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公开(公告)号：US07172757B2
公开(公告)日：2007-02-06
申请号：US10606055
申请日：2003-06-25
IPC分类号： A61K39/00 , A61K39/395
CPC分类号： A61K39/3955 , A61K38/1808 , A61K38/1825 , A61K38/1841 , A61K38/1866 , A61K38/1875 , C04B38/06 , C04B2111/00224 , C04B2111/00612 , C07K14/52 , C07K16/22 , C07K16/2863 , C07K2317/34 , C07K2319/00 , C12N2799/022 , C04B20/008 , C04B35/2641 , C04B35/50 , C04B35/64 , C04B38/0054 , C04B38/007 , C04B41/4578 , A61K2300/00
摘要： Materials and methods for reducing cell proliferation or extracellular matrix production in a mammal are disclosed. The methods comprise administering to a mammal a composition comprising a therapeutically effective amount of a zvegf4 antagonist in combination with a pharmaceutically acceptable delivery vehicle. Exemplary zvegf4 antagonists include anti-zvegf4 antibodies, inhibitory polynucleotides, inhibitors of zvegf4 activation, and mitogenically inactive, receptor-binding variants of zvegf4. The materials and methods are useful in the treatment of, inter alia, fibroproliferative disorders of the kidney, liver, and bone.
摘要翻译： 公开了用于减少哺乳动物细胞增殖或细胞外基质产生的材料和方法。 所述方法包括向哺乳动物施用包含治疗有效量的zvegf4拮抗剂与药学上可接受的递送载体的组合物。 示例性的zvegf4拮抗剂包括抗zvegf4抗体，抑制性多核苷酸，zvegf4激活的抑制剂和zvegf4的有丝分裂失活的受体结合变体。 所述材料和方法尤其用于治疗肾脏，肝脏和骨骼的纤维增生性疾病。
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公开(公告)号：US20100291087A1
公开(公告)日：2010-11-18
申请号：US12780809
申请日：2010-05-14
IPC分类号： A61K39/395 , A61P35/00
CPC分类号： A61K39/3955 , A61K38/1808 , A61K38/1825 , A61K38/1841 , A61K38/1866 , A61K38/1875 , C04B38/06 , C04B2111/00224 , C04B2111/00612 , C07K14/52 , C07K16/22 , C07K16/2863 , C07K2317/34 , C07K2319/00 , C12N2799/022 , C04B20/008 , C04B35/2641 , C04B35/50 , C04B35/64 , C04B38/0054 , C04B38/007 , C04B41/4578 , A61K2300/00
摘要： Materials and Methods for reducing cell proliferation or extracellular matrix production in a mammal are disclosed. The methods comprise administering to a mammal a composition comprising a therapeutically effective amount of a zvegf4 antagonist in combination with a pharmaceutically acceptable delivery vehicle. Exemplary zvegf4 antagonists include anti-zvegf4 antibodies, inhibitory polynucleotides, inhibitors of zvegf4 activation, and mitogenically inactive, receptor-binding variants of zvegf4. The materials and methods are useful in the treatment of, inter alia, fibroproliferative disorders of the kidney, liver, and bone.
摘要翻译： 公开了用于减少哺乳动物细胞增殖或细胞外基质产生的材料和方法。 所述方法包括向哺乳动物施用包含治疗有效量的zvegf4拮抗剂与药学上可接受的递送载体的组合物。 示例性的zvegf4拮抗剂包括抗zvegf4抗体，抑制性多核苷酸，zvegf4激活的抑制剂和zvegf4的有丝分裂失活的受体结合变体。 所述材料和方法尤其用于治疗肾脏，肝脏和骨骼的纤维增生性疾病。
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公开(公告)号：US07722870B2
公开(公告)日：2010-05-25
申请号：US11539271
申请日：2006-10-06
IPC分类号： A61K39/395 , C12P21/08 , C07K16/18 , C07K14/435
CPC分类号： A61K39/3955 , A61K38/1808 , A61K38/1825 , A61K38/1841 , A61K38/1866 , A61K38/1875 , C04B38/06 , C04B2111/00224 , C04B2111/00612 , C07K14/52 , C07K16/22 , C07K16/2863 , C07K2317/34 , C07K2319/00 , C12N2799/022 , C04B20/008 , C04B35/2641 , C04B35/50 , C04B35/64 , C04B38/0054 , C04B38/007 , C04B41/4578 , A61K2300/00
摘要： Materials and methods for reducing cell proliferation or extracellular matrix production in a mammal are disclosed. The methods comprise administering to a mammal a composition comprising a therapeutically effective amount of a zvegf4 antagonist in combination with a pharmaceutically acceptable delivery vehicle. Exemplary zvegf4 antagonists include anti-zvegf4 antibodies, inhibitory polynucleotides, inhibitors of zvegf4 activation, and mitogenically inactive, receptor-binding variants of zvegf4. The materials and methods are useful in the treatment of, inter alia, fibroproliferative disorders of the kidney, liver, and bone.
摘要翻译： 公开了用于减少哺乳动物细胞增殖或细胞外基质产生的材料和方法。 所述方法包括向哺乳动物施用包含治疗有效量的zvegf4拮抗剂与药学上可接受的递送载体的组合物。 示例性的zvegf4拮抗剂包括抗zvegf4抗体，抑制性多核苷酸，zvegf4激活的抑制剂和zvegf4的有丝分裂失活的受体结合变体。 所述材料和方法尤其用于治疗肾脏，肝脏和骨骼的纤维增生性疾病。
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公开(公告)号：US08431129B2
公开(公告)日：2013-04-30
申请号：US13619228
申请日：2012-09-14
IPC分类号： A61K39/395 , C12P21/08 , C07K16/18 , C07K14/435
CPC分类号： A61K39/3955 , A61K38/1808 , A61K38/1825 , A61K38/1841 , A61K38/1866 , A61K38/1875 , C04B38/06 , C04B2111/00224 , C04B2111/00612 , C07K14/52 , C07K16/22 , C07K16/2863 , C07K2317/34 , C07K2319/00 , C12N2799/022 , C04B20/008 , C04B35/2641 , C04B35/50 , C04B35/64 , C04B38/0054 , C04B38/007 , C04B41/4578 , A61K2300/00
摘要： Materials and Methods for reducing cell proliferation or extracellular matrix production in a mammal are disclosed. The methods comprise administering to a mammal a composition comprising a therapeutically effective amount of a zvegf4 antagonist in combination with a pharmaceutically acceptable delivery vehicle. Exemplary zvegf4 antagonists include anti-zvegf4 antibodies, inhibitory polynucleotides, inhibitors of zvegf4 activation, and mitogenically inactive, receptor-binding variants of zvegf4. The materials and methods are useful in the treatment of, inter alia, fibroproliferative disorders of the kidney, liver, and bone.
摘要翻译： 公开了用于减少哺乳动物细胞增殖或细胞外基质产生的材料和方法。 所述方法包括向哺乳动物施用包含治疗有效量的zvegf4拮抗剂与药学上可接受的递送载体的组合物。 示例性的zvegf4拮抗剂包括抗zvegf4抗体，抑制性多核苷酸，zvegf4激活的抑制剂和zvegf4的有丝分裂失活的受体结合变体。 所述材料和方法尤其用于治疗肾脏，肝脏和骨骼的纤维增生性疾病。
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公开(公告)号：US08298534B2
公开(公告)日：2012-10-30
申请号：US12780809
申请日：2010-05-14
IPC分类号： A61K39/395 , C12P21/08 , C07K16/18 , C07K14/435
CPC分类号： A61K39/3955 , A61K38/1808 , A61K38/1825 , A61K38/1841 , A61K38/1866 , A61K38/1875 , C04B38/06 , C04B2111/00224 , C04B2111/00612 , C07K14/52 , C07K16/22 , C07K16/2863 , C07K2317/34 , C07K2319/00 , C12N2799/022 , C04B20/008 , C04B35/2641 , C04B35/50 , C04B35/64 , C04B38/0054 , C04B38/007 , C04B41/4578 , A61K2300/00
摘要： Materials and Methods for reducing cell proliferation or extracellular matrix production in a mammal are disclosed. The methods comprise administering to a mammal a composition comprising a therapeutically effective amount of a zvegf4 antagonist in combination with a pharmaceutically acceptable delivery vehicle. Exemplary zvegf4 antagonists include anti-zvegf4 antibodies, inhibitory polynucleotides, inhibitors of zvegf4 activation, and mitogenically inactive, receptor-binding variants of zvegf4. The materials and methods are useful in the treatment of, inter alia, fibroproliferative disorders of the kidney, liver, and bone.
摘要翻译： 公开了用于减少哺乳动物细胞增殖或细胞外基质产生的材料和方法。 所述方法包括向哺乳动物施用包含治疗有效量的zvegf4拮抗剂与药学上可接受的递送载体的组合物。 示例性的zvegf4拮抗剂包括抗zvegf4抗体，抑制性多核苷酸，zvegf4激活的抑制剂和zvegf4的有丝分裂失活的受体结合变体。 所述材料和方法尤其用于治疗肾脏，肝脏和骨骼的纤维增生性疾病。
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公开(公告)号：US06630142B2
公开(公告)日：2003-10-07
申请号：US09808972
申请日：2001-03-14
IPC分类号： A61K39395
CPC分类号： A61K39/3955 , A61K38/1808 , A61K38/1825 , A61K38/1841 , A61K38/1866 , A61K38/1875 , C04B38/06 , C04B2111/00224 , C04B2111/00612 , C07K14/52 , C07K16/22 , C07K16/2863 , C07K2317/34 , C07K2319/00 , C12N2799/022 , C04B20/008 , C04B35/2641 , C04B35/50 , C04B35/64 , C04B38/0054 , C04B38/007 , C04B41/4578 , A61K2300/00
摘要： Materials and methods for reducing cell proliferation or extracellular matrix production in a mammal are disclosed. The methods comprise administering to a mammal a composition comprising a therapeutically effective amount of a zvegf4 antagonist in combination with a pharmaceutically acceptable delivery vehicle. Exemplary zvegf4 antagonists include anti-zvegf4 antibodies, inhibitory polynucleotides, inhibitors of zvegf4 activation, and mitogenically inactive, receptor-binding variants of zvegf4. The materials and methods are useful in the treatment of, inter alia, fibroproliferative disorders of the kidney, liver, and bone.
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公开(公告)号：US06432673B1
公开(公告)日：2002-08-13
申请号：US09457066
申请日：1999-12-07
申请人： Zeren Gao , Charles E. Hart , Christopher S. Piddington , Paul O. Sheppard , Kimberly E. Shoemaker , Debra G. Gilbertson , James W. West
发明人： Zeren Gao , Charles E. Hart , Christopher S. Piddington , Paul O. Sheppard , Kimberly E. Shoemaker , Debra G. Gilbertson , James W. West
IPC分类号： C12N1500
CPC分类号： C07K14/52 , A01K2217/05 , A61K38/1858 , C07K14/475 , C12N2799/022
摘要： Polypeptide growth factors, methods of making them, polynucleotides encoding them, antibodies to them, and methods of using them are disclosed. The polypeptides comprise an amino acid segment that is at least 90% identical to residues 46-163 of SEQ ID NO:2 or residues 235-345 of SEQ ID NO:2. Multimers of the polypeptides are also disclosed. The polypeptides, multimeric proteins, and polynucleotides can be used in the study and regulation of cell and tissue development, as components of cell culture media, and as diagnostic agents.
摘要翻译： 公开了多肽生长因子，其制备方法，编码它们的多核苷酸，针对它们的抗体及其使用方法。 多肽包含与SEQ ID NO：2的残基46-163或SEQ ID NO：2的残基235-345至少90％相同的氨基酸区段。 还公开了多肽的多聚体。 多肽，多聚体蛋白和多核苷酸可用于细胞和组织发育的研究和调节，作为细胞培养基的组分和诊断剂。
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公开(公告)号：US06827938B2
公开(公告)日：2004-12-07
申请号：US10039847
申请日：2001-10-26
申请人： Charles E. Hart , Stavros Topouzis
发明人： Charles E. Hart , Stavros Topouzis
IPC分类号： A61K3900
CPC分类号： A61K38/1875 , A61K38/1858
摘要： Materials and methods for improving kidney function or enhancing proliferation or survival of kidney tubule epithelial cells or epithelial cell precursors in a mammal are disclosed. The methods comprise administering to the mammal a composition comprising a therapeutically effective amount of a zvegf4 protein or a zvegf4 protein-encoding polynucleotide in combination with a pharmaceutically acceptable delivery vehicle. Zvegf4 proteins include, for example, disulfide-bonded dimers of two polypeptide chains, each comprising residues 258-370 of SEQ ID NO:2.
摘要翻译： 公开了用于改善哺乳动物中肾小管上皮细胞或上皮细胞前体的肾功能或增强增殖或存活的材料和方法。 所述方法包括向哺乳动物施用包含治疗有效量的zvegf4蛋白或编码zvegf4蛋白的多核苷酸与药学上可接受的递送载体组合的组合物。 Zvegf4蛋白包括例如两个多肽链的二硫键连接的二聚体，每个包含SEQ ID NO：2的残基258-370。
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公开(公告)号：US07951380B2
公开(公告)日：2011-05-31
申请号：US12363540
申请日：2009-01-30
IPC分类号： A61K39/00 , A61K38/00 , A61K38/18 , A61P35/00 , C07K14/00 , C07K1/00 , C12P21/06 , C12N15/00 , C12N5/00
CPC分类号： C04B38/06 , A61K38/177 , A61K38/18 , A61K38/1866 , A61K38/22 , C04B2111/00224 , C04B2111/00612 , C07K14/52 , C07K2319/00 , C12N2799/022 , C04B20/008 , C04B35/2641 , C04B35/50 , C04B35/64 , C04B38/0054 , C04B38/007 , C04B41/4578 , A61K2300/00
摘要： Polypeptide growth factors, methods of making them, polynucleotides encoding them, antibodies to them, and methods of using them are disclosed. The polypeptides comprise an amino acid segment that is at least 70% identical to residues 52-179 of SEQ ID NO:2 or residues 258-370 of SEQ ID NO:2. Multimers of the polypeptides are also disclosed. The polypeptides, multimeric proteins, and polynucleotides can be used in the study and regulation of cell and tissue development, as components of cell culture media, and as diagnostic agents.
摘要翻译： 公开了多肽生长因子，其制备方法，编码它们的多核苷酸，针对它们的抗体以及使用它们的方法。 多肽包含与SEQ ID NO：2的残基52-179或SEQ ID NO：2的残基258-370至少70％相同的氨基酸区段。 还公开了多肽的多聚体。 多肽，多聚体蛋白和多核苷酸可用于细胞和组织发育的研究和调节，作为细胞培养基的组分和诊断剂。
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公开(公告)号：US07491384B2
公开(公告)日：2009-02-17
申请号：US10664432
申请日：2003-09-19
CPC分类号： C07K14/52 , A01K2217/05 , A61K9/2027 , A61K38/1858 , A61K47/10 , A61K47/14 , A61K47/26 , A61K47/44 , A61L24/108 , A61L27/02 , A61L27/14 , A61L27/227 , A61L27/52 , A61L27/54 , A61L2300/252 , A61L2300/414 , A61L2300/43 , A61L2430/02 , A61L2430/10 , A61L2430/12 , C07K14/475 , C12N2799/022 , G01N2001/2223 , A61K2300/00
摘要： Methods for promoting growth of bone, ligament, or cartilage in a mammal are disclosed. The methods comprise administering to said mammal a composition comprising a pharmacologically effective amount of a zvegf3 protein in combination with a pharmaceutically acceptable delivery vehicle. Also disclosed are methods for promoting proliferation or differentiation of osteoblasts, osteoclasts, chondrocytes, or bone marrow stem cells comprising culturing the cells in an effective amount of a zvegf3 protein.
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