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公开(公告)号：US10111915B1
公开(公告)日：2018-10-30
申请号：US15815134
申请日：2017-11-16
发明人： Yun-Fei Ko , Jan Martel , Tsung-Ru Wu , Chih-Jung Chang , Chuan-Sheng Lin , Jian-Ching Liau , Wei-Chang Wang , Chen-Yaw Chiu , Chia-Chen Lu , David Marcelo Ojcius , Hsin-Chih Lai , John D. Young
IPC分类号： A61K49/00 , A61K48/00 , A01N63/00 , A61K35/741 , A61K39/00
摘要： The present invention describes a method to reduce blood aspartate transaminase level, liver weight, hepatic lipid accumulation and hepatocyte hypertrophy by administering the probiotic bacterium Parabacteroides goldsteinii to a subject showing signs of fatty liver disease. This probiotic bacterium can therefore be used to treat fatty liver disease.
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2.发明授权公开(公告)号：US10086019B1
公开(公告)日：2018-10-02
申请号：US15791010
申请日：2017-10-23
发明人： Yun-Fei Ko , Jan Martel , Tsung-Ru Wu , Chih-Jung Chang , Chuan-Sheng Lin , Jian-Ching Liau , Wei-Chang Wang , Chen-Yaw Chiu , Chia-Chen Lu , David Marcelo Ojcius , Hsin-Chih Lai , John D. Young
摘要： The present invention provides a method to reduce insulin resistance and improve glucose tolerance by administering the probiotic bacterium Parabacteroides goldsteinii. This probiotic bacterium can therefore be used to treat insulin resistance, metabolic syndrome, and type 2 diabetes.
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公开(公告)号：US09828442B2
公开(公告)日：2017-11-28
申请号：US14855143
申请日：2015-09-15
发明人： Yun-Fei Ko , Jan Martel , Jian-Ching Liau , I-Te Chang , Chien-Sheng Lee , Wei-Chang Wang , Chen-Yaw Chiu , Chih-Jung Chang , Chuan-Sheng Lin , Tsung-Ru Wu , Chia-Chen Lu , David Marcelo Ojcius , Hsin-Chih Lai , Ding-E Young
IPC分类号： A61K36/00 , C08B37/00 , A61K36/062
CPC分类号： C08B37/0003 , A61K36/062 , A61K2236/00
摘要： The present invention provides a method to prepare polysaccharides from Hirsutella sinensis. The prepared polysaccharides can reduce hyperglycemia and insulin resistance, and can therefore be used to prevent and treat type 2 diabetes and related conditions.
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4.发明申请METHOD TO PREPARE GANODERMA LUCIDUM POLYSACCHARIDES POSSESSING PROTECTIVE ACTIVITIES ON FATTY LIVER DISEASE 有权制备甘油酸多糖在脂肪肝疾病上发挥保护作用的方法公开(公告)号：US20170028003A1
公开(公告)日：2017-02-02
申请号：US14863130
申请日：2015-09-23
发明人： Yun-Fei Ko , Jan Martel , Jian-Ching Liau , I-Te Chang , Wei-Ting Jian , Mei-Feng Lin , Chia-Jen Yang , Chen-Yaw Chiu , Chih-Jung Chang , Chuan-Sheng Lin , Tsung-Ru Wu , Chia-Chen Lu , David Marcelo Ojcius , Hsin-Chih Lai , Ding-E Young
IPC分类号： A61K36/074 , A61K31/715
CPC分类号： A61K36/074 , A61K31/715 , A61K2236/00 , C08B37/0003
摘要： The present invention provides a method to prepare polysaccharides from Ganoderma lucidum. The prepared polysaccharides can reduce liver weight and liver lipid content in humans and animals. The prepared polysaccharides can therefore be used to prevent and treat fatty liver disease.
摘要翻译： 本发明提供了一种从灵芝制备多糖的方法。 制备的多糖可以降低人体和动物的肝脏重量和肝脏脂质含量。 因此，制备的多糖可用于预防和治疗脂肪肝疾病。
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5.发明申请公开(公告)号：US20160361341A1
公开(公告)日：2016-12-15
申请号：US14855143
申请日：2015-09-15
发明人： Yun-Fei Ko , Jan Martel , Jian-Ching Liau , I-Te Chang , Chien-Sheng Lee , Wei-Chang Wang , Chen-Yaw Chiu , Chih-Jung Chang , Chuan-Sheng Lin , Tsung-Ru Wu , Chia-Chen Lu , David Marcelo Ojcius , Hsin-Chih Lai , Ding-E Young
IPC分类号： A61K31/715 , C08B37/00 , A61K36/062
CPC分类号： C08B37/0003 , A61K36/062 , A61K2236/00
摘要： The present invention provides a method to prepare polysaccharides from Hirsutella sinensis. The prepared polysaccharides can reduce hyperglycemia and insulin resistance, and can therefore be used to prevent and treat type 2 diabetes and related conditions.
摘要翻译： 本发明提供了一种制备中华百草枯多糖的方法。 制备的多糖可以降低高血糖和胰岛素抵抗，因此可用于预防和治疗2型糖尿病及相关病症。
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公开(公告)号：US09782431B2
公开(公告)日：2017-10-10
申请号：US14856397
申请日：2015-09-16
发明人： Yun-Fei Ko , Jan Martel , Jian-Ching Liau , I-Te Chang , Chien-Sheng Lee , Wei-Chang Wang , Chen-Yaw Chiu , Chih-Jung Chang , Chuan-Sheng Lin , Tsung-Ru Wu , Chia-Chen Lu , David Marcelo Ojcius , Hsin-Chih Lai , Ding-E Young
IPC分类号： A61K31/736 , A61K36/062 , C08B37/00
CPC分类号： A61K31/736 , A61K36/062 , A61K45/06 , A61K2236/53 , C08B37/0003 , C08B37/0087
摘要： The present invention provides a method to prepare polysaccharides from Hirsutella sinensis. The prepared polysaccharides reduce body weight and fat accumulation in laboratory animals, and can therefore be used to prevent and treat obesity.
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公开(公告)号：US09757409B2
公开(公告)日：2017-09-12
申请号：US14855055
申请日：2015-09-15
发明人： Yun-Fei Ko , Jan Martel , Jian-Ching Liau , I-Te Chang , Wei-Ting Jian , Mei-Feng Lin , Chia-Jen Yang , Chen-Yaw Chiu , Chih-Jung Chang , Chuan-Sheng Lin , Tsung-Ru Wu , Chia-Chen Lu , David Marcelo Ojcius , Hsin-Chih Lai , John D. Young
IPC分类号： A61K31/715 , A61K36/074 , C08B37/00
CPC分类号： A61K31/715 , A61K36/074 , A61K2236/00 , C08B37/0003
摘要： The present invention provides a method to prepare polysaccharides from Ganoderma lucidum. The prepared polysaccharides can reduce hyperglycemia and improve insulin sensitivity in humans and animals, and can therefore be used to prevent and treat type 2 diabetes.
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8.发明申请METHOD TO PREPARE HIRSUTELLA SINENSIS POLYSACCHARIDES POSSESSING PROTECTIVE ACTIVITIES ON FATTY LIVER DISEASE 有权制备防治脂肪肝疾病的保护性活动的高分子多糖的方法公开(公告)号：US20160361370A1
公开(公告)日：2016-12-15
申请号：US14856425
申请日：2015-09-16
发明人： Yun-Fei Ko , Jan Martel , Jian-Ching Liau , I-Te Chang , Chien-Sheng Lee , Wei-Chang Wang , Chen-Yaw Chiu , Chih-Jung Chang , Chuan-Sheng Lin , Tsung-Ru Wu , Chia-Chen Lu , David Marcelo Ojcius , Hsin-Chih Lai , Ding-E Young
IPC分类号： A61K36/06 , A61K31/7008 , A61K31/7004
CPC分类号： A61K36/06 , A61K31/7004 , A61K31/7008 , A61K31/715 , A61K2300/00
摘要： The present invention provides a method to prepare polysaccharides from Hirsutella sinensis. The prepared polysaccharides can reduce liver size, weight and the number and size of liver lipid vacuoles, as well as serum triglycerides and serum aspartate aminotransferase levels in humans and animals. The prepared polysaccharides can therefore be used to prevent and treat fatty liver disease.
摘要翻译： 本发明提供了一种从中华百草枯制备多糖的方法。 制备的多糖可以减少人体和动物的肝脏大小，体重和肝脂质空泡的数量和大小，以及血清甘油三酯和血清天冬氨酸氨基转移酶水平。 因此，制备的多糖可用于预防和治疗脂肪肝疾病。
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9.发明申请公开(公告)号：US20190183960A1
公开(公告)日：2019-06-20
申请号：US15906353
申请日：2018-02-27
发明人： Yun-Fei Ko , Jan Martel , Jian-Ching Liau , Chen-Yaw Chiu , Chuan-Sheng Lin , Luis Dominick B. Antig , Pei-Wen Hsieh , Yu-Li Chen , Chih-Jung Chang , Tsung-Ru Wu , David Marcelo Ojcius , Chia-Chen Lu , Hsin-Chih Lai , John D. Young
摘要： The present invention provides a method to treat asthma and airway allergy by administering the dipeptide cyclo tyrosine-valine or a related cyclodipeptide compound to a subject in need thereof. Cyclo tyrosine-valine or the related cyclodipeptide compound reduces Th2 cell activation, airway hyperresponsiveness, accumulation of immune cells in bronchoalveolar fluid, and allergen-specific antibody production in an animal or human subject. The compound can therefore be used to treat asthma and airway allergy.
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公开(公告)号：US09782447B2
公开(公告)日：2017-10-10
申请号：US14856425
申请日：2015-09-16
发明人： Yun-Fei Ko , Jan Martel , Jian-Ching Liau , I-Te Chang , Chien-Sheng Lee , Wei-Chang Wang , Chen-Yaw Chiu , Chih-Jung Chang , Chuan-Sheng Lin , Tsung-Ru Wu , Chia-Chen Lu , David Marcelo Ojcius , Hsin-Chih Lai , Ding-E Young
IPC分类号： A61K36/06 , A61K31/715 , A61K31/7004 , A61K31/7008
CPC分类号： A61K36/06 , A61K31/7004 , A61K31/7008 , A61K31/715 , A61K2300/00
摘要： The present invention provides a method to prepare polysaccharides from Hirsutella sinensis. The prepared polysaccharides can reduce liver size, weight and the number and size of liver lipid vacuoles, as well as serum triglycerides and serum aspartate aminotransferase levels in humans and animals. The prepared polysaccharides can therefore be used to prevent and treat fatty liver disease.
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