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公开(公告)号：US06432673B1
公开(公告)日：2002-08-13
申请号：US09457066
申请日：1999-12-07
申请人： Zeren Gao , Charles E. Hart , Christopher S. Piddington , Paul O. Sheppard , Kimberly E. Shoemaker , Debra G. Gilbertson , James W. West
发明人： Zeren Gao , Charles E. Hart , Christopher S. Piddington , Paul O. Sheppard , Kimberly E. Shoemaker , Debra G. Gilbertson , James W. West
IPC分类号： C12N1500
CPC分类号： C07K14/52 , A01K2217/05 , A61K38/1858 , C07K14/475 , C12N2799/022
摘要： Polypeptide growth factors, methods of making them, polynucleotides encoding them, antibodies to them, and methods of using them are disclosed. The polypeptides comprise an amino acid segment that is at least 90% identical to residues 46-163 of SEQ ID NO:2 or residues 235-345 of SEQ ID NO:2. Multimers of the polypeptides are also disclosed. The polypeptides, multimeric proteins, and polynucleotides can be used in the study and regulation of cell and tissue development, as components of cell culture media, and as diagnostic agents.
摘要翻译： 公开了多肽生长因子，其制备方法，编码它们的多核苷酸，针对它们的抗体及其使用方法。 多肽包含与SEQ ID NO：2的残基46-163或SEQ ID NO：2的残基235-345至少90％相同的氨基酸区段。 还公开了多肽的多聚体。 多肽，多聚体蛋白和多核苷酸可用于细胞和组织发育的研究和调节，作为细胞培养基的组分和诊断剂。
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公开(公告)号：US06814965B2
公开(公告)日：2004-11-09
申请号：US10139583
申请日：2002-05-02
申请人： Zeren Gao , Charles E. Hart , Christopher S. Piddington , Paul O. Sheppard , Kimberly E. Shoemaker , Debra G. Gilbertson , James W. West
发明人： Zeren Gao , Charles E. Hart , Christopher S. Piddington , Paul O. Sheppard , Kimberly E. Shoemaker , Debra G. Gilbertson , James W. West
IPC分类号： A61K39395
CPC分类号： C07K14/52 , A01K2217/05 , A61K38/1858 , C07K14/475 , C12N2799/022
摘要： Polypeptide growth factors, methods of making them, polynucleotides encoding them, antibodies to them, and methods of using them are disclosed. The polypeptides comprise an amino acid segment that is at least 90% identical to residues 46-163 of SEQ ID NO: 2 or residues 235-345 of SEQ ID NO: 2. Multimers of the polypeptides are also disclosed. The polypeptides, multimeric proteins, and polynucleotides can be used in the study and regulation of cell and tissue development, as components of cell culture media, and as diagnostic agents.
摘要翻译： 公开了多肽生长因子，其制备方法，编码它们的多核苷酸，针对它们的抗体以及使用它们的方法。 多肽包含与SEQ ID NO：2的残基46-163或SEQ ID NO：2的残基235-345至少90％相同的氨基酸区段。多肽的多聚体也被公开。 多肽，多聚体蛋白和多核苷酸可用于细胞和组织发育的研究和调节，作为细胞培养基的组分和诊断剂。
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公开(公告)号：US06528050B1
公开(公告)日：2003-03-04
申请号：US09706968
申请日：2000-11-06
申请人： Zeren Gao , Charles E. Hart , Christopher S. Piddington , Paul O. Sheppard , Kimberly E. Shoemaker , Debra G. Gilbertson , James W. West
发明人： Zeren Gao , Charles E. Hart , Christopher S. Piddington , Paul O. Sheppard , Kimberly E. Shoemaker , Debra G. Gilbertson , James W. West
IPC分类号： A61K4500
CPC分类号： C07K14/52 , A01K2217/05 , A61K38/1858 , C07K14/475 , C12N2799/022
摘要： Polypeptide growth factors, methods of making them, polynucleotides encoding them, antibodies to them, and methods of using them are disclosed. The polypeptides comprise an amino acid segment that is at least 90% identical to residues 46-163 of SEQ ID NO:2 or residues 235-345 of SEQ ID NO:2. Multimers of the polypeptides are also disclosed. The polypeptides, multimeric proteins, and polynucleotides can be used in the study and regulation of cell and tissue development, as components of cell culture media, and as diagnostic agents.
摘要翻译： 公开了多肽生长因子，其制备方法，编码它们的多核苷酸，针对它们的抗体以及使用它们的方法。 多肽包含与SEQ ID NO：2的残基46-163或SEQ ID NO：2的残基235-345至少90％相同的氨基酸区段。 还公开了多肽的多聚体。 多肽，多聚体蛋白和多核苷酸可用于细胞和组织发育的研究和调节，作为细胞培养基的组分和诊断剂。
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公开(公告)号：US07387885B2
公开(公告)日：2008-06-17
申请号：US11021088
申请日：2004-12-22
申请人： Zeren Gao , Charles E. Hart , Christopher S. Piddington , Paul O. Sheppard , Kimberly E. Shoemaker , Debra G. Gilbertson , James W. West
发明人： Zeren Gao , Charles E. Hart , Christopher S. Piddington , Paul O. Sheppard , Kimberly E. Shoemaker , Debra G. Gilbertson , James W. West
IPC分类号： C12N15/12
CPC分类号： C07K14/52 , A01K2217/05 , A61K38/1858 , C07K14/475 , C12N2799/022
摘要： Polypeptide growth factors, methods of making them, polynucleotides encoding them, antibodies to them, and methods of using them are disclosed. The polypeptides comprise an amino acid segment that is at least 90% identical to residues 46-163 of SEQ ID NO:2 or residues 235-345 of SEQ ID NO:2. Multimers of the polypeptides are also disclosed. The polypeptides, multimeric proteins, and polynucleotides can be used in the study and regulation of cell and tissue development, as components of cell culture media, and as diagnostic agents.
摘要翻译： 公开了多肽生长因子，其制备方法，编码它们的多核苷酸，针对它们的抗体以及使用它们的方法。 多肽包含与SEQ ID NO：2的残基46-163或SEQ ID NO：2的残基235-345至少90％相同的氨基酸区段。 还公开了多肽的多聚体。 多肽，多聚体蛋白和多核苷酸可用于细胞和组织发育的研究和调节，作为细胞培养基的组分和诊断剂。
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公开(公告)号：US08052976B2
公开(公告)日：2011-11-08
申请号：US12107571
申请日：2008-04-22
申请人： Zeren Gao , Charles E. Hart , Christopher S. Piddington , Paul O. Sheppard , Kimberty E. Shoemaker , Debra G. Gilbertson , James W. West
发明人： Zeren Gao , Charles E. Hart , Christopher S. Piddington , Paul O. Sheppard , Kimberty E. Shoemaker , Debra G. Gilbertson , James W. West
IPC分类号： A61K38/18
CPC分类号： C07K14/52 , A01K2217/05 , A61K38/1858 , C07K14/475 , C12N2799/022
摘要： Polypeptide growth factors, methods of making them, polynucleotides encoding them, antibodies to them, and methods of using them are disclosed. The polypeptides comprise an amino acid segment that is at least 90% identical to residues 46-163 of SEQ ID NO:2 or residues 235-345 of SEQ ID NO:2. Multimers of the polypeptides are also disclosed. The polypeptides, multimeric proteins, and polynucleotides can be used in the study and regulation of cell and tissue development, as components of cell culture media, and as diagnostic agents.
摘要翻译： 公开了多肽生长因子，其制备方法，编码它们的多核苷酸，针对它们的抗体以及使用它们的方法。 多肽包含与SEQ ID NO：2的残基46-163或SEQ ID NO：2的残基235-345至少90％相同的氨基酸区段。 还公开了多肽的多聚体。 多肽，多聚体蛋白和多核苷酸可用于细胞和组织发育的研究和调节，作为细胞培养基的组分和诊断剂。
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公开(公告)号：US20100167391A1
公开(公告)日：2010-07-01
申请号：US12107571
申请日：2008-04-22
申请人： Zeren Gao , Charles E. Hart , Christopher S. Piddington , Paul O. Sheppard , Kimberty E. Shoemaker , Debra G. Gilbertson , James W. West
发明人： Zeren Gao , Charles E. Hart , Christopher S. Piddington , Paul O. Sheppard , Kimberty E. Shoemaker , Debra G. Gilbertson , James W. West
IPC分类号： C12N5/071
CPC分类号： C07K14/52 , A01K2217/05 , A61K38/1858 , C07K14/475 , C12N2799/022
摘要： Polypeptide growth factors, methods of making them, polynucleotides encoding them, antibodies to them, and methods of using them are disclosed. The polypeptides comprise an amino acid segment that is at least 90% identical to residues 46-163 of SEQ ID NO:2 or residues 235-345 of SEQ ID NO:2. Multimers of the polypeptides are also disclosed. The polypeptides, multimeric proteins, and polynucleotides can be used in the study and regulation of cell and tissue development, as components of cell culture media, and as diagnostic agents.
摘要翻译： 公开了多肽生长因子，其制备方法，编码它们的多核苷酸，针对它们的抗体以及使用它们的方法。 多肽包含与SEQ ID NO：2的残基46-163或SEQ ID NO：2的残基235-345至少90％相同的氨基酸区段。 还公开了多肽的多聚体。 多肽，多聚体蛋白和多核苷酸可用于细胞和组织发育的研究和调节，作为细胞培养基的组分和诊断剂。
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公开(公告)号：US07658920B2
公开(公告)日：2010-02-09
申请号：US11552362
申请日：2006-10-24
申请人： Zeren Gao , Charles E. Hart , Christopher S. Piddington , Paul O. Sheppard , Kimberly E. Shoemaker
发明人： Zeren Gao , Charles E. Hart , Christopher S. Piddington , Paul O. Sheppard , Kimberly E. Shoemaker
CPC分类号： C07K14/52 , A01K2217/05 , A61K38/1858 , C07K14/475 , C12N2799/022
摘要： Polypeptide growth factor ZVEGF3, methods of making it, polynucleotides encoding it, antibodies that bind to it, and methods of using them are disclosed. The polypeptide comprises an amino acid segment that is at least 90% identical to residues 46-163 of SEQ ID NO:2 or residues 235-345 of SEQ ID NO:2. Multimers of the polypeptide are also disclosed. The polypeptide, multimeric proteins, and polynucleotides can be used in the study and regulation of cell and tissue development, as components of cell culture media, and as diagnostic agents. The antibodies may be used to inhibit cell growth.
摘要翻译： 公开了多肽生长因子ZVEGF3，其制备方法，编码它的多核苷酸，与其结合的抗体及其使用方法。 多肽包含与SEQ ID NO：2的残基46-163或SEQ ID NO：2的残基235-345至少90％相同的氨基酸区段。 还公开了多肽的多聚体。 多肽，多聚体蛋白质和多核苷酸可用于细胞和组织发育的研究和调节，作为细胞培养基的组分和诊断剂。 抗体可用于抑制细胞生长。
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8.发明授权Antibodies reactive to the c-terminal portion of growth factor homolog zvegf3 有权对生长因子同源物zvegf3的c-末端部分具有反应性的抗体公开(公告)号：US06887982B1
公开(公告)日：2005-05-03
申请号：US09541752
申请日：2000-03-31
申请人： Zeren Gao , Charles E. Hart , Christopher S. Piddington , Paul O. Sheppard , Kimberly E. Shoemaker
发明人： Zeren Gao , Charles E. Hart , Christopher S. Piddington , Paul O. Sheppard , Kimberly E. Shoemaker
IPC分类号： A61K38/00 , A61K38/18 , C07K14/475 , C07K14/52 , C07K16/18
CPC分类号： C07K14/52 , A01K2217/05 , A61K38/1858 , C07K14/475 , C12N2799/022
摘要： Polypeptide growth factors, methods of making them, polynucleotides encoding them, antibodies to them, and methods of using them are disclosed. The polypeptides comprise an amino acid segment that is at least 90% identical to residues 46-163 of SEQ ID NO:2 or residues 235-345 of SEQ ID NO:2. Multimers of the polypeptides are also disclosed. The polypeptides, multimeric proteins, and polynucleotides can be used in the study and regulation of cell and tissue development, as components of cell culture media, and as diagnostic agents.
摘要翻译： 公开了多肽生长因子，其制备方法，编码它们的多核苷酸，针对它们的抗体以及使用它们的方法。 多肽包含与SEQ ID NO：2的残基46-163或SEQ ID NO：2的残基235-345至少90％相同的氨基酸区段。 还公开了多肽的多聚体。 多肽，多聚体蛋白和多核苷酸可用于细胞和组织发育的研究和调节，作为细胞培养基的组分和诊断剂。
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公开(公告)号：US07691981B2
公开(公告)日：2010-04-06
申请号：US11552378
申请日：2006-10-24
申请人： Zeren Gao , Charles E. Hart , Christopher S. Piddington , Paul O. Sheppard , Kimberly E. Shoemaker
发明人： Zeren Gao , Charles E. Hart , Christopher S. Piddington , Paul O. Sheppard , Kimberly E. Shoemaker
IPC分类号： C12N15/00
CPC分类号： C07K14/52 , A01K2217/05 , A61K38/1858 , C07K14/475 , C12N2799/022
摘要： Polypeptide growth factors, methods of making them, polynucleotides encoding them, antibodies to them, and methods of using them are disclosed. The polypeptides comprise an amino acid segment that is at least 90% identical to residues 46-163 of SEQ ID NO:2 or residues 235-345 of SEQ ID NO:2. Multimers of the polypeptides are also disclosed. The polypeptides, multimeric proteins, and polynucleotides can be used in the study and regulation of cell and tissue development, as components of cell culture media, and as diagnostic agents.
摘要翻译： 公开了多肽生长因子，其制备方法，编码它们的多核苷酸，针对它们的抗体以及使用它们的方法。 多肽包含与SEQ ID NO：2的残基46-163或SEQ ID NO：2的残基235-345至少90％相同的氨基酸区段。 还公开了多肽的多聚体。 多肽，多聚体蛋白和多核苷酸可用于细胞和组织发育的研究和调节，作为细胞培养基的组分和诊断剂。
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公开(公告)号：US06962802B2
公开(公告)日：2005-11-08
申请号：US09876813
申请日：2001-06-06
IPC分类号： A61K38/00 , A61K38/18 , A61K38/19 , C07K14/52 , C12N15/09 , A61K38/24 , A61K38/27 , C07H21/04 , C12N15/00
CPC分类号： C04B38/06 , A61K38/177 , A61K38/18 , A61K38/1866 , A61K38/22 , C04B2111/00224 , C04B2111/00612 , C07K14/52 , C07K2319/00 , C12N2799/022 , C04B20/008 , C04B35/2641 , C04B35/50 , C04B35/64 , C04B38/0054 , C04B38/007 , C04B41/4578 , A61K2300/00
摘要： Polypeptide growth factors, methods of making them, polynucleotides encoding them, antibodies to them, and methods of using them are disclosed. The polypeptides comprise an amino acid segment that is at least 70% identical to residues 52-179 of SEQ ID NO:2 or residues 258-370 of SEQ ID NO:2. Multimers of the polypeptides are also disclosed. The polypeptides, multimeric proteins, and polynucleotides can be used in the study and regulation of cell and tissue development, as components of cell culture media, and as diagnostic agents.
摘要翻译： 公开了多肽生长因子，其制备方法，编码它们的多核苷酸，针对它们的抗体以及使用它们的方法。 多肽包含与SEQ ID NO：2的残基52-179或SEQ ID NO：2的残基258-370至少70％相同的氨基酸区段。 还公开了多肽的多聚体。 多肽，多聚体蛋白和多核苷酸可用于细胞和组织发育的研究和调节，作为细胞培养基的组分和诊断剂。
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