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公开(公告)号：US07172757B2
公开(公告)日：2007-02-06
申请号：US10606055
申请日：2003-06-25
IPC分类号： A61K39/00 , A61K39/395
CPC分类号： A61K39/3955 , A61K38/1808 , A61K38/1825 , A61K38/1841 , A61K38/1866 , A61K38/1875 , C04B38/06 , C04B2111/00224 , C04B2111/00612 , C07K14/52 , C07K16/22 , C07K16/2863 , C07K2317/34 , C07K2319/00 , C12N2799/022 , C04B20/008 , C04B35/2641 , C04B35/50 , C04B35/64 , C04B38/0054 , C04B38/007 , C04B41/4578 , A61K2300/00
摘要： Materials and methods for reducing cell proliferation or extracellular matrix production in a mammal are disclosed. The methods comprise administering to a mammal a composition comprising a therapeutically effective amount of a zvegf4 antagonist in combination with a pharmaceutically acceptable delivery vehicle. Exemplary zvegf4 antagonists include anti-zvegf4 antibodies, inhibitory polynucleotides, inhibitors of zvegf4 activation, and mitogenically inactive, receptor-binding variants of zvegf4. The materials and methods are useful in the treatment of, inter alia, fibroproliferative disorders of the kidney, liver, and bone.
摘要翻译： 公开了用于减少哺乳动物细胞增殖或细胞外基质产生的材料和方法。 所述方法包括向哺乳动物施用包含治疗有效量的zvegf4拮抗剂与药学上可接受的递送载体的组合物。 示例性的zvegf4拮抗剂包括抗zvegf4抗体，抑制性多核苷酸，zvegf4激活的抑制剂和zvegf4的有丝分裂失活的受体结合变体。 所述材料和方法尤其用于治疗肾脏，肝脏和骨骼的纤维增生性疾病。
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公开(公告)号：US07722870B2
公开(公告)日：2010-05-25
申请号：US11539271
申请日：2006-10-06
IPC分类号： A61K39/395 , C12P21/08 , C07K16/18 , C07K14/435
CPC分类号： A61K39/3955 , A61K38/1808 , A61K38/1825 , A61K38/1841 , A61K38/1866 , A61K38/1875 , C04B38/06 , C04B2111/00224 , C04B2111/00612 , C07K14/52 , C07K16/22 , C07K16/2863 , C07K2317/34 , C07K2319/00 , C12N2799/022 , C04B20/008 , C04B35/2641 , C04B35/50 , C04B35/64 , C04B38/0054 , C04B38/007 , C04B41/4578 , A61K2300/00
摘要： Materials and methods for reducing cell proliferation or extracellular matrix production in a mammal are disclosed. The methods comprise administering to a mammal a composition comprising a therapeutically effective amount of a zvegf4 antagonist in combination with a pharmaceutically acceptable delivery vehicle. Exemplary zvegf4 antagonists include anti-zvegf4 antibodies, inhibitory polynucleotides, inhibitors of zvegf4 activation, and mitogenically inactive, receptor-binding variants of zvegf4. The materials and methods are useful in the treatment of, inter alia, fibroproliferative disorders of the kidney, liver, and bone.
摘要翻译： 公开了用于减少哺乳动物细胞增殖或细胞外基质产生的材料和方法。 所述方法包括向哺乳动物施用包含治疗有效量的zvegf4拮抗剂与药学上可接受的递送载体的组合物。 示例性的zvegf4拮抗剂包括抗zvegf4抗体，抑制性多核苷酸，zvegf4激活的抑制剂和zvegf4的有丝分裂失活的受体结合变体。 所述材料和方法尤其用于治疗肾脏，肝脏和骨骼的纤维增生性疾病。
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公开(公告)号：US08431129B2
公开(公告)日：2013-04-30
申请号：US13619228
申请日：2012-09-14
IPC分类号： A61K39/395 , C12P21/08 , C07K16/18 , C07K14/435
CPC分类号： A61K39/3955 , A61K38/1808 , A61K38/1825 , A61K38/1841 , A61K38/1866 , A61K38/1875 , C04B38/06 , C04B2111/00224 , C04B2111/00612 , C07K14/52 , C07K16/22 , C07K16/2863 , C07K2317/34 , C07K2319/00 , C12N2799/022 , C04B20/008 , C04B35/2641 , C04B35/50 , C04B35/64 , C04B38/0054 , C04B38/007 , C04B41/4578 , A61K2300/00
摘要： Materials and Methods for reducing cell proliferation or extracellular matrix production in a mammal are disclosed. The methods comprise administering to a mammal a composition comprising a therapeutically effective amount of a zvegf4 antagonist in combination with a pharmaceutically acceptable delivery vehicle. Exemplary zvegf4 antagonists include anti-zvegf4 antibodies, inhibitory polynucleotides, inhibitors of zvegf4 activation, and mitogenically inactive, receptor-binding variants of zvegf4. The materials and methods are useful in the treatment of, inter alia, fibroproliferative disorders of the kidney, liver, and bone.
摘要翻译： 公开了用于减少哺乳动物细胞增殖或细胞外基质产生的材料和方法。 所述方法包括向哺乳动物施用包含治疗有效量的zvegf4拮抗剂与药学上可接受的递送载体的组合物。 示例性的zvegf4拮抗剂包括抗zvegf4抗体，抑制性多核苷酸，zvegf4激活的抑制剂和zvegf4的有丝分裂失活的受体结合变体。 所述材料和方法尤其用于治疗肾脏，肝脏和骨骼的纤维增生性疾病。
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公开(公告)号：US08298534B2
公开(公告)日：2012-10-30
申请号：US12780809
申请日：2010-05-14
IPC分类号： A61K39/395 , C12P21/08 , C07K16/18 , C07K14/435
CPC分类号： A61K39/3955 , A61K38/1808 , A61K38/1825 , A61K38/1841 , A61K38/1866 , A61K38/1875 , C04B38/06 , C04B2111/00224 , C04B2111/00612 , C07K14/52 , C07K16/22 , C07K16/2863 , C07K2317/34 , C07K2319/00 , C12N2799/022 , C04B20/008 , C04B35/2641 , C04B35/50 , C04B35/64 , C04B38/0054 , C04B38/007 , C04B41/4578 , A61K2300/00
摘要： Materials and Methods for reducing cell proliferation or extracellular matrix production in a mammal are disclosed. The methods comprise administering to a mammal a composition comprising a therapeutically effective amount of a zvegf4 antagonist in combination with a pharmaceutically acceptable delivery vehicle. Exemplary zvegf4 antagonists include anti-zvegf4 antibodies, inhibitory polynucleotides, inhibitors of zvegf4 activation, and mitogenically inactive, receptor-binding variants of zvegf4. The materials and methods are useful in the treatment of, inter alia, fibroproliferative disorders of the kidney, liver, and bone.
摘要翻译： 公开了用于减少哺乳动物细胞增殖或细胞外基质产生的材料和方法。 所述方法包括向哺乳动物施用包含治疗有效量的zvegf4拮抗剂与药学上可接受的递送载体的组合物。 示例性的zvegf4拮抗剂包括抗zvegf4抗体，抑制性多核苷酸，zvegf4激活的抑制剂和zvegf4的有丝分裂失活的受体结合变体。 所述材料和方法尤其用于治疗肾脏，肝脏和骨骼的纤维增生性疾病。
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公开(公告)号：US20100291087A1
公开(公告)日：2010-11-18
申请号：US12780809
申请日：2010-05-14
IPC分类号： A61K39/395 , A61P35/00
CPC分类号： A61K39/3955 , A61K38/1808 , A61K38/1825 , A61K38/1841 , A61K38/1866 , A61K38/1875 , C04B38/06 , C04B2111/00224 , C04B2111/00612 , C07K14/52 , C07K16/22 , C07K16/2863 , C07K2317/34 , C07K2319/00 , C12N2799/022 , C04B20/008 , C04B35/2641 , C04B35/50 , C04B35/64 , C04B38/0054 , C04B38/007 , C04B41/4578 , A61K2300/00
摘要： Materials and Methods for reducing cell proliferation or extracellular matrix production in a mammal are disclosed. The methods comprise administering to a mammal a composition comprising a therapeutically effective amount of a zvegf4 antagonist in combination with a pharmaceutically acceptable delivery vehicle. Exemplary zvegf4 antagonists include anti-zvegf4 antibodies, inhibitory polynucleotides, inhibitors of zvegf4 activation, and mitogenically inactive, receptor-binding variants of zvegf4. The materials and methods are useful in the treatment of, inter alia, fibroproliferative disorders of the kidney, liver, and bone.
摘要翻译： 公开了用于减少哺乳动物细胞增殖或细胞外基质产生的材料和方法。 所述方法包括向哺乳动物施用包含治疗有效量的zvegf4拮抗剂与药学上可接受的递送载体的组合物。 示例性的zvegf4拮抗剂包括抗zvegf4抗体，抑制性多核苷酸，zvegf4激活的抑制剂和zvegf4的有丝分裂失活的受体结合变体。 所述材料和方法尤其用于治疗肾脏，肝脏和骨骼的纤维增生性疾病。
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公开(公告)号：US06630142B2
公开(公告)日：2003-10-07
申请号：US09808972
申请日：2001-03-14
IPC分类号： A61K39395
CPC分类号： A61K39/3955 , A61K38/1808 , A61K38/1825 , A61K38/1841 , A61K38/1866 , A61K38/1875 , C04B38/06 , C04B2111/00224 , C04B2111/00612 , C07K14/52 , C07K16/22 , C07K16/2863 , C07K2317/34 , C07K2319/00 , C12N2799/022 , C04B20/008 , C04B35/2641 , C04B35/50 , C04B35/64 , C04B38/0054 , C04B38/007 , C04B41/4578 , A61K2300/00
摘要： Materials and methods for reducing cell proliferation or extracellular matrix production in a mammal are disclosed. The methods comprise administering to a mammal a composition comprising a therapeutically effective amount of a zvegf4 antagonist in combination with a pharmaceutically acceptable delivery vehicle. Exemplary zvegf4 antagonists include anti-zvegf4 antibodies, inhibitory polynucleotides, inhibitors of zvegf4 activation, and mitogenically inactive, receptor-binding variants of zvegf4. The materials and methods are useful in the treatment of, inter alia, fibroproliferative disorders of the kidney, liver, and bone.
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公开(公告)号：US06432673B1
公开(公告)日：2002-08-13
申请号：US09457066
申请日：1999-12-07
申请人： Zeren Gao , Charles E. Hart , Christopher S. Piddington , Paul O. Sheppard , Kimberly E. Shoemaker , Debra G. Gilbertson , James W. West
发明人： Zeren Gao , Charles E. Hart , Christopher S. Piddington , Paul O. Sheppard , Kimberly E. Shoemaker , Debra G. Gilbertson , James W. West
IPC分类号： C12N1500
CPC分类号： C07K14/52 , A01K2217/05 , A61K38/1858 , C07K14/475 , C12N2799/022
摘要： Polypeptide growth factors, methods of making them, polynucleotides encoding them, antibodies to them, and methods of using them are disclosed. The polypeptides comprise an amino acid segment that is at least 90% identical to residues 46-163 of SEQ ID NO:2 or residues 235-345 of SEQ ID NO:2. Multimers of the polypeptides are also disclosed. The polypeptides, multimeric proteins, and polynucleotides can be used in the study and regulation of cell and tissue development, as components of cell culture media, and as diagnostic agents.
摘要翻译： 公开了多肽生长因子，其制备方法，编码它们的多核苷酸，针对它们的抗体及其使用方法。 多肽包含与SEQ ID NO：2的残基46-163或SEQ ID NO：2的残基235-345至少90％相同的氨基酸区段。 还公开了多肽的多聚体。 多肽，多聚体蛋白和多核苷酸可用于细胞和组织发育的研究和调节，作为细胞培养基的组分和诊断剂。
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公开(公告)号：US20090227022A1
公开(公告)日：2009-09-10
申请号：US12363540
申请日：2009-01-30
IPC分类号： C12N5/02
CPC分类号： C04B38/06 , A61K38/177 , A61K38/18 , A61K38/1866 , A61K38/22 , C04B2111/00224 , C04B2111/00612 , C07K14/52 , C07K2319/00 , C12N2799/022 , C04B20/008 , C04B35/2641 , C04B35/50 , C04B35/64 , C04B38/0054 , C04B38/007 , C04B41/4578 , A61K2300/00
摘要： Polypeptide growth factors, methods of making them, polynucleotides encoding them, antibodies to them, and methods of using them are disclosed. The polypeptides comprise an amino acid segment that is at least 70% identical to residues 52-179 of SEQ ID NO:2 or residues 258-370 of SEQ ID NO:2. Multimers of the polypeptides are also disclosed. The polypeptides, multimeric proteins, and polynucleotides can be used in the study and regulation of cell and tissue development, as components of cell culture media, and as diagnostic agents.
摘要翻译： 公开了多肽生长因子，其制备方法，编码它们的多核苷酸，针对它们的抗体以及使用它们的方法。 多肽包含与SEQ ID NO：2的残基52-179或SEQ ID NO：2的残基258-370至少70％相同的氨基酸区段。 还公开了多肽的多聚体。 多肽，多聚体蛋白和多核苷酸可用于细胞和组织发育的研究和调节，作为细胞培养基的组分和诊断剂。
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公开(公告)号：US06495668B1
公开(公告)日：2002-12-17
申请号：US09564595
申请日：2000-05-03
IPC分类号： A61K3824
CPC分类号： C04B38/06 , A61K38/177 , A61K38/18 , A61K38/1866 , A61K38/22 , C04B2111/00224 , C04B2111/00612 , C07K14/52 , C07K2319/00 , C12N2799/022 , C04B20/008 , C04B35/2641 , C04B35/50 , C04B35/64 , C04B38/0054 , C04B38/007 , C04B41/4578 , A61K2300/00
摘要： Polypeptide growth factors, methods of making them, polynucleotides encoding them, antibodies to them, and methods of using them are disclosed. Multimers of the polypeptides are also disclosed. The polypeptides, multimeric proteins, and polynucleotides can be used in the study and regulation of cell and tissue development, as components of cell culture media, and as diagnostic agents.
摘要翻译： 公开了多肽生长因子，其制备方法，编码它们的多核苷酸，针对它们的抗体以及使用它们的方法。 还公开了多肽的多聚体。 多肽，多聚体蛋白和多核苷酸可用于细胞和组织发育的研究和调节，作为细胞培养基的组分和诊断剂。
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公开(公告)号：US20120021518A1
公开(公告)日：2012-01-26
申请号：US13107758
申请日：2011-05-13
IPC分类号： C12N5/077
CPC分类号： C04B38/06 , A61K38/177 , A61K38/18 , A61K38/1866 , A61K38/22 , C04B2111/00224 , C04B2111/00612 , C07K14/52 , C07K2319/00 , C12N2799/022 , C04B20/008 , C04B35/2641 , C04B35/50 , C04B35/64 , C04B38/0054 , C04B38/007 , C04B41/4578 , A61K2300/00
摘要： Polypeptide growth factors, methods of making them, polynucleotides encoding them, antibodies to them, and methods of using them are disclosed. The polypeptides comprise an amino acid segment that is at least 70% identical to residues 52-179 of SEQ ID NO:2 or residues 258-370 of SEQ ID NO:2. Multimers of the polypeptides are also disclosed. The polypeptides, multimeric proteins, and polynucleotides can be used in the study and regulation of cell and tissue development, as components of cell culture media, and as diagnostic agents.
摘要翻译： 公开了多肽生长因子，其制备方法，编码它们的多核苷酸，针对它们的抗体以及使用它们的方法。 多肽包含与SEQ ID NO：2的残基52-179或SEQ ID NO：2的残基258-370至少70％相同的氨基酸区段。 还公开了多肽的多聚体。 多肽，多聚体蛋白和多核苷酸可用于细胞和组织发育的研究和调节，作为细胞培养基的组分和诊断剂。
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