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公开(公告)号：US08577621B2
公开(公告)日：2013-11-05
申请号：US13289822
申请日：2011-11-04
CPC分类号： G06F19/20 , B01J2219/00549 , B01J2219/00565 , B01J2219/00659 , B01J2219/00668 , B01J2219/00702 , B01J2219/00722 , B01J2219/00725 , C40B40/06 , C40B40/10 , C40B70/00
摘要： A method for processing biopolymer arrays and apparatus and computer program products for executing the method. The method may include reading a different array identifier for each biopolymer array from a tag associated with that array. At least some of the biopolymer arrays are read and results from each read array saved in a memory linked with the read identifier for that array. Different communication addresses and a selection of an array identifier for each, are received. For at least some of the arrays, the saved results for each are matched with one of the different communication addresses using the identifier, and the saved results transmitted for those arrays to the matched different communication addresses. A method of processing data from the reading of biopolymer arrays is also provided.
摘要翻译： 用于处理生物聚合物阵列的方法和用于执行该方法的装置和计算机程序产品。 该方法可以包括从与该阵列相关联的标签读取每个生物聚合物阵列的不同阵列标识符。 读取至少一些生物聚合物阵列，并将每个读取阵列的结果保存在与该阵列的读取标识符相链接的存储器中。 接收不同的通信地址和每个的阵列标识符的选择。 对于至少一些阵列，每个的保存结果与使用标识符的不同通信地址之一进行匹配，并将保存的结果发送给匹配的不同通信地址。 还提供了从读取生物聚合物阵列处理数据的方法。
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公开(公告)号：US20120053086A1
公开(公告)日：2012-03-01
申请号：US13289822
申请日：2011-11-04
CPC分类号： G06F19/20 , B01J2219/00549 , B01J2219/00565 , B01J2219/00659 , B01J2219/00668 , B01J2219/00702 , B01J2219/00722 , B01J2219/00725 , C40B40/06 , C40B40/10 , C40B70/00
摘要： A method for processing biopolymer arrays and apparatus and computer program products for executing the method. The method may include reading a different array identifier for each biopolymer array from a tag associated with that array. At least some of the biopolymer arrays are read and results from each read array saved in a memory linked with the read identifier for that array. Different communication addresses and a selection of an array identifier for each, are received. For at least some of the arrays, the saved results for each are matched with one of the different communication addresses using the identifier, and the saved results transmitted for those arrays to the matched different communication addresses. A method of processing data from the reading of biopolymer arrays is also provided.
摘要翻译： 用于处理生物聚合物阵列的方法和用于执行该方法的装置和计算机程序产品。 该方法可以包括从与该阵列相关联的标签读取每个生物聚合物阵列的不同阵列标识符。 读取至少一些生物聚合物阵列，并将每个读取阵列的结果保存在与该阵列的读取标识符相链接的存储器中。 接收不同的通信地址和每个的阵列标识符的选择。 对于至少一些阵列，每个的保存结果与使用标识符的不同通信地址之一进行匹配，并将保存的结果发送给匹配的不同通信地址。 还提供了从读取生物聚合物阵列处理数据的方法。
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公开(公告)号：US06993172B2
公开(公告)日：2006-01-31
申请号：US09895756
申请日：2001-06-29
申请人： Scott D. Connell , Herbert F. Cattell , Glenda C. Delenstarr , Nicholas M Sampas , Andreas N. Dorsel
发明人： Scott D. Connell , Herbert F. Cattell , Glenda C. Delenstarr , Nicholas M Sampas , Andreas N. Dorsel
IPC分类号： G06K9/00
CPC分类号： G01N21/253
摘要： A method and system for employing pixel-based, signal-intensity data contained within areas of a scanned image of a molecular array corresponding to features and feature backgrounds in order to determine whether or not the features or feature backgrounds have non-uniform signal intensities and are thus outlier features and outlier feature backgrounds. A calculated, estimated variance for the signal intensities within a feature or feature background is compared to a maximum allowable variance calculated for the feature or feature background based on a signal intensity variance model. When the experimental variance is less than or equal to the maximum allowable variance, the feature or feature background is considered to have acceptable signal-intensity uniformity. Otherwise, the feature or feature background is flagged as an outlier feature or outlier feature background.
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公开(公告)号：US08073626B2
公开(公告)日：2011-12-06
申请号：US10355571
申请日：2003-01-31
CPC分类号： G06F19/20 , B01J2219/00549 , B01J2219/00565 , B01J2219/00659 , B01J2219/00668 , B01J2219/00702 , B01J2219/00722 , B01J2219/00725 , C40B40/06 , C40B40/10 , C40B70/00
摘要： A method for processing biopolymer arrays and apparatus and computer program products for executing the method. The method may include reading a different array identifier for each biopolymer array from a tag associated with that array. At least some of the biopolymer arrays are read and results from each read array saved in a memory linked with the read identifier for that array. Different communication addresses and a selection of an array identifier for each, are received. For at least some of the arrays, the saved results for each are matched with one of the different communication addresses using the identifier, and the saved results transmitted for those arrays to the matched different communication addresses. A method of processing data from the reading of biopolymer arrays is also provided.
摘要翻译： 用于处理生物聚合物阵列的方法和用于执行该方法的装置和计算机程序产品。 该方法可以包括从与该阵列相关联的标签读取每个生物聚合物阵列的不同阵列标识符。 读取至少一些生物聚合物阵列，并将每个读取阵列的结果保存在与该阵列的读取标识符相链接的存储器中。 接收不同的通信地址和每个的阵列标识符的选择。 对于至少一些阵列，每个的保存结果与使用标识符的不同通信地址之一进行匹配，并将保存的结果发送到匹配的不同通信地址。 还提供了从读取生物聚合物阵列处理数据的方法。
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公开(公告)号：US07006927B2
公开(公告)日：2006-02-28
申请号：US10086839
申请日：2002-02-28
申请人： Zohar Yakhini , Cynthia Y. Enderwick , Glenda C. Delenstarr , Paul K. Wolber , Nicholas M. Sampas , Herbert F. Cattell , Scott D. Connell
发明人： Zohar Yakhini , Cynthia Y. Enderwick , Glenda C. Delenstarr , Paul K. Wolber , Nicholas M. Sampas , Herbert F. Cattell , Scott D. Connell
IPC分类号： G06F11/32
CPC分类号： G06T7/73 , G06T2207/30072
摘要： A method and system for extracting data signals from a scanned image resulting from optical, radiometric, or other types of analysis of a molecular array. The positions of corner features are first located. Then, an initial feature coordinate grid is determined from the positions of the corner features. A refined feature coordinate grid is then calculated based on the positions of strong features, and is used to identify the positions of weak features and the positions of the local background regions surrounding all features. Finally, signal intensity values are extracted from the features and their respective local background regions in the scanned image, and background-subtracted signal intensity values, background-subtracted and normalized signal intensity ratios, and variability information and confidence intervals are determined based on the extracted values.
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公开(公告)号：US07412085B2
公开(公告)日：2008-08-12
申请号：US11375658
申请日：2006-03-13
IPC分类号： G06K9/00
CPC分类号： G06K9/3216 , B01J2219/00378 , B01J2219/00608 , B01J2219/00612 , B01J2219/00659 , B01J2219/00693 , B01J2219/00704 , B01J2219/00722 , B01J2219/00725 , C12Q1/6837 , G06F19/20 , G06F19/24 , G06T7/73 , G06T2207/30072
摘要： Methods for correcting systematic errors in the measured position of deposited features of a nucleic acid array on a substrate. Systematic errors are modeled by an algorithmic model based on measuring the positions (and possibly other properties) of a subset of the features, and a model is constructed for predicting deviations in feature position from an ideal grid. Deviations arising in the deposition process, the scanning process, or both may be corrected.
摘要翻译： 用于校正基底上核酸阵列的沉积特征的测量位置的系统误差的方法。 系统误差是通过基于测量特征子集的位置（以及可能的其他属性）的算法模型来建模的，并且构建用于预测特征位置与理想网格的偏差的模型。 在沉积过程中产生的偏差，扫描过程或两者都可以被校正。
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7.发明授权Method and system for measuring a molecular array background signal from a continuous background region of specified size 失效用于测量来自指定尺寸的连续背景区域的分子阵列背景信号的方法和系统公开(公告)号：US07221785B2
公开(公告)日：2007-05-22
申请号：US10153394
申请日：2002-05-21
申请人： Bo U. Curry , Herbert F. Cattell , Srinka Ghosh
发明人： Bo U. Curry , Herbert F. Cattell , Srinka Ghosh
CPC分类号： G06K9/00 , G06T7/11 , G06T7/194 , G06T2207/10056 , G06T2207/10064 , G06T2207/30072
摘要： A method and system for estimating the background signal over an arbitrarily-sized region of a scanned image of a molecular array, including a background region surrounding the ROI corresponding to the feature. A bit mask is generated, based on a molecular-array, feature-based data set that includes pixel-based intensities and a list of features, including feature coordinates and feature ROI radii, to indicate those pixels in the scanned image of the molecular array corresponding to background, and those pixels in the scanned image of the molecular array corresponding to features and ROIs. An integrated intensity for a background region of arbitrary size and shape can be efficiently determined by selecting pixels within the background region that are indicated to be background pixels in the bit mask. By selecting background anuli of sufficient size to overlap with the background anuli of neighboring features, a relatively continuous function of background-signal-verusus-position can be obtained across the surface of a molecular array in order to examine non-local, background-signal-related phenomena.
摘要翻译： 一种用于在分子阵列的扫描图像的任意大小的区域上估计背景信号的方法和系统，包括与特征对应的ROI的背景区域。 基于分子阵列生成位掩模，基于特征的数据集，其包括基于像素的强度和包括特征坐标和特征ROI半径的特征列表，以指示分子阵列的扫描图像中的那些像素 对应于背景，并且分子阵列的扫描图像中的像素对应于特征和ROI。 可以通过选择背景区域中被指示为位掩码中的背景像素的像素来有效地确定用于任意尺寸和形状的背景区域的积分强度。 通过选择具有足够大小的背景与相邻特征的背景重叠的背景，可以跨分子阵列的表面获得背景信号 - 维基位置的相对连续的函数，以便检查非局部背景信号 相关现象。
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公开(公告)号：US07027930B2
公开(公告)日：2006-04-11
申请号：US09775163
申请日：2001-01-31
申请人： Herbert F. Cattell
发明人： Herbert F. Cattell
CPC分类号： G06F19/20
摘要： Methods of using an addressable array of biopolymers which has been exposed to a sample, and apparatus and computer program products for use of the arrays. In one embodiment the method includes detecting signals from the exposed array to obtain a signal image of the array. The array signal image is saved in a memory. Based on the detected signals, a shape of each region in one or more sets of multiple regions on the array signal image is established. A definition of the shapes of the established regions of each set is saved in a memory. Each region of each set is processed according to a corresponding routine for that set.
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公开(公告)号：US07027629B2
公开(公告)日：2006-04-11
申请号：US10238922
申请日：2002-09-09
IPC分类号： G06K9/00
CPC分类号： G06K9/3216 , B01J2219/00378 , B01J2219/00608 , B01J2219/00612 , B01J2219/00659 , B01J2219/00693 , B01J2219/00704 , B01J2219/00722 , B01J2219/00725 , C12Q1/6837 , G06F19/20 , G06F19/24 , G06T7/73 , G06T2207/30072
摘要： Methods for correcting systematic errors in the measured position of deposited features of a nucleic acid array on a substrate. Systematic errors are modeled by an algorithmic model based on measuring the positions (and possibly other properties) of a subset of the features, and a model is constructed for predicting deviations in feature position from an ideal grid. Deviations arising in the deposition process, the scanning process, or both may be corrected.
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公开(公告)号：US06913200B2
公开(公告)日：2005-07-05
申请号：US10301471
申请日：2002-11-20
CPC分类号： G01N21/6452 , G01N33/52 , G01N33/582 , G01N33/68 , G01N2201/0484
摘要： Methods for programming an array scanner to scan a plurality of biopolymer arrays are provided. In the subject methods, individual scanning parameters for at least two different arrays of the plurality of arrays to be scanned are selected and input into the array scanner prior to scanning the plurality arrays. The programmed scanner then scans the plurality of arrays according to the pre-selected scanning parametersAlso provided are scanners programmed according to the subject methods, as well as computer programming that provides for programming of scanners according to the subject methods. The subject methods and compositions find use in a variety of different applications, including both genomics and proteomics applications.
摘要翻译： 提供了对阵列扫描器进行编程以扫描多个生物聚合物阵列的方法。 在主题方法中，在扫描多个阵列之前，选择要扫描的多个阵列的至少两个不同阵列的各个扫描参数并将其输入阵列扫描器。 编程的扫描仪然后根据预先选择的扫描参数扫描多个阵列。还提供根据主题方法编程的扫描仪，以及根据主题方法提供对扫描仪的编程的计算机编程。 主题方法和组合物可用于各种不同的应用，包括基因组学和蛋白质组学应用。
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