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公开(公告)号：US20100008866A1
公开(公告)日：2010-01-14
申请号：US12436587
申请日：2009-05-06
IPC分类号： A61K9/12 , C12N5/02 , G01N33/566 , A61K31/519 , A61K31/522 , C07D513/04 , C07D473/04 , C07D495/04 , A61P11/00 , A61P29/00 , A61P1/00 , A61P7/12
CPC分类号： C07D473/30 , C07D471/04 , C07D495/04 , C07D513/04
摘要： Cis-cyclohexyl substituted pyrimidinone derivatives are provided, of the Formula: wherein variables are as described herein. Such compounds are ligands that may be used to modulate specific receptor activity in vivo or in vitro, and are particularly useful in the treatment of conditions associated with pathological receptor activation in humans, domesticated companion animals and livestock animals. Pharmaceutical compositions and methods for using such compounds to treat such disorders are provided, as are methods for using such ligands for receptor localization studies.
摘要翻译： 提供顺式 - 环己基取代的嘧啶酮衍生物，其具有如下所述的变体： 这些化合物是可用于在体内或体外调节特异性受体活性的配体，并且特别可用于治疗与人类，驯养伴侣动物和家畜中的病理受体激活相关的病症。 还提供了使用这些化合物治疗这种病症的药物组合物和方法，以及使用这些配体进行受体定位研究的方法。
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公开(公告)号：US20080090845A1
公开(公告)日：2008-04-17
申请号：US11895266
申请日：2007-08-22
IPC分类号： A61K31/522 , A61K31/519 , A61P11/06 , A61P11/14 , A61P13/00 , A61P29/00 , A61P5/00 , C07D409/02 , C07D417/04 , C07D471/04 , C07D473/30 , C07K14/435 , C12N5/06
CPC分类号： C07D473/30 , C07D471/04 , C07D495/04 , C07D513/04
摘要： Haloalkyl-substituted pyrimidinone derivatives are provided, of the Formula: wherein variables are as described herein. Such compounds are ligands that may be used to modulate specific receptor activity in vivo or in vitro, and are particularly useful in the treatment of conditions associated with pathological receptor activation in humans, domesticated companion animals and livestock animals. Pharmaceutical compositions and methods for using such compounds to treat such disorders are provided, as are methods for using such ligands for receptor localization studies.
摘要翻译： 提供了下式的卤代烷基取代的嘧啶酮衍生物：其中变量如本文所述。 这些化合物是可用于在体内或体外调节特异性受体活性的配体，并且特别可用于治疗与人类，驯养伴侣动物和家畜中的病理受体激活相关的病症。 还提供了使用这些化合物治疗这种病症的药物组合物和方法，以及使用这些配体进行受体定位研究的方法。
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公开(公告)号：US08334382B2
公开(公告)日：2012-12-18
申请号：US12705964
申请日：2010-02-15
IPC分类号： C07D403/14 , C07D401/14 , A61K31/506 , A61K31/53 , A61P19/02
CPC分类号： C07D405/14 , C07D239/42 , C07D239/48 , C07D401/12 , C07D401/14 , C07D403/14 , C07D409/14 , C07D413/14
摘要： Substituted biaryl piperazinyl-pyridine analogues are provided, of the Formula: wherein variables are as described herein. Such compounds are ligands that may be used to modulate specific receptor activity in vivo or in vitro, and are particularly useful in the treatment of conditions associated with pathological receptor activation in humans, domesticated companion animals and livestock animals. Pharmaceutical compositions and methods for using such compounds to treat such disorders are provided, as are methods for using such ligands for receptor localization studies.
摘要翻译： 提供了下式的取代的联芳基哌嗪基 - 吡啶类似物：其中变量如本文所述。 这些化合物是可用于在体内或体外调节特异性受体活性的配体，并且特别可用于治疗与人类，驯养伴侣动物和家畜中的病理受体激活相关的病症。 还提供了使用这些化合物治疗这种病症的药物组合物和方法，以及使用这些配体进行受体定位研究的方法。
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公开(公告)号：US20110003813A1
公开(公告)日：2011-01-06
申请号：US12705964
申请日：2010-02-15
IPC分类号： A61K31/5377 , G01N33/53 , C07D413/14 , C07D401/14 , A61K31/497 , A61K31/496 , A61P25/00
CPC分类号： C07D405/14 , C07D239/42 , C07D239/48 , C07D401/12 , C07D401/14 , C07D403/14 , C07D409/14 , C07D413/14
摘要： Substituted biaryl piperazinyl-pyridine analogues are provided, of the Formula: wherein variables are as described herein. Such compounds are ligands that may be used to modulate specific receptor activity in vivo or in vitro, and are particularly useful in the treatment of conditions associated with pathological receptor activation in humans, domesticated companion animals and livestock animals. Pharmaceutical compositions and methods for using such compounds to treat such disorders are provided, as are methods for using such ligands for receptor localization studies.
摘要翻译： 提供了下式的取代的联芳基哌嗪基 - 吡啶类似物：其中变量如本文所述。 这些化合物是可用于在体内或体外调节特异性受体活性的配体，并且特别可用于治疗与人类，驯养伴侣动物和家畜中的病理受体激活相关的病症。 还提供了使用这些化合物治疗这种病症的药物组合物和方法，以及使用这些配体进行受体定位研究的方法。
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![Aryl-Substituted Benzo[D]Isothiazol-3-Ylamine Analogues](/abs-image/US/2008/05/29/US20080125466A1/abs.jpg.150x150.jpg)
公开(公告)号：US20080125466A1
公开(公告)日：2008-05-29
申请号：US10564263
申请日：2004-07-09
申请人： Charles A. Blum , Xiaozhang Zheng
发明人： Charles A. Blum , Xiaozhang Zheng
IPC分类号： A61K31/4439 , C07D417/10 , A61P3/04 , A61P25/00 , A61P11/00
CPC分类号： C07D275/06 , C07D417/04
摘要： Aryl-substituted benzo[d]isothiazol-3-ylamine analogues) are provided, of the Formula: wherein variables are as described herein. Such compounds are ligands that may be used to modulate specific receptor activity in vivo or in vitro, and are particularly useful in the treatment of conditions associated with pathological receptor activation in humans, domesticated companion animals and livestock animals. Pharmaceutical compositions and methods for using such compounds to treat such disorders are provided, as are methods for using such ligands for receptor localization studies.
摘要翻译： 提供了芳基取代的苯并[d]异噻唑-3-基胺类似物），其中变量如本文所述。 这些化合物是可用于在体内或体外调节特异性受体活性的配体，并且特别可用于治疗与人类，驯养伴侣动物和家畜中的病理受体激活相关的病症。 还提供了使用这些化合物治疗这种病症的药物组合物和方法，以及使用这些配体进行受体定位研究的方法。
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6.发明授权Carboxylic acid, phosphate or phosphonate substituted quinazolin-4-ylamine analogues as capsaicin receptor modulators 失效羧酸，磷酸酯或膦酸酯取代的喹唑啉-4-基胺类似物作为辣椒素受体调节剂公开(公告)号：US07432275B2
公开(公告)日：2008-10-07
申请号：US10539031
申请日：2003-12-12
申请人： Rajagopal Bakthavatchalam , Charles A. Blum , Harry Brielmann , Timothy M. Caldwell , Stéphane DeLombaert , Kevin J. Hodgetts , Xiaozhang Zheng
发明人： Rajagopal Bakthavatchalam , Charles A. Blum , Harry Brielmann , Timothy M. Caldwell , Stéphane DeLombaert , Kevin J. Hodgetts , Xiaozhang Zheng
IPC分类号： A01N43/54 , A61K31/517 , C07D239/72
CPC分类号： C07D417/14 , C07D239/94 , C07D401/04 , C07D401/14 , C07D405/14 , C07D409/14 , C07D471/04 , C07D491/10 , C07F9/65128 , C07F9/65583 , C07F9/6561
摘要： Acid-substituted quinazolin-4-ylamine analogues are provided. Such compounds are ligands that may be used to modulate specific receptor activity in vivo or in vitro, and are particularly useful in the treatment of conditions associated with pathological receptor activation in humans, domesticated companion animals and livestock animals. Pharmaceutical compositions and methods for using them to treat such disorders are provided, as are methods for using such ligands for receptor localization studies.
摘要翻译： 提供了酸取代的喹唑啉-4-基胺类似物。 这些化合物是可用于在体内或体外调节特异性受体活性的配体，并且特别可用于治疗与人类，驯养伴侣动物和家畜中的病理受体激活相关的病症。 还提供了用于治疗这些病症的药物组合物和方法，以及使用这些配体进行受体定位研究的方法。
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7.发明授权Substituted (7-pyridyl-4-phenylamino-quinazolin-2-yl)-methanol analogues 失效取代的（7-吡啶基-4-苯基氨基 - 喹唑啉-2-基） - 甲醇类似物公开(公告)号：US07329664B2
公开(公告)日：2008-02-12
申请号：US10892741
申请日：2004-07-16
申请人： Rajagopal Bakthavatchalam , Charles A. Blum , Harry Brielmann , Stéphane De Lombaert , Xiaozhang Zheng
发明人： Rajagopal Bakthavatchalam , Charles A. Blum , Harry Brielmann , Stéphane De Lombaert , Xiaozhang Zheng
IPC分类号： A61K31/517 , A61K31/519 , C07D401/04 , C07D405/14 , C07D487/04
CPC分类号： C07D401/04 , C07D401/14 , C07D405/14
摘要： Substituted (7-pyridyl-4-phenylamino-quinazolin-2-yl)-methanol analogues are provided. Such compounds are ligands that may be used to modulate specific receptor activity in vivo or in vitro, and are particularly useful in the treatment of conditions associated with pathological receptor activation in humans, domesticated companion animals and livestock animals. Pharmaceutical compositions and methods for using them to treat such disorders are provided, as are methods for using such ligands for receptor localization studies
摘要翻译： 提供了取代的（7-吡啶基-4-苯基氨基 - 喹唑啉-2-基） - 甲醇类似物。 这些化合物是可用于在体内或体外调节特异性受体活性的配体，并且特别可用于治疗与人类，驯养伴侣动物和家畜中的病理受体激活相关的病症。 还提供了用于治疗这些病症的药物组合物和方法，以及使用这些配体进行受体定位研究的方法
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公开(公告)号：US07304059B2
公开(公告)日：2007-12-04
申请号：US11345926
申请日：2006-02-01
申请人： Rajagopal Bakthavatchalam , Charles A. Blum , Harry Brielmann , Timothy M. Caldwell , Stéphane De Lombaert , Kevin J. Hodgetts , Xiaozhang Zheng , Taeyoung Yoon
发明人： Rajagopal Bakthavatchalam , Charles A. Blum , Harry Brielmann , Timothy M. Caldwell , Stéphane De Lombaert , Kevin J. Hodgetts , Xiaozhang Zheng , Taeyoung Yoon
IPC分类号： C07D403/12 , C07D403/14 , A61K31/517
CPC分类号： C07D401/04 , C07D215/42 , C07D215/44 , C07D237/34 , C07D239/94 , C07D401/12 , C07D401/14 , C07D413/14 , C07D417/14 , C07D419/14 , C07D471/04
摘要： Substituted quinazolin-4-ylamine analogues are provided. Such compounds are ligands that may be used to modulate specific receptor activity in vivo or in vitro, and are particularly useful in the treatment of conditions associated with pathological receptor activation in humans, domesticated companion animals and livestock animals. Pharmaceutical compositions and methods for using them to treat such disorders are provided, as are methods for using such ligands for receptor localization studies.
摘要翻译： 提供了取代的喹唑啉-4-基胺类似物。 这些化合物是可用于在体内或体外调节特异性受体活性的配体，并且特别可用于治疗与人类，驯养伴侣动物和家畜中的病理受体激活相关的病症。 还提供了用于治疗这些病症的药物组合物和方法，以及使用这些配体进行受体定位研究的方法。
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9.发明申请Substituted (7-pyridyl-4-phenylamino-quinazolin-2-yl)-methanol analogues 审中-公开取代的（7-吡啶基-4-苯基氨基 - 喹唑啉-2-基） - 甲醇类似物公开(公告)号：US20080153857A1
公开(公告)日：2008-06-26
申请号：US11953858
申请日：2007-12-10
申请人： Rajagopal Bakthavatchalam , Charles A. Blum , Harry Brielmann , Stephane De Lombaert , Xiaozhang Zheng
发明人： Rajagopal Bakthavatchalam , Charles A. Blum , Harry Brielmann , Stephane De Lombaert , Xiaozhang Zheng
IPC分类号： A61K31/519 , C07D401/04 , C07D401/14 , C12N5/00 , A61P3/04 , A61P43/00 , A61P25/00 , C07D471/04 , A61K31/506
CPC分类号： C07D401/04 , C07D401/14 , C07D405/14
摘要： Substituted (7-pyridyl-4-phenylamino-quinazolin-2-yl)-methanol analogues are provided. Such compounds are ligands that may be used to modulate specific receptor activity in vivo or in vitro, and are particularly useful in the treatment of conditions associated with pathological receptor activation in humans, domesticated companion animals and livestock animals. Pharmaceutical compositions and methods for using them to treat such disorders are provided, as are methods for using such ligands for receptor localization studies.
摘要翻译： 提供了取代的（7-吡啶基-4-苯基氨基 - 喹唑啉-2-基） - 甲醇类似物。 这些化合物是可用于在体内或体外调节特异性受体活性的配体，并且特别可用于治疗与人类，驯养伴侣动物和家畜中的病理受体激活相关的病症。 还提供了用于治疗这些病症的药物组合物和方法，以及使用这些配体进行受体定位研究的方法。
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公开(公告)号：US07074799B2
公开(公告)日：2006-07-11
申请号：US10347210
申请日：2003-01-17
申请人： Rajagopal Bakthavatchalam , Charles A. Blum , Harry Brielmann , Timothy M. Caldwell , Stephane De Lombaert , Kevin J. Hodgetts , Xiaozhang Zheng
发明人： Rajagopal Bakthavatchalam , Charles A. Blum , Harry Brielmann , Timothy M. Caldwell , Stephane De Lombaert , Kevin J. Hodgetts , Xiaozhang Zheng
IPC分类号： C07D403/12 , C07D403/14 , A61K31/519 , A61P3/04
CPC分类号： C07D401/04 , C07D215/42 , C07D215/44 , C07D237/34 , C07D239/94 , C07D401/12 , C07D401/14 , C07D413/14 , C07D417/14 , C07D419/14 , C07D471/04
摘要： Substituted quinazolin-4-ylamine analogues are provided. Such compounds are ligands that may be used to modulate specific receptor activity in vivo or in vitro, and are particularly useful in the treatment of conditions associated with pathological receptor activation in humans, domesticated companion animals and livestock animals. Pharmaceutical compositions and methods for using them to treat such disorders are provided, as are methods for using such ligands for receptor localization studies.
摘要翻译： 提供了取代的喹唑啉-4-基胺类似物。 这些化合物是可用于在体内或体外调节特异性受体活性的配体，并且特别可用于治疗与人类，驯养伴侣动物和家畜中的病理受体激活相关的病症。 还提供了用于治疗这些病症的药物组合物和方法，以及使用这些配体进行受体定位研究的方法。
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