公开(公告)号：US5447692A

公开(公告)日：1995-09-05

申请号：US337311

申请日：1994-11-10

申请人： Charles A. Keenan ,  Peter J. Coassin ,  David B. Helphrey ,  Roger Winer ,  Jiunn-Jye Dih

发明人： Charles A. Keenan ,  Peter J. Coassin ,  David B. Helphrey ,  Roger Winer ,  Jiunn-Jye Dih

IPC分类号： C12M1/00 ,  B01J19/00 ,  C07H21/00 ,  C07K1/04 ,  C40B40/06 ,  C40B60/14 ,  G01F1/708 ,  G05B17/00 ,  G01F13/00 ,  G01N21/00

CPC分类号： C07H21/00 ,  B01J19/0046 ,  C07K1/045 ,  G01F1/708 ,  G01F1/7086 ,  B01J2219/00353 ,  B01J2219/00391 ,  B01J2219/00689 ,  B01J2219/00698 ,  B01J2219/00722 ,  C40B40/06 ,  C40B60/14 ,  Y10T436/11

摘要： The present invention makes use of a single detector to monitor several process functions, e.g. reaction efficiency, reagent flow rates, the presence of empty reagent reservoirs, the absence of a chemical reactor column in the system, blockage of flow system, etc., at a single location in the flow system. In accordance with the detection scheme of the present invention, only one detector is required to accomplish the same, if not more, functions as many detectors in the prior art instruments. In the described embodiment, an optical detector is positioned downstream of a chemical reaction chamber. This detector monitors the effluent from the reaction chamber to monitor the reaction efficiency. It also monitors the system functions upstream of the reaction chamber. System flow rate is monitored by detecting the presence of a gas bubble which has been introduced into the system at a known instance. Depletion of reagents in the reservoirs can be detected by monitoring the absence of the reagents at the detector at times when the reagents are expected. The flow system may be periodically diagnosed to check for flow blockage or missing flow component, by monitoring the flow past the detector which corresponds to a predetermined succession of reagents introduced into the system. Any deviation from a predictable succession of changes in the flow monitored by the detector indicates possible blockage of the flow delivery system or missing flow components.

摘要翻译： 本发明利用单个检测器来监视多个过程功能，例如， 反应效率，试剂流量，空试剂储存器的存在，系统中没有化学反应器塔，堵塞流动系统等，在流动系统的单个位置。 根据本发明的检测方案，仅需要一个检测器来实现与现有技术的仪器相同的（如果不是更多的）功能的检测器。 在所描述的实施例中，光学检测器位于化学反应室的下游。 该检测器监测来自反应室的流出物以监测反应效率。 它还监控反应室上游的系统功能。 通过检测在已知情况下已经引入到系统中的气泡的存在来监测系统流量。 可以通过在预期的时候监测检测器处的​​试剂的不存在来检测储存器中试剂的消耗。 可以通过监测通过检测器的流量来对应于引入到系统中的预定的一系列试剂，周期性地诊断流量系统来检查流体阻塞或缺少流动成分。 由检测器监测的流量的可预测连续变化的任何偏差表明流量输送系统或缺少流动分量的可能的阻塞。