全， 用于改善皮肤美容和改善男性性功能。 更特别地，含有人参浆果提取物作为活性成分的组合物促进内皮细胞中的一氧化氮（NO）产生，改善内皮细胞的活力，并通过增加内皮细胞的活动性和血管形成促进血管生成; 提供抗氧化作用，促进胶原蛋白的生物合成，通过抑制MMP-1提供皮肤衰老抑制和皱纹改善作用，通过抑制黑色素合成提供皮肤美白效果，并提供皮肤保湿效果; 并通过放松海绵体和增强阴茎勃起来改善男性的性功能，并且与作为一氧化氮合成酶底物的1-精氨酸组合使用可提供协同增强的NO产生。

公开(公告)号：US09314493B2

公开(公告)日：2016-04-19

申请号：US13565224

申请日：2012-08-02

申请人： Chan-Woong Park ,  Myeong Hoon Yeom ,  Nam Hoon Cho ,  Sang Jun Lee ,  Sang Min Lee ,  Jin Young Lee ,  HeeYong Jeon ,  Young-Myeong Kim ,  Chun-Ki Kim ,  Young Deuk Choi

发明人： Chan-Woong Park ,  Myeong Hoon Yeom ,  Nam Hoon Cho ,  Sang Jun Lee ,  Sang Min Lee ,  Jin Young Lee ,  HeeYong Jeon ,  Young-Myeong Kim ,  Chun-Ki Kim ,  Young Deuk Choi

IPC分类号： A61K36/258 ,  A61Q19/08 ,  A61K8/97 ,  A61K31/198 ,  A61Q19/02

CPC分类号： A61K36/258 ,  A61K8/97 ,  A61K31/198 ,  A61Q19/02 ,  A61Q19/08 ,  A61K2300/00

摘要： The present disclosure discloses a method for treating vascular inflammation, improving skin beauty and improving male sexual function of a subject by administering a ginseng berry extract to the subject.

摘要翻译： 本公开公开了一种通过向受试者施用人参浆果提取物来治疗血管炎症，改善皮肤美容并改善受试者的男性性功能的方法。

公开(公告)号：US08652542B2

公开(公告)日：2014-02-18

申请号：US13131007

申请日：2009-11-26

申请人： Chan-Woong Park ,  Dae Bang Seo ,  Hee Young Jeon ,  Sang Min Lee ,  Wan Gi Kim ,  Sang Jun Lee ,  Young-Myeong Kim ,  Chun-Ki Kim

发明人： Chan-Woong Park ,  Dae Bang Seo ,  Hee Young Jeon ,  Sang Min Lee ,  Wan Gi Kim ,  Sang Jun Lee ,  Young-Myeong Kim ,  Chun-Ki Kim

IPC分类号： A61K36/258

CPC分类号： A61K36/258

摘要： A composition according to the present invention is a composition containing extract of Panax ginseng C.A. Meyer fruit as an active ingredient for preventing or treating artherosclerosis. The extract is confirmed to effectively suppress lesions or generation of a vascular inflammation factor caused by artherosclerosis. Thus, the composition is suitable for use as an active ingredient of the composition for preventing or treating artherosclerosis.

摘要翻译： 根据本发明的组合物是含有人参C.A.的提取物的组合物。 梅耶果作为预防或治疗动脉粥样硬化的有效成分。 证实提取物能有效地抑制由动脉粥样硬化引起的损伤或血管炎症因子的产生。 因此，该组合物适合用作预防或治疗动脉粥样硬化的组合物的活性成分。

公开(公告)号：US20110268824A1

公开(公告)日：2011-11-03

申请号：US13131007

申请日：2009-11-26

申请人： Chan-Woong Park ,  Dae Bang Seo ,  Hee Young Jeon ,  Sang Min Lee ,  Wan Gi Kim ,  Sang Jun Lee ,  Young-Myeong Kim ,  Chun-ki Kim

发明人： Chan-Woong Park ,  Dae Bang Seo ,  Hee Young Jeon ,  Sang Min Lee ,  Wan Gi Kim ,  Sang Jun Lee ,  Young-Myeong Kim ,  Chun-ki Kim

IPC分类号： A61K36/258 ,  A61P9/10

CPC分类号： A61K36/258

摘要： A composition according to the present invention is a composition containing extract of Panax ginseng C.A. Meyer fruit as an active ingredient for preventing or treating artherosclerosis. The extract is confirmed to effectively suppress lesions or generation of a vascular inflammation factor caused by artherosclerosis. Thus, the composition is suitable for use as an active ingredient of the composition for preventing or treating artherosclerosis.

摘要翻译： 根据本发明的组合物是含有人参C.A.的提取物的组合物。 梅耶果作为预防或治疗动脉粥样硬化的有效成分。 证实提取物能有效地抑制由动脉粥样硬化引起的损伤或血管炎症因子的产生。 因此，该组合物适合用作预防或治疗动脉粥样硬化的组合物的活性成分。

公开(公告)号：US20170278625A1

公开(公告)日：2017-09-28

申请号：US15618147

申请日：2017-06-09

申请人： Chan-Woong Park

发明人： Chan-Woong Park

IPC分类号： H01F27/33 ,  H01F27/40 ,  H01F27/38 ,  H02M1/44 ,  H02M3/28

CPC分类号： H01F27/33 ,  H01F27/38 ,  H01F27/40 ,  H01F2027/408 ,  H02M1/44 ,  H02M3/28

摘要： A magnetic energy-transfer element including: a core of the magnetic energy-transfer element; an input winding wound around the core of the magnetic energy-transfer element, a first terminal of the input winding being connected to a first terminal of the input filter capacitor, a second terminal of the input winding being connected to a first terminal of the switching element; an output winding wound around the core of the magnetic energy-transfer element to take out energy; and a cancellation winding wound around the core of the magnetic energy-transfer element.

公开(公告)号：US20130242452A1

公开(公告)日：2013-09-19

申请号：US13883466

申请日：2011-11-07

申请人： Chan-Woong Park

发明人： Chan-Woong Park

IPC分类号： H01F27/33

CPC分类号： H01F27/33 ,  H01F27/38 ,  H01F27/40 ,  H01F2027/408 ,  H02M1/44 ,  H02M3/28

摘要： The present invention relates to a transmitter and power supply which suffers little EMI deviation and provides adequate margin even in volume production, and which can cut the unit price of transformers and economize on the costs of EMI filters, by cancelling out and eliminating the conducted noise or the conducted noise and radiated noise caused by capacitive coupling between the windings of a transformer, the transformer being of an uncomplicated construction which is good in terms of production.

摘要翻译： 本发明涉及一种发射器和电源，其具有很小的EMI偏差，并且即使在批量生产中也提供足够的裕度，并且可以通过消除和消除传导噪声来降低变压器的单价并节省EMI滤波器的成本 或由变压器的绕组之间的电容耦合引起的传导噪声和辐射噪声，变压器是一种在生产方面良好的不复杂的结构。

公开(公告)号：US09704641B2

公开(公告)日：2017-07-11

申请号：US13883466

申请日：2011-11-07

申请人： Chan-Woong Park

发明人： Chan-Woong Park

IPC分类号： H01F27/28 ,  H01F27/34 ,  H01F27/33 ,  H01F27/40 ,  H02M1/44 ,  H02M3/28 ,  H01F27/38

CPC分类号： H01F27/33 ,  H01F27/38 ,  H01F27/40 ,  H01F2027/408 ,  H02M1/44 ,  H02M3/28

摘要： The present invention relates to a transmitter and power supply which suffers little EMI deviation and provides adequate margin even in volume production, and which can cut the unit price of transformers and economize on the costs of EMI filters, by cancelling out and eliminating the conducted noise or the conducted noise and radiated noise caused by capacitive coupling between the windings of a transformer, the transformer being of an uncomplicated construction which is good in terms of production.

公开(公告)号：US08785392B2

公开(公告)日：2014-07-22

申请号：US13142818

申请日：2010-04-13

申请人： Young Woo Park ,  Kiwon Jo ,  Donghee Lee ,  Jung Yu ,  Ji Hyun Park ,  Chan-Woong Park ,  Eun Jin Kim ,  Yun Jung Park

发明人： Young Woo Park ,  Kiwon Jo ,  Donghee Lee ,  Jung Yu ,  Ji Hyun Park ,  Chan-Woong Park ,  Eun Jin Kim ,  Yun Jung Park

IPC分类号： A61K38/16 ,  A61K38/17 ,  A61K39/00 ,  C07K14/435 ,  C07K14/705 ,  C07K14/735 ,  C07K16/28 ,  C07K16/00 ,  C07K14/475

CPC分类号： C07K16/00 ,  C07K14/435 ,  C07K14/475 ,  C07K2319/30 ,  Y10S424/809 ,  Y10S530/866

摘要： A recombinant expression vector, comprising extracellular soluble domain genes of DLK1 and IgG antibody Fc domain genes, is constructed, and DLK1-Fc fusion protein is expressed and purified at 293E cell. The invention confirmed the efficacy as a drug for inhibiting cancer metastasis by confirming markedly reduced migration of cancer cells by DLK1-Fc fusion protein and also computing pharmacokinetic parameters. DLK1-Fc fusion protein has relatively higher stability than non-fusion protein, significantly reduces migration of various cancer cell lines, and provides superior cancer metastasis inhibition effect even at small concentration. Accordingly, DLK1-Fc fusion protein can be used efficaciously as an effective ingredient of a composition for inhibiting cancer metastasis.

摘要翻译： 构建了包含DLK1和IgG抗体Fc结构域基因的细胞外可溶性域基因的重组表达载体，并且在293E细胞上表达和纯化DLK1-Fc融合蛋白。 本发明通过确认DLK1-Fc融合蛋白对癌细胞的迁移显着减少并且还计算药代动力学参数，证实了作为抑制癌症转移的药物的功效。 DLK1-Fc融合蛋白具有比非融合蛋白更高的稳定性，显着降低各种癌细胞系的迁移，即使在小浓度下也能提供优异的癌转移抑制作用。 因此，DLK1-Fc融合蛋白可以有效地用作抑制癌症转移的组合物的有效成分。

公开(公告)号：US20130202592A1

公开(公告)日：2013-08-08

申请号：US13142818

申请日：2010-04-13

申请人： Young Woo Park ,  Kiwon Jo ,  Donghee Lee ,  Jung Yu ,  Ji Hyun Park ,  Chan-Woong Park ,  Eun Jin Kim ,  Yun Jung Park

发明人： Young Woo Park ,  Kiwon Jo ,  Donghee Lee ,  Jung Yu ,  Ji Hyun Park ,  Chan-Woong Park ,  Eun Jin Kim ,  Yun Jung Park

IPC分类号： C07K16/00 ,  C07K14/435

CPC分类号： C07K16/00 ,  C07K14/435 ,  C07K14/475 ,  C07K2319/30 ,  Y10S424/809 ,  Y10S530/866

摘要： A recombinant expression vector, comprising extracellular soluble domain genes of DLK1 and IgG antibody Fc domain genes, is constructed, and DLK1-Fc fusion protein is expressed and purified at 293E cell. The invention confirmed the efficacy as a drug for inhibiting cancer metastasis by confirming markedly reduced migration of cancer cells by DLK1-Fc fusion protein and also computing pharmacokinetic parameters. DLK1-Fc fusion protein has relatively higher stability than non-fusion protein, significantly reduces migration of various cancer cell lines, and provides superior cancer metastasis inhibition effect even at small concentration. Accordingly, DLK1-Fc fusion protein can be used efficaciously as an effective ingredient of a composition for inhibiting cancer metastasis.

摘要翻译： 构建了包含DLK1和IgG抗体Fc结构域基因的细胞外可溶性域基因的重组表达载体，并且在293E细胞上表达和纯化DLK1-Fc融合蛋白。 本发明通过确认DLK1-Fc融合蛋白对癌细胞的迁移显着减少并且还计算药代动力学参数，证实了作为抑制癌症转移的药物的功效。 DLK1-Fc融合蛋白具有比非融合蛋白更高的稳定性，显着降低各种癌细胞系的迁移，即使在小浓度下也能提供优异的癌转移抑制作用。 因此，DLK1-Fc融合蛋白可以有效地用作抑制癌症转移的组合物的有效成分。