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    Sample wash station assembly
    7.
    发明授权
    Sample wash station assembly 失效

    公开(公告)号：US5976470A

    公开(公告)日：1999-11-02

    申请号：US87376

    申请日：1998-05-29

    申请人： Romaine Maiefski ,  Don Wendell

    发明人： Romaine Maiefski ,  Don Wendell

    IPC分类号： G01N1/14 ,  B01J19/00 ,  C40B60/14 ,  G01N1/34 ,  G01N35/10

    CPC分类号： G01N35/1067 ,  B01J19/0046 ,  B01J2219/00313 ,  B01J2219/00351 ,  B01J2219/00373 ,  B01J2219/00376 ,  B01J2219/00389 ,  B01J2219/00391 ,  B01J2219/00416 ,  B01J2219/00418 ,  B01J2219/00484 ,  C40B60/14 ,  G01N35/1065 ,  Y10T436/11 ,  Y10T436/25 ,  Y10T436/2575

    摘要： A wash station assembly and method for washing selected samples in a sample containing assembly. The wash station assembly includes a wash station having a frame and a fluid dispensing assembly connected to the frame. The fluid dispensing assembly has a selector valve that is connectable to a plurality of fluid lines and is adjustable to allow only one of the fluids to pass through the selector valve at a time. An array of syringes is coupled to the selector valve and positioned to receive the fluid passing through the selector valve. Each syringe includes a check valve that prevents backflow of fluid or air into the syringe through the pipetting needles. A distribution manifold is connected to the selector valve and receives the fluid passing through the selector valve. The manifold has a plurality of distribution channels coupled to the syringes, to direct the fluid into the syringes. Each distribution channel has a manifold valve therein that prevents backflow of fluid into the manifold from the syringes. An array of pipetting needles is connected to the syringes and is positioned to direct the fluid into the sample containing assembly for washing the samples. The pipetting needles have a radially directed opening in the distal end to direct the fluid radially away from the needle during the dispensing process. A waste management system is connected to the wash station to automatically separate halogenated waste fluids from non-halogenated waste fluids.

    On-line process flow and reaction monitor
    8.
    发明授权
    On-line process flow and reaction monitor 失效
    在线工艺流程和反应监测

    公开(公告)号：US5447692A

    公开(公告)日：1995-09-05

    申请号：US337311

    申请日：1994-11-10

    申请人： Charles A. Keenan ,  Peter J. Coassin ,  David B. Helphrey ,  Roger Winer ,  Jiunn-Jye Dih

    发明人： Charles A. Keenan ,  Peter J. Coassin ,  David B. Helphrey ,  Roger Winer ,  Jiunn-Jye Dih

    IPC分类号： C12M1/00 ,  B01J19/00 ,  C07H21/00 ,  C07K1/04 ,  C40B40/06 ,  C40B60/14 ,  G01F1/708 ,  G05B17/00 ,  G01F13/00 ,  G01N21/00

    CPC分类号： C07H21/00 ,  B01J19/0046 ,  C07K1/045 ,  G01F1/708 ,  G01F1/7086 ,  B01J2219/00353 ,  B01J2219/00391 ,  B01J2219/00689 ,  B01J2219/00698 ,  B01J2219/00722 ,  C40B40/06 ,  C40B60/14 ,  Y10T436/11

    摘要： The present invention makes use of a single detector to monitor several process functions, e.g. reaction efficiency, reagent flow rates, the presence of empty reagent reservoirs, the absence of a chemical reactor column in the system, blockage of flow system, etc., at a single location in the flow system. In accordance with the detection scheme of the present invention, only one detector is required to accomplish the same, if not more, functions as many detectors in the prior art instruments. In the described embodiment, an optical detector is positioned downstream of a chemical reaction chamber. This detector monitors the effluent from the reaction chamber to monitor the reaction efficiency. It also monitors the system functions upstream of the reaction chamber. System flow rate is monitored by detecting the presence of a gas bubble which has been introduced into the system at a known instance. Depletion of reagents in the reservoirs can be detected by monitoring the absence of the reagents at the detector at times when the reagents are expected. The flow system may be periodically diagnosed to check for flow blockage or missing flow component, by monitoring the flow past the detector which corresponds to a predetermined succession of reagents introduced into the system. Any deviation from a predictable succession of changes in the flow monitored by the detector indicates possible blockage of the flow delivery system or missing flow components.

    摘要翻译： 本发明利用单个检测器来监视多个过程功能，例如， 反应效率，试剂流量，空试剂储存器的存在，系统中没有化学反应器塔，堵塞流动系统等，在流动系统的单个位置。 根据本发明的检测方案，仅需要一个检测器来实现与现有技术的仪器相同的（如果不是更多的）功能的检测器。 在所描述的实施例中，光学检测器位于化学反应室的下游。 该检测器监测来自反应室的流出物以监测反应效率。 它还监控反应室上游的系统功能。 通过检测在已知情况下已经引入到系统中的气泡的存在来监测系统流量。 可以通过在预期的时候监测检测器处的​​试剂的不存在来检测储存器中试剂的消耗。 可以通过监测通过检测器的流量来对应于引入到系统中的预定的一系列试剂，周期性地诊断流量系统来检查流体阻塞或缺少流动成分。 由检测器监测的流量的可预测连续变化的任何偏差表明流量输送系统或缺少流动分量的可能的阻塞。

    Fluid delivery system utilizing multiple port valve
    9.
    发明授权
    Fluid delivery system utilizing multiple port valve 失效
    流体输送系统采用多口阀

    公开(公告)号：US5405585A

    公开(公告)日：1995-04-11

    申请号：US277299

    申请日：1994-04-12

    申请人： Peter J. Coassin

    发明人： Peter J. Coassin

    IPC分类号： C07H21/04 ,  B01J4/00 ,  B01J19/00 ,  C07H21/00 ,  C07K1/04 ,  C40B40/06 ,  C40B60/14 ,  G01N1/00 ,  G01N1/31 ,  B01L3/02

    CPC分类号： G01N35/1097 ,  B01J19/0046 ,  C07H21/00 ,  C07K1/045 ,  B01J2219/00353 ,  B01J2219/00391 ,  B01J2219/0059 ,  B01J2219/00722 ,  C40B40/06 ,  C40B60/14 ,  G01N1/31 ,  Y10T137/86566

    摘要： The present invention is directed to the implementation of a multi-port rotary valve in an automated chemistry processing instrument which reduces chemical reagent cross contamination and simplifies system design and control. One or more multi-port rotary valves are used in conjunction with isolation valves which are each dedicated for an associated reagent in the system. According to one embodiment of the present invention, the instrument utilizes a multi-port valve which defines several fluid branches each associated with a reagent. The valve has a common inlet and common outlet which are selectively brought into fluid communication with the branches in a controlled sequence. At each branch, there is a two-way three-port isolation valve which controls introduction of an associated reagent into the branch. When a branch is selected by the rotary valve, the reagent introduced into the branch is delivered out of the common outlet by the flow from the common inlet. According to another embodiment of the present invention, the reagents are introduced through isolation valves between two multi-port rotary valves.

    摘要翻译： 本发明涉及一种减少化学试剂交叉污染并简化系统设计和控制的自动化学处​​理仪器中的多端口旋转阀的实现。 一个或多个多端口旋转阀与隔离阀一起使用，每个隔离阀专用于系统中的相关试剂。 根据本发明的一个实施例，仪器使用多端口阀，其限定了与试剂相关联的几个流体分支。 阀具有共同的入口和公共出口，其以受控的顺序选择性地与分支流体连通。 在每个分支处，存在一个双向三端口隔离阀，其控制将相关试剂引入分支中。 当通过旋转阀选择分支时，引入分支的试剂通过来自公共入口的流量从公共出口排出。 根据本发明的另一个实施方案，试剂通过两个多端口旋转阀之间的隔离阀引入。